KEGG   REACTION: R10685
Entry
R10685                      Reaction                               

Name
NAD+:glycine ADP-D-ribosyltransferase (dehydroalanine-producing)
Definition
NAD+ + Glycine + [Protein]-L-cysteine <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + Nicotinamide + [Protein]-dehydroalanine + 3 H2O
Equation
Comment
thiamine thiazole synthase
multi-step reaction
Sulfur donor is enzyme itself (one cystein residue looses H2S to form dehydroalanie residue)
Reaction class
RC00033  C00003_C00153
RC03253  C00003_C20784
RC03254  C00037_C20784
Enzyme
Pathway
rn00730  Thiamine metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00897  Thiamine biosynthesis, plants, AIR (+ NAD+) => TMP/thiamine/TPP
M00898  Thiamine biosynthesis, pyridoxal-5P => TMP/thiamine/TPP
Orthology
K03146  cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60]
Other DBs
RHEA: 55711

KEGG   REACTION: R12026
Entry
R12026                      Reaction                               

Name
NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding)
Definition
NAD+ + Glycine + Hydrogen sulfide <=> Nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 3 H2O
Equation
Reaction class
RC00033  C00003_C00153
RC03253  C00003_C20784
RC03254  C00037_C20784
Enzyme
Pathway
rn00730  Thiamine metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00896  Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP
Orthology
K22699  sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59]
Other DBs
RHEA: 55707

KEGG   RCLASS: RC03253
Entry
RC03253                     RClass                                 

Definition
C1a-C1y:*+*-N5y+O2x:C8y-C1y
C1b-C1y:*-O2x:C1b+C8y-C1b+C1y
C8y-C1y:N5x+*-*+O1a:C1a+C8y-C1y+C1y
C8y-C1y:S2x+*-*+O1a:C1b+C8y-C1y+C1y
Reactant pair
Related class
Reaction
Enzyme
2.4.2.59        2.4.2.60
Pathway
rn00730  Thiamine metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Orthology
K03146  cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60]
K22699  sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59]

KEGG   RCLASS: RC03254
Entry
RC03254                     RClass                                 

Definition
C1b-C8y:*-S2x:C6a+N1a-C6a+N5x
N1a-N5x:*-C8y:C1b-C8y
Reactant pair
Related class
Reaction
Enzyme
2.4.2.59        2.4.2.60
Pathway
rn00730  Thiamine metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Orthology
K03146  cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60]
K22699  sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59]

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