KEGG   REACTION: R08549
Entry
R08549                      Reaction                               

Name
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating);
2-Oxoglutarate dehydrogenase complex
Definition
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
Equation
Comment
multienzyme system
multi-step reaction (see R01700+R02570+R07618)
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00091
RC02833  C00026_C00091
Enzyme
Pathway
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Orthology
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K00382  dihydrolipoamide dehydrogenase [EC:1.8.1.4]
K00658  2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
Other DBs
RHEA: 27789

KEGG   REACTION: R01197
Entry
R01197                      Reaction                               

Name
2-oxoglutarate:ferredoxin oxidoreductase (decarboxylating)
Definition
2 Reduced ferredoxin + Succinyl-CoA + CO2 + 2 H+ <=> 2 Oxidized ferredoxin + 2-Oxoglutarate + CoA
Equation
Reaction class
RC00004  C00010_C00091
RC02833  C00026_C00091
Enzyme
1.2.7.3         1.2.7.11
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
M00620  Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate
Orthology
K00174  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]
K00175  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]
K00176  2-oxoglutarate ferredoxin oxidoreductase subunit delta [EC:1.2.7.3]
K00177  2-oxoglutarate ferredoxin oxidoreductase subunit gamma [EC:1.2.7.3]
Other DBs
RHEA: 17300

KEGG   RCLASS: RC02833
Entry
RC02833                     RClass                                 

Definition
C5a-C5a:C6a+*-*+S2a:C1b+O5a-C1b+O5a
Reactant pair
Related class
Reaction
Enzyme
1.2.1.105       1.2.4.2         1.2.4.4         1.2.7.1         
1.2.7.3         1.2.7.7         1.2.7.11        1.8.1.4         
2.3.1.54        2.3.1.61
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00280  Valine, leucine and isoleucine degradation
rn00310  Lysine degradation
rn00380  Tryptophan metabolism
rn00640  Propanoate metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
RModule
RM903  Oxidative decarboxylation of 2-oxoacid to form its CoA derivative
Orthology
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K00166  2-oxoisovalerate dehydrogenase E1 component alpha subunit [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component beta subunit [EC:1.2.4.4]
K00169  pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]
K00170  pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1]
K00171  pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1]
K00172  pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]
K00174  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]
K00175  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]
K00176  2-oxoglutarate ferredoxin oxidoreductase subunit delta [EC:1.2.7.3]
K00177  2-oxoglutarate ferredoxin oxidoreductase subunit gamma [EC:1.2.7.3]
K00186  2-oxoisovalerate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.7]
K00187  2-oxoisovalerate ferredoxin oxidoreductase beta subunit [EC:1.2.7.7]
K00188  2-oxoisovalerate ferredoxin oxidoreductase delta subunit [EC:1.2.7.7]
K00189  2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1]
K00382  dihydrolipoamide dehydrogenase [EC:1.8.1.4]
K00656  formate C-acetyltransferase [EC:2.3.1.54]
K00658  2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]
K15791  probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 [EC:1.2.4.2]

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