KEGG   REACTION: R07975
Entry
R07975                      Reaction                               

Name
theophylline:oxygen oxidoreductase (N3-demethylating)
Definition
Theophylline + NADH + H+ + Oxygen <=> 1-Methylxanthine + NAD+ + Formaldehyde + H2O
Equation
Reaction class
RC00001  C00003_C00004
RC00334  C07130_C16358
RC01797  C00067_C07130
Enzyme
Pathway
rn00232  Caffeine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Orthology
K21723  methylxanthine N3-demethylase [EC:1.14.13.179]

KEGG   REACTION: R07976
Entry
R07976                      Reaction                               

Name
theophylline:oxygen oxidoreductase (N3-demethylating)
Definition
Theophylline + NADPH + H+ + Oxygen <=> 1-Methylxanthine + NADP+ + Formaldehyde + H2O
Equation
Reaction class
RC00001  C00005_C00006
RC00334  C07130_C16358
RC01797  C00067_C07130
Enzyme
Pathway
rn00232  Caffeine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Orthology
K21723  methylxanthine N3-demethylase [EC:1.14.13.179]

KEGG   RCLASS: RC00334
Entry
RC00334                     RClass                                 

Definition
N4x-N4y:*-C1a:C8y+C8y-C8y+C8y
Reactant pair
Related class
Reaction
Enzyme
1.14.13.178     1.14.13.179     1.14.14.1       2.1.1.159       
2.1.1.160       2.1.1.228       2.1.1.282       2.1.1.349
Pathway
rn00232  Caffeine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Orthology
K00554  tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
K07409  cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
K12730  theobromine synthase [EC:2.1.1.159]
K12731  caffeine synthase [EC:2.1.1.160]
K15429  tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
K20331  toxoflavin synthase [EC:2.1.1.349]
K21722  methylxanthine N1-demethylase [EC:1.14.13.178]
K21723  methylxanthine N3-demethylase [EC:1.14.13.179]

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