KEGG   REACTION: R11268
Entry
R11268                      Reaction                               

Name
kanamycin-C:oxygen 6'-oxidoreductase
Definition
Kanamycin C + Oxygen <=> 6'-Oxokanamycin C + Hydrogen peroxide
Equation
Reaction class
RC00450  C01823_C21252
Enzyme
1.1.3.-
Pathway
rn00524  Neomycin, kanamycin and gentamicin biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K20566  paromamine 6'-oxidase / 2'-deamino-2'-hydroxyparomamine 6'-oxidase [EC:1.1.3.43 1.1.3.-]
Reference
1  [PMID:21983602]
  Authors
Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ
  Title
Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.
  Journal
Nat Chem Biol 7:843-52 (2011)
DOI:10.1038/nchembio.671

KEGG   RCLASS: RC00450
Entry
RC00450                     RClass                                 

Definition
C1b-C4a:*-*:C1y+O1a-C1y+O4a
Reactant pair
Related class
Reaction
Enzyme
1.1.1.273       1.1.1.317       1.1.3.9         1.1.3.28        
1.1.3.39        1.1.3.43        1.1.3.44        1.1.3.-         
1.14.18.11
Pathway
rn00524  Neomycin, kanamycin and gentamicin biosynthesis
rn00901  Indole alkaloid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K13552  paromamine 6'-oxidase [EC:1.1.3.43]
K20565  paromamine 6'-oxidase / 6'''-hydroxyneomycin C oxidase [EC:1.1.3.43 1.1.3.44]
K20566  paromamine 6'-oxidase / 2'-deamino-2'-hydroxyparomamine 6'-oxidase [EC:1.1.3.43 1.1.3.-]
K20577  paromamine/lividamine 6'-oxidase [EC:1.1.3.43 1.1.3.-]
K20584  6'''-hydroxyparomomycin oxidase [EC:1.1.3.-]
K20595  gentamicin-X2/G418 6'-oxidase

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