KEGG   REACTION: R06459
Entry
R06459                      Reaction                               

Name
(2S)-methylmalonyl-CoA:malonyl-CoA malonyltransferase (narbonolide forming)
Definition
6 (S)-Methylmalonyl-CoA + Malonyl-CoA + 5 NADPH + 5 H+ <=> Narbonolide + 7 CoA + 7 CO2 + 5 NADP+ + 2 H2O
Equation
6 C00683 + C00083 + 5 C00005 + 5 C00080 <=> C11997 + 7 C00010 + 7 C00011 + 5 C00006 + 2 C00001
Comment
type I polyketide synthase, PikA1-4
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C00683
RC02828  C00683_C11997
RC02829  C00683_C11997
RC02830  C00683_C11997
RC02910  C00683_C11997
RC02911  C00083_C11997
RC02915  C00683_C11997
RC03330  C00683_C11997
Enzyme
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00776  Pikromycin/methymycin biosynthesis, methylmalonyl-CoA + malonyl-CoA => narbonolide/10-deoxymethynolide => pikromycin/methymycin
Orthology
K16000  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16001  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16002  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16003  narbonolide synthase [EC:2.3.1.240]
Other DBs
RHEA: 42847

KEGG   RCLASS: RC02911
Entry
RC02911                     RClass                                 

Definition
C1b-C2x:C6a+*-*+C2x:C5a-C5x
C5a-C5x:S2a+*-*+C1y:C1b+O5a-C2x+O5x
Reactant pair
Related class
Reaction
Enzyme
2.3.1.239       2.3.1.240
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K15988  tylactone synthase 1
K16000  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16001  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16002  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16003  narbonolide synthase [EC:2.3.1.240]
K24555  tylactone synthase 2
K24556  tylactone synthase 3
K24557  tylactone synthase 4
K24558  tylactone synthase 5

KEGG   RCLASS: RC02910
Entry
RC02910                     RClass                                 

Definition
C1b-C1c:*-C6a:C1a+C1y-C1a+C5a
C1y-C5a:C1y+*-*+S2a:C1b+O7x-C1c+O5a
O7x-O5a:C7x-*:C1y-C5a
Reactant pair
Related class
Reaction
Enzyme
2.3.1.239       2.3.1.240
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K15988  tylactone synthase 1
K16000  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16001  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16002  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16003  narbonolide synthase [EC:2.3.1.240]
K24555  tylactone synthase 2
K24556  tylactone synthase 3
K24557  tylactone synthase 4
K24558  tylactone synthase 5

KEGG   RCLASS: RC03330
Entry
RC03330                     RClass                                 

Definition
C1c-C1y:C6a+*-*+C5x:C1a+C5a-C1a+C7x
C5a-C7x:S2a+*-*+O7x:C1c+O5a-C1y+O6a
Reactant pair
Related class
Reaction
Enzyme
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K16000  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16001  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16002  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16003  narbonolide synthase [EC:2.3.1.240]

KEGG   RCLASS: RC02915
Entry
RC02915                     RClass                                 

Definition
C1c-C1y:C6a+*-*+C1y:C1a+C5a-C1a+C2x
C5a-C2x:O5a+S2a+*-*+*+C2x:C1c-C1y
Reactant pair
Related class
Reaction
Enzyme
2.3.1.239       2.3.1.240
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K14371  avermectin polyketide synthase AveA1
K16000  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16001  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16002  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16003  narbonolide synthase [EC:2.3.1.240]
K24567  avermectin polyketide synthase AveA2
K24568  avermectin polyketide synthase AveA3
K24569  avermectin polyketide synthase AveA4

KEGG   RCLASS: RC02829
Entry
RC02829                     RClass                                 

Definition
C1c-C1y:C6a+*-*+C5x:C1a+C5a-C1a+C1x
C5a-C1x:O5a+S2a+*-*+*+C1y:C1c-C1y
Reactant pair
Related class
Reaction
Enzyme
2.3.1.94        2.3.1.239       2.3.1.240
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K10817  6-deoxyerythronolide-B synthase EryAI [EC:2.3.1.94]
K15988  tylactone synthase 1
K16000  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16001  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16002  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16003  narbonolide synthase [EC:2.3.1.240]
K16007  8,8a-deoxyoleandolide synthase 1
K24555  tylactone synthase 2
K24556  tylactone synthase 3
K24557  tylactone synthase 4
K24558  tylactone synthase 5
K24563  6-deoxyerythronolide B synthase EryAII [EC:2.3.1.94]
K24564  6-deoxyerythronolide B synthase EryAIII [EC:2.3.1.94]
K24565  8,8a-deoxyoleandolide synthase 2
K24566  8,8a-deoxyoleandolide synthase 3

KEGG   RCLASS: RC02830
Entry
RC02830                     RClass                                 

Definition
C1c-C1y:C6a+*-*+C1x:C1a+C5a-C1a+C1y
C5a-C1y:S2a+*-*+C1y:C1c+O5a-C1y+O1a
Reactant pair
Related class
Reaction
Enzyme
2.3.1.94        2.3.1.239       2.3.1.240
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K10817  6-deoxyerythronolide-B synthase EryAI [EC:2.3.1.94]
K16000  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16001  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16002  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16003  narbonolide synthase [EC:2.3.1.240]
K16007  8,8a-deoxyoleandolide synthase 1
K24563  6-deoxyerythronolide B synthase EryAII [EC:2.3.1.94]
K24564  6-deoxyerythronolide B synthase EryAIII [EC:2.3.1.94]
K24565  8,8a-deoxyoleandolide synthase 2
K24566  8,8a-deoxyoleandolide synthase 3

KEGG   RCLASS: RC02828
Entry
RC02828                     RClass                                 

Definition
C1c-C1y:C6a+*-*+C1y:C1a+C5a-C1a+C5x
C5a-C5x:S2a+*-*+C1y:C1c+O5a-C1y+O5x
Reactant pair
Related class
Reaction
Enzyme
2.3.1.94        2.3.1.240
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K10817  6-deoxyerythronolide-B synthase EryAI [EC:2.3.1.94]
K16000  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16001  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16002  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16003  narbonolide synthase [EC:2.3.1.240]
K16007  8,8a-deoxyoleandolide synthase 1
K24563  6-deoxyerythronolide B synthase EryAII [EC:2.3.1.94]
K24564  6-deoxyerythronolide B synthase EryAIII [EC:2.3.1.94]
K24565  8,8a-deoxyoleandolide synthase 2
K24566  8,8a-deoxyoleandolide synthase 3

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