KEGG   REACTION: R08392
Entry
R08392                      Reaction                               

Definition
Retinoate + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> all-trans-4-Hydroxyretinoic acid + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
Comment
CYP1A1/2, CYP2A6, CYP2B6, CYP2C8/9/18, CYP3A4/5/7, CYP26, CYP2S1
Reaction class
RC00723  C00777_C16677
Enzyme
1.14.14.1       1.14.14.-
Pathway
rn00830  Retinol metabolism
rn01100  Metabolic pathways
Orthology
K07408  cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]
K07409  cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
K07411  cytochrome P450 family 2 subfamily A [EC:1.14.14.1]
K07412  cytochrome P450 family 2 subfamily B [EC:1.14.14.1]
K07413  cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
K07420  cytochrome P450 family 2 subfamily S1 [EC:1.14.14.1]
K07423  cytochrome P450 family 2 subfamily W1 [EC:1.14.14.-]
K07424  cytochrome P450 family 3 subfamily A [EC:1.14.14.1]
K07437  cytochrome P450 family 26 subfamily A [EC:1.14.14.-]
K12664  cytochrome P450 family 26 subfamily B [EC:1.14.14.-]
K12665  cytochrome P450 family 26 subfamily C [EC:1.14.14.-]
K17683  cytochrome P450 family 2 subfamily A6 [EC:1.14.14.-]
K17689  cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
K17690  cytochrome P450 family 3 subfamily A5 [EC:1.14.14.1]
K17691  cytochrome P450 family 3 subfamily A7 [EC:1.14.14.1]
K17709  cytochrome P450 family 2 subfamily B6 [EC:1.14.14.-]
K17718  cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]
K17719  cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
K17720  cytochrome P450 family 2 subfamily C18 [EC:1.14.14.1]

KEGG   RCLASS: RC00723
Entry
RC00723                     RClass                                 

Definition
C1x-C1y:*-O1a:C1x+C2y-C1x+C2y
Reactant pair
Related class
Reaction
Enzyme
1.14.13.106     1.14.13.153     1.14.13.-       1.14.14.1       
1.14.14.51      1.14.14.53      1.14.14.105     1.14.14.106     
1.14.14.123     1.14.14.159     1.14.14.-       1.14.15.18      
1.14.15.22
Pathway
rn00100  Steroid biosynthesis
rn00830  Retinol metabolism
rn00902  Monoterpenoid biosynthesis
rn00903  Limonene and pinene degradation
rn00904  Diterpenoid biosynthesis
rn00906  Carotenoid biosynthesis
rn00909  Sesquiterpenoid and triterpenoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K07381  (S)-limonene 6-monooxygenase [EC:1.14.14.51]
K07408  cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]
K07409  cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
K07411  cytochrome P450 family 2 subfamily A [EC:1.14.14.1]
K07412  cytochrome P450 family 2 subfamily B [EC:1.14.14.1]
K07413  cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
K07420  cytochrome P450 family 2 subfamily S1 [EC:1.14.14.1]
K07423  cytochrome P450 family 2 subfamily W1 [EC:1.14.14.-]
K07424  cytochrome P450 family 3 subfamily A [EC:1.14.14.1]
K07437  cytochrome P450 family 26 subfamily A [EC:1.14.14.-]
K07438  calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.15.18]
K12645  epi-isozizaene 5-monooxygenase / beta-farnesene synthase [EC:1.14.13.106 4.2.3.47]
K12664  cytochrome P450 family 26 subfamily B [EC:1.14.14.-]
K12665  cytochrome P450 family 26 subfamily C [EC:1.14.14.-]
K12922  taxane 13alpha-hydroxylase [EC:1.14.14.106]
K12924  taxane 10beta-hydroxylase [EC:1.14.14.105]
K14732  limonene hydroxylase [EC:1.14.14.51 1.14.14.52 1.1.1.243 1.1.1.144]
K16084  ent-cassa-12,15-diene 11-hydroxylase / oryzalexin D synthase [EC:1.14.14.112 1.14.14.123]
K17683  cytochrome P450 family 2 subfamily A6 [EC:1.14.14.-]
K17689  cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
K17690  cytochrome P450 family 3 subfamily A5 [EC:1.14.14.1]
K17691  cytochrome P450 family 3 subfamily A7 [EC:1.14.14.1]
K17709  cytochrome P450 family 2 subfamily B6 [EC:1.14.14.-]
K17718  cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]
K17719  cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
K17720  cytochrome P450 family 2 subfamily C18 [EC:1.14.14.1]
K21146  vitamin D 1,25-hydroxylase [EC:1.14.15.22]

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