KEGG   Addendum: AAK73513
Entry
AAK73513          CDS       T10000                                 
Symbol
amphB
Name
(KEGG) polyene macrolide polyketide synthase, A-type KR domains
  KO
K16383  polyene macrolide polyketide synthase, A-type KR domains
Taxonomy
TAX:40318
  Lineage
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces
Organism
Streptomyces nodosus
SSDB
Motif
Pfam: Acyl_transf_1 ketoacyl-synt KR Ketoacyl-synt_C adh_short PKS_DE PP-binding KAsynt_C_assoc adh_short_C2 Epimerase Thiolase_N Polysacc_synt_2 Docking GDP_Man_Dehyd ACP_syn_III RmlD_sub_bind NmrA F420_oxidored
Other DBs
NCBI-ProteinID: AAK73513
GB: AF357202
UniProt: Q93NW7
Structure
AA seq 3190 aa
MPEPQQNQQEKVVDYLRRVTNDLRRARRRIGELESRDNEPVAIVGMSCRLPGGVSSPESL
WELVESGGDAISGFPADRGWDIEALTGKGEGSSSTHEGGFLYEATDFDAGFFGISPREAT
AMDPQQRLLLEVSWEALERAGIAPTSLRSSATGVFVGSYHWGAPSADTATELHGHALTGT
AASVLSGRLSYVYGLEGPAVTVDTACSSSLVALHMAAQSLRNGESSLALVGGVTILAEPS
VFVEFSAQGGLAQDGRCKAFSDSADGTGWSEGAAVLVVERLSDARRAGHRVLAVVRGSAV
NQDGASNGLTAPNGPSQQRVIRQALANAGLRPGDVDAVEAHGTGTPLGDPIEAQALIATY
GSDRDPQQPLLLGSVKSNIGHTQSAAGVAGLVKMVMAMHNGTLPRTLHLTEPSTHVDWSL
GAVRLLTEETAWPETGRVRRAAVSSFGISGTNAHAVLEQAPVPAEDAEDAGTEDAPQQPA
TVPGALPWLLSAHSGQALCDQAAALVTRLDADPEPRPQDIGQGLLTSRALLERRAVVVGT
GRDELLTGSRALAEGQSWNGLAEGTADVDGRTVFVFPGQGSQWVGMGARLLDESPVFAER
IAECAAALAEFTDWDLLDVLRGAEGAPTLERVDVVQPASFAVMVSLAAVWRAQGVEPDAV
VGHSQGEIAAAVVSGALSLRDGARVVALRSQAIGRTLAGRGGMMSVALPVADVEARLEAF
GGRVSVAAENGPRSCVVSGEPGALDELSELLTAEGVRVRRVPVDYASHSHHVEDLHDEIL
QLLAEVAPKASEVPLFSTVTGDWLDTTVMDAGYWFRSLRGRVLFADAIRGLLDTEHRAFI
EVSSHPVLAMSVQDMIDDAGVVGVASGTLRRDNGGLDRFLLSAAQVFVRGVQVDWAPLFE
GTGATRVDLPTYAFQHERYWNDRAVVDRSASAPMDAEFWAAVEQADVSALTEALGTDEES
VAAILPGLASWRRTRGERSTVDSWRYRVVWEPLAQIPRATLDGTWLLVSAGGVDDDVAEV
LEAGGAEVRRLVLDETCTDPAVLREHLTDTDGLTGIVSVLADAEEGCVRHPGLTLGLALS
VSLAQALGEADVTAPLWFLTCGAFSTGPSDTVTRPLQSQIAGLGWTVAVEHPHRWGGGVD
LPEALDARAAQRLVAALAGALGDDDQLAVRPAGVLARRIVRASGDTRRKARSWKPRGTTL
VTGGSGTLAPGLARHLAAQGAEHLVLLSRRGADAPGAAELAAELQAAGTEVRFAACDITD
PDAVAALLADLKAEGRTVRTVVHTAAVIELAALADTTVDAFADVVHAKVTGARILDELLD
DEELDDFVLYSSTAGMWGSGVHAAYVAGNAYLSALAEQRRARGARATSIHWGKWPDDLER
ELADPHQIRRSGLEYLDPELAMTALTRVMEDDETVIGLMDIDWGTYHDVFTAGRPSHLFD
RIPEVARLLADRAAPAATAVATSGLAARLQGVSAAEQDRIVLSVVREETAAVLGHASAET
VPERRAFRDIGFDSVTAVDLRNRLVAATGLTLPSTMVFDHPNAVALATFLKATALGTTGT
