KEGG   REACTION: R06481
Entry
R06481                      Reaction                               

Definition
2-Methylbutanoyl-CoA + 5 Methylmalonyl-CoA + 7 Malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1a'' aglycone + 12 CO2 + 13 CoA + 6 H2O + 9 NADP+
Equation
C01033 + 5 C02557 + 7 C00083 + 9 C00005 + 9 C00080 <=> C11977 + 12 C00011 + 13 C00010 + 6 C00001 + 9 C00006
Comment
type I polyketide synthase, AveA1-4
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C01033  C00010_C02557
RC02913  C01033_C11977
RC02915  C02557_C11977
RC02920  C02557_C11977
RC02921  C02557_C11977
RC02922  C02557_C11977
RC02924  C00083_C11977
RC02925  C00083_C11977
RC02926  C00083_C11977
RC02927  C00083_C11977
RC02928  C00083_C11977
RC02929  C00083_C11977
RC02930  C00083_C11977
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Orthology
K14371  avermectin polyketide synthase AveA1
K24567  avermectin polyketide synthase AveA2
K24568  avermectin polyketide synthase AveA3
K24569  avermectin polyketide synthase AveA4

KEGG   RCLASS: RC02913
Entry
RC02913                     RClass                                 

Definition
C1y-C5a:C1y+*-*+S2a:C1c+O2x-C1c+O5a
O2x-O5a:C1z-*:C1y-C5a
Reactant pair
Related class
Reaction
Pathway
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K14371  avermectin polyketide synthase AveA1
K24567  avermectin polyketide synthase AveA2
K24568  avermectin polyketide synthase AveA3
K24569  avermectin polyketide synthase AveA4

KEGG   RCLASS: RC02915
Entry
RC02915                     RClass                                 

Definition
C1c-C1y:C6a+*-*+C1y:C1a+C5a-C1a+C2x
C5a-C2x:O5a+S2a+*-*+*+C2x:C1c-C1y
Reactant pair
Related class
Reaction
Enzyme
2.3.1.239       2.3.1.240
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K14371  avermectin polyketide synthase AveA1
K16000  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16001  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16002  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16003  narbonolide synthase [EC:2.3.1.240]
K24567  avermectin polyketide synthase AveA2
K24568  avermectin polyketide synthase AveA3
K24569  avermectin polyketide synthase AveA4

KEGG   RCLASS: RC02920
Entry
RC02920                     RClass                                 

Definition
C1c-C2y:C6a+*-*+C2x:C1a+C5a-C1a+C1y
C5a-C1y:S2a+*-*+C1y:C1c+O5a-C2y+O1a
Reactant pair
Related class
Reaction
Pathway
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K14371  avermectin polyketide synthase AveA1
K24567  avermectin polyketide synthase AveA2
K24568  avermectin polyketide synthase AveA3
K24569  avermectin polyketide synthase AveA4

KEGG   RCLASS: RC02921
Entry
RC02921                     RClass                                 

Definition
C1c-C2y:C6a+*-*+C2x:C1a+C5a-C1a+C1z
C5a-C1z:S2a+*+*-*+C1x+C1y:C1c+O5a-C2y+O1a
Reactant pair
Related class
Reaction
Pathway
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K14371  avermectin polyketide synthase AveA1
K24567  avermectin polyketide synthase AveA2
K24568  avermectin polyketide synthase AveA3
K24569  avermectin polyketide synthase AveA4

KEGG   RCLASS: RC02922
Entry
RC02922                     RClass                                 

Definition
C1c-C2y:C6a+*-*+C5x:C1a+C5a-C1a+C2x
C5a-C2x:O5a+S2a+*-*+*+C1y:C1c-C2y
Reactant pair
Related class
Reaction
Pathway
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K14371  avermectin polyketide synthase AveA1
K24567  avermectin polyketide synthase AveA2
K24568  avermectin polyketide synthase AveA3
K24569  avermectin polyketide synthase AveA4

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