KEGG   Bubalus bubalis (water buffalo): 102395073
Entry
102395073         CDS       T05912                                 
Symbol
TH
Name
(RefSeq) tyrosine 3-monooxygenase
  KO
K00501  tyrosine 3-monooxygenase [EC:1.14.16.2]
Organism
bbub  Bubalus bubalis (water buffalo)
Pathway
bbub00350  Tyrosine metabolism
bbub00790  Folate biosynthesis
bbub01100  Metabolic pathways
bbub04728  Dopaminergic synapse
bbub04917  Prolactin signaling pathway
bbub05012  Parkinson disease
bbub05030  Cocaine addiction
bbub05031  Amphetamine addiction
bbub05034  Alcoholism
Module
bbub_M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Brite
KEGG Orthology (KO) [BR:bbub00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    102395073 (TH)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    102395073 (TH)
 09150 Organismal Systems
  09152 Endocrine system
   04917 Prolactin signaling pathway
    102395073 (TH)
  09156 Nervous system
   04728 Dopaminergic synapse
    102395073 (TH)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    102395073 (TH)
  09165 Substance dependence
   05030 Cocaine addiction
    102395073 (TH)
   05031 Amphetamine addiction
    102395073 (TH)
   05034 Alcoholism
    102395073 (TH)
Enzymes [BR:bbub01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.2  tyrosine 3-monooxygenase
     102395073 (TH)
SSDB
Motif
Pfam: Biopterin_H TH_ACT TOH_N LTP_2
Other DBