KEGG   Ailuropoda melanoleuca (giant panda): 100464316
Entry
100464316         CDS       T01329                                 
Symbol
HMGCR
Name
(RefSeq) 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
  KO
K00021  hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34]
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
aml00900  Terpenoid backbone biosynthesis
aml01100  Metabolic pathways
aml04152  AMPK signaling pathway
aml04976  Bile secretion
Module
aml_M00095  C5 isoprenoid biosynthesis, mevalonate pathway
Brite
KEGG Orthology (KO) [BR:aml00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    100464316 (HMGCR)
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    100464316 (HMGCR)
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    100464316 (HMGCR)
Enzymes [BR:aml01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.34  hydroxymethylglutaryl-CoA reductase (NADPH)
     100464316 (HMGCR)
SSDB
Motif
Pfam: HMG-CoA_red Sterol-sensing Patched
Other DBs
NCBI-GeneID: 100464316
NCBI-ProteinID: XP_002917256
Ensembl: ENSAMEG00000000634
UniProt: D2H687
Position
3:50901356..50922632
AA seq 888 aa
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNDKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTAENSKVSLGLDENVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITAPVAT
PKKVPDDCCRREPILVRNSQQVHAAEEETRIKRERKVEVIKPVVAETDTPNRATFVVGDS
SSLDTSLELETQEPEIELPMEPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
LETLMETHERGVSIRRQLLSRKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV
AGPLRLDGKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRILADGMTRGPVVRLPRAC
DSAEVKAWLETPEGFTVMKEAFDSTSRFARLQKLHMSMAGRNLYIRFQSRSGDAMGMNMI
SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR
IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGTCTKKAA
NT seq 2667 nt   +upstreamnt  +downstreamnt
atgttgtcaagacttttccgaatgcacggcctttttgtggcctctcatccctgggaagtc
atagtggggacagtgacactgaccatctgtatgatgtccatgaacatgtttactggtaac
gataagatctgtggttggaattatgagtgtccgaagtttgaagaggatgtgttaagcagt
gacattataattctgacaataacacgatgcatagcaatcctgtatatttacttccagttc
cagaatttacgtcaacttggatcaaaatatattttgggtattgctggcctcttcacaatt
ttctctagttttgtgttcagtacagttgtcattcatttcttagataaagaattgacaggc
ttgaatgaagctttgccctttttccttcttttgattgacctttccagagcaagtgctcta
gcaaagtttgccctcagttccaactcacaggatgaagtgcgggaaaacatcgctcgtgga
atggcaattttaggtccaacattcacccttgatgctcttgtagaatgtctggtgattgga
gttggtaccatgtcaggggtgcgtcaacttgaaataatgtgctgctttggctgcatgtca
gttctggccaactacttcgtgttcatgactttcttcccagcttgcgtttccttggtttta
gagctttctcgggaaagccgtgagggtcgtccaatttggcaactgagccattttgctcga
gttttagaagaagaagaaaataaaccaaatcctgtcactcagagagttaagatgattatg
tctctaggcttggtccttgttcatgcccatagtcgctggatagctgatccttctcctcaa
aacagtacggcggaaaattctaaggtttctttaggattggatgaaaatgtgtccaagaga
attgaaccaagtgtttccctctggcagttttacctctctaaaatgatcagcatggatatt
gagcaagttattaccctaagtttagctctcctcctggctgtcaagtacatcttctttgaa
caagctgagacagaatcaacactctcattaaaaaaccctattacagctcctgtagcgact
cccaaaaaagtcccagatgattgttgtagacgtgaacctatactggtcagaaatagccag
caagtccatgcagcggaggaggagacaaggataaagagagaaagaaaagttgaggtcata
aaacccgtagtggcagaaactgacaccccaaacagagctacgtttgtggttggtgattcc
tcctcgcttgatacttcgctggaactagagacacaggaacctgaaattgaactccccatg
gagcctcgacctaatgaagaatgtctacagatacttgggaatgcagagaaaggtgcaaaa
ttccttagtgatgctgagatcatccaattagttaatgctaagcacatcccagcttacaaa
ttggaaactctgatggaaacccacgaacgaggtgtatctattcgccgacagttactttcc
agaaaacttccagagccttcttctctccagtatctaccgtatagggactataattactcc
ttggtgatgggagcttgttgtgagaatgttattggatatatgcccatccctgttggagtg
gcaggacctctgcgcttggatggaaaagagtttcaggttccgatggcaacaacagaaggt
tgtctcgtggccagcactaatcgaggctgccgagcaataggtcttggtggaggcgccagc
agtcgaatcctcgcagatgggatgactcgtggcccagtggtgcgtcttccccgtgcttgt
gactctgcggaagtgaaggcctggcttgaaacacctgaagggttcacagtgatgaaggag
gcttttgacagtaccagcagatttgcacgtctacagaaacttcatatgagtatggccggt
cgcaatctttatattcgtttccagtccaggtcaggtgatgccatggggatgaacatgatt
tcaaagggcacagagaaggcactttcaaaacttcatgagtatttccctgaaatgcagatt
ctagcagttagtggtaactactgtactgacaagaaacctgctgctataaactggatagag
ggaagaggaaagtctgtggtttgtgaagctgtcattccagccaaggttgtcagagaagta
ttaaagactactacagaagctatgattgaggtcaacattaataagaatctggtgggctct
gccatggccgggagtattggaggctacaatgcccatgcggcgaatatagtaactgccatc
tacattgcctgtggacaggatgcagcacaaaatgttggtagttcaaactgtattacttta
atggaagcaagtggtcccacaaatgaagatttgtatatcagttgcaccatgccatctata
gaaatcggaactgtgggtggtgggaccaacctgctccctcagcaagcctgtttgcagatg
ctcggtgttcaaggagcatgcaaagacaatcctggggaaaatgcccggcagcttgccagg
atcgtgtgcggtacagtaatggctggggaactgtcgctgatggcagcgttggcagccgga
catcttgtcaaaagtcacatgattcacaacaggtcaaagataaatttacaagacctccaa
ggaacttgcactaagaaggctgcttga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (4)   
   KEGG MODULE (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (3)   
   Pfam (3)   
All databases (34)   

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