KEGG   REACTION: R07961
Entry
R07961                      Reaction                               

Name
theobromine:oxygen oxidoreductase (N3-demethylating)
Definition
Theobromine + NADH + H+ + Oxygen <=> 7-Methylxanthine + NAD+ + Formaldehyde + H2O
Equation
Reaction class
RC00001  C00003_C00004
RC00334  C07480_C16353
RC01797  C00067_C07480
Enzyme
Pathway
rn00232  Caffeine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Module
M00915  Caffeine degradation, caffeine => xanthine
Orthology
K21723  methylxanthine N3-demethylase [EC:1.14.13.179]
Other DBs
RHEA: 30322

KEGG   REACTION: R07962
Entry
R07962                      Reaction                               

Name
theobromine:oxygen oxidoreductase (N3-demethylating)
Definition
Theobromine + NADPH + H+ + Oxygen <=> 7-Methylxanthine + NADP+ + Formaldehyde + H2O
Equation
Reaction class
RC00001  C00005_C00006
RC00334  C07480_C16353
RC01797  C00067_C07480
Enzyme
Pathway
rn00232  Caffeine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Module
M00915  Caffeine degradation, caffeine => xanthine
Orthology
K21723  methylxanthine N3-demethylase [EC:1.14.13.179]
Other DBs
RHEA: 36290

KEGG   REACTION: R07919
Entry
R07919                      Reaction                               

Name
S-adenosyl-L-methionine:7-methylxanthine N3-methyltransferase
Definition
S-Adenosyl-L-methionine + 7-Methylxanthine <=> S-Adenosyl-L-homocysteine + Theobromine
Equation
Reaction class
RC00003  C00019_C00021
RC00334  C07480_C16353
Enzyme
2.1.1.159       2.1.1.160
Pathway
rn00232  Caffeine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Orthology
K12730  theobromine synthase [EC:2.1.1.159]
K12731  caffeine synthase [EC:2.1.1.160]
Other DBs
RHEA: 24607

KEGG   RCLASS: RC00334
Entry
RC00334                     RClass                                 

Definition
N4x-N4y:*-C1a:C8y+C8y-C8y+C8y
Reactant pair
Related class
Reaction
Enzyme
1.14.13.178     1.14.13.179     1.14.14.1       2.1.1.159       
2.1.1.160       2.1.1.228       2.1.1.282       2.1.1.349
Pathway
rn00232  Caffeine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Orthology
K00554  tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
K07409  cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
K12730  theobromine synthase [EC:2.1.1.159]
K12731  caffeine synthase [EC:2.1.1.160]
K15429  tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
K20331  toxoflavin synthase [EC:2.1.1.349]
K21722  methylxanthine N1-demethylase [EC:1.14.13.178]
K21723  methylxanthine N3-demethylase [EC:1.14.13.179]

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