KEGG   REACTION: R09314
Entry
R09314                      Reaction                               

Definition
6-Deoxydihydrokalafungin + Reduced FMN + Oxygen <=> Dihydrokalafungin + FMN + H2O
Equation
Comment
C6 oxygenation, FMN-dependent monooxygenase
Reaction class
RC00126  C00061_C01847
RC01675  C12435_C12436
Enzyme
1.14.14.-
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00779  Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
Orthology
K14630  two-component flavin-dependent monooxygenase [EC:1.14.14.-]

KEGG   REACTION: R05705
Entry
R05705                      Reaction                               

Name
FMNH2:NAD+ oxidoreductase
Definition
Reduced FMN + NAD+ <=> FMN + NADH + H+
Equation
Comment
see R05706 (NADPH)
Reaction class
RC00001  C00003_C00004
RC00126  C00061_C01847
Enzyme
1.5.1.36        1.5.1.39        1.5.1.41        1.5.1.42        
1.5.1.-
Pathway
rn00740  Riboflavin metabolism
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01240  Biosynthesis of cofactors
Module
M00779  Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
Orthology
K00484  flavin reductase (NADH) [EC:1.5.1.36]
K05368  NAD(P)H-flavin reductase [EC:1.5.1.41]
K13562  NAD(P)H:FMN oxidoreductase [EC:1.5.1.-]
K14631  flavin reductase ActVB [EC:1.5.1.-]
K19286  FMN reductase [NAD(P)H] [EC:1.5.1.39]
K20146  nitrilotriacetate monooxygenase reductase component [EC:1.5.1.42]
K22393  flavin reductase (NADH) subunit 1 [EC:1.5.1.36]
K22394  flavin reductase (NADH) subunit 2 [EC:1.5.1.36]
K23462  flavin-dependent trigonelline monooxygenase, reductase component [EC:1.5.1.36]
K23470  4-hydroxyphenylacetate 3-hydroxylase, reductase component [EC:1.5.1.36]
Other DBs
RHEA: 21623

KEGG   REACTION: R06696
Entry
R06696                      Reaction                               

Definition
6-Deoxydihydrokalafungin + Oxygen <=> Dihydrokalafungin + H2O
Equation
Comment
cofactor-independent monooxygenase, actVA-orf6
Reaction class
RC01675  C12435_C12436
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00779  Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
Orthology
K14632  C-6 monooxygenase

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