KEGG   Bifidobacterium breve UCC2003: Bbr_0175
Entry
Bbr_0175          CDS       T02534                                 
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
  KO
K01649  2-isopropylmalate synthase [EC:2.3.3.13]
Organism
bbru  Bifidobacterium breve UCC2003
Pathway
bbru00290  Valine, leucine and isoleucine biosynthesis
bbru00620  Pyruvate metabolism
bbru01100  Metabolic pathways
bbru01110  Biosynthesis of secondary metabolites
bbru01210  2-Oxocarboxylic acid metabolism
bbru01230  Biosynthesis of amino acids
Module
bbru_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:bbru00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    Bbr_0175 (leuA)
  09105 Amino acid metabolism
   00290 Valine, leucine and isoleucine biosynthesis
    Bbr_0175 (leuA)
Enzymes [BR:bbru01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.13  2-isopropylmalate synthase
     Bbr_0175 (leuA)
SSDB
Motif
Pfam: HMGL-like LeuA_dimer CATIP_N DUF4953
Other DBs
NCBI-ProteinID: ABE94884
Position
246581..248497
AA seq 638 aa
MGQDQSSVFDLAAVAAASNGGNNDPLLPPARFIGDPQKPSRMPYNKYASYSEQIPFDYPE
RTWPGKRLQRAPRWCSVDLRDGNQALVNPMDSERKLRFWNLLVSMGFKEIEVGFPSASET
DFDFIRMLIERELIPDDVTIVVLTQCREHLIRRTYEALKGAKRAIVHFYNSVSVLQREVV
FKKNKEEIKKLATDAAELCKDLESEAKGIDLYYEYSPESFTGTEPEYAVEVCNAVIGVIK
PTPEHPMIINLPATVEMTTPNVFADEVEYVSTHLDDRDSVVLSLHPHNDEGMGVAATELA
VLAGADRVEGCLLGNGERTGNVDLVTLGLNWLTQGIDPQLDLSNVPEIRKTVEYCNQIKI
SERHPYAGNFVFTAFSGSHQDAIKKGLEARQVAAERAGADLDSFVWLVPYLPIDPKDIGR
TYEAIIRVNSQSGKGGMAYLLKTNHNLDLPKRLQIEFDKIVQNFADTTKKEVKDEDIWRL
FKDEYLPVEQSGMTAAGVVVGDTHDASLAPWGRLKLLKVSVSSGEDGSDTVLKARLLDRG
VNVGADGPVEREVSGIGNGPIAAFLNAISNFGVDASIMDYVEHTMSVGTDAMAASYVECQ
VGEADDAQIVWGVGIDSSITTSALKAIISAINRSQRNR
NT seq 1917 nt   +upstreamnt  +downstreamnt
atgggtcaggatcaatcatccgtgtttgatctcgcggccgtggccgcggcgtccaatggg
gggaacaacgacccactgctgcctccggcacggttcatcggcgatccgcagaagcccagc
cgtatgccgtacaacaagtacgcctcatacagcgagcagatcccgtttgattacccggag
cgcacgtggccgggcaagcgactgcagcgcgcaccgcgctggtgctccgtcgatcttcgc
gacggcaaccaggccctcgtcaacccgatggattccgagcgcaagctgcgcttctggaac
ctgctcgtctccatgggattcaaggagatcgaggtgggcttcccgtccgcatccgaaacc
gatttcgacttcatccgcatgctcatcgagcgcgagctcatcccggacgatgtgactatc
gtggtgctcacccagtgccgcgagcacctcatccgccgcacctacgaggcgctcaagggt
gccaagcgcgccatcgtgcacttctacaactccgtgtccgtgctgcagcgcgaagtggtg
ttcaagaagaacaaggaagagatcaagaagctcgccaccgacgccgccgaactatgcaag
gacctcgaatccgaggccaagggcatcgacctgtactacgagtactcgccggaatccttc
accggaaccgagccggagtacgccgttgaggtgtgcaacgccgtgatcggcgtcatcaag
cccacccccgagcatccgatgatcatcaatctgcccgccaccgtggaaatgaccacgccg
aacgtgttcgccgacgaagtggagtacgtctccacccacctcgacgaccgcgattccgtg
gtgctctccctccacccgcacaacgacgaaggcatgggcgtggccgccaccgagctggcc
gtgctggccggcgccgaccgcgtggaaggctgcctgctgggcaacggtgagcgcaccggc
aacgttgacctggtcacgctgggcctcaactggctcacccagggcatcgacccgcaactc
gacctgtccaacgtacctgagatccgcaagacggttgagtactgcaaccagatcaagatt
tccgagcgccatccgtacgccggcaacttcgtgttcaccgcgttctccggctcgcatcag
gacgccatcaagaagggtctcgaggcccgtcaggtggccgccgagcgcgccggcgccgat
ctcgacagcttcgtctggctcgtgccctacctgccgatcgatccgaaggacatcggccgc
acgtacgaggccatcatccgcgtcaactcgcagtccggcaagggcggcatggcatacctg
ctcaagaccaaccacaaccttgacctgccgaagcgtctgcagatcgaattcgacaagatt
gtgcagaacttcgccgacaccaccaagaaggaagtcaaggacgaggacatctggcgcttg
ttcaaggacgagtacctgccggtcgaacagtccggcatgaccgccgccggcgtggttgtg
ggcgatacccacgacgcttcgcttgcgccttggggccgcctgaagctgctcaaggtgtcc
gtaagctccggtgaggacggttccgacaccgtgctcaaggctcgcctgctcgaccgcggc
gtgaacgttggggccgatgggcccgtggagcgcgaggtgtccggcatcggcaacggtccg
atcgccgccttcctcaacgctatctccaacttcggcgtggatgcctcgattatggactac
gtggagcacaccatgtccgtgggcaccgacgctatggccgcctcttatgtggaatgccag
gtcggtgaggctgacgacgcgcagatcgtgtggggcgtgggcattgactcgtccattacc
accagcgcgctgaaggcgattatctccgccatcaaccgttcccagcgcaaccgctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   OC (1)   
Protein domain (4)   
   Pfam (4)   
All databases (24)   

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