AGDRPTAAVTAGADDDLIVIVGMSCRFPGGANTPEELLRLALDGADVISEFPADRGWDAH
GLYDPDPDRQGRTYSVHGGFLHEAAGFDAGFFGISPREALAMDPQQRLLLETSWEVLERA
GIDPESLHSTATGAFFGASYQDYSSSVQNGTEGAEVHMMTGTAASVLSGRISYLLGLEGP
AVTVDTACSSSLVAMHLACQSLRSGESSLALAGGAAVMATPHAFIGFSRQRALAENGRCK
PFAEGADGMTLAEGVGVVLLEKLSDARRNGHRVLAVVRGSALNQDGASNGLTAPNGLSQQ
RVIRQALANAGLGTADIDVVEAHGTGTKLGDPIEAGALLATYGQGRDGGQPLLLGSVKSN
IGHTQAAAGVAGVIKMVMAMHAGELPGTLHIDEPSSHVDWTSGAVTLLRERTEWPAVGDR
PRRAGISSFGISGTNAHLLLEQAPPAEEPAEEPAGDIEGAPLVPWLLSARSAQALREQAS
RLLTATTGTDVTVEPARVGHALATTRTAFDHRAVVLGSRPEDFTRGLEAVVSSASAPGVV
TGTAGPDSTGPVFVYPGQGSQWWGMGRELLAGSEVFRTAVDDCAAALAPYTDWSLHEVLA
GEGDPELLERVDVVQPALFSMMVALTALWRSHGVEPAAVVGHSQGEIAAAHVAGALSLED
AALVVALRSQALPQLSGLGGMMSVSAPAARVTELLQPWGEALSIAAVNGPSSVIVSGDAD
ALDELLETCREQNVRARKVSVDYASHGRHVEAVRDELARVLAPVSPRTPEVPFYSTVTGA
RLDEAAFDGTYWYTNLRQTVLMEDATRALIASGHRVFVEISPHPVLAAPIQETQESVQEE
LTETGAVLGTLRRDDGDRRRFLTSLAEAHTHGIAVDWTTAFDRPAYAAVDLPTYPFQRQD
FWPEPKTAAPAGTADASDAAFWELVQNQDLDALAGELGIPADDGAARLGDVLPALSAWRT
RSLTRSRADALRYHIEWNRVAEPGTARPAGRLLAVISPDHAGAPWVTAVLDALGPDTVRF
EAKGTDRAAWAAQLAQLREDEGEFHAVVSLLAAAEALHTDHGSVPLGLAQTLLLAQALGD
AGLTAPLWCLTRGGVAAGRGDVLSSPVQGALWGLGRVIGLEHPDRWGGLIDLPETVDTRA
AARLTGLLADAGGEDQLAIRGSGVLARRLAHAAPAVPGSGKRPPVHGSVLVTGGTGGIGG
RVARRLAEQGAAHLVLTSRRGADAPGAAELRAELEQLGVRVTIAACDAADREALAALLAE
LPEDAPLTAVFHSAGVAHDDAPVADLTLGQLDALMRAKLTAARHLHELTADLDLDAFVLF
SSGAAVWGSGGQPGYAAANAYLDALAEHRRSLGLTASSVAWGTWGEVGMATDPEVHDRLV
RQGVLAMEPEHALGALDQMLENDDTAAAITLMDWEMFAPAFTANRPSALLSTVPEAVSAL
SDEGPADGGADAAVPPLRARLDGLPTAERARALVEAVRAEASATLGHDSPDAVPASRAFR
DVGFDSVTAVELRNRLRAALGLPLPAALVFDYPTPTALAQHIGSLLYGTAPDEADTGRAD
DPDARIREALATVPIGRLRKAGLLDMVLKLAESDDTEDSATATDDAADALDLDDMDAEAL
LRLAAENSAN
Reference
PMID:11451671
  Authors
Caffrey P, Lynch S, Flood E, Finnan S, Oliynyk M
  Title
Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.
  Journal
Chem Biol 8:713-23 (2001)
DOI:10.1016/S1074-5521(01)00046-1

  All links  
Gene (2)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
Protein sequence (1)   
   UniProt (1)   
DNA sequence (1)   
   GenBank (1)   
3D Structure (8)   
   PDB (8)   
Protein domain (18)   
   Pfam (18)   
Literature (1)   
   PubMed (1)   
Taxonomy (1)   
   TAX (1)   
All databases (32)   

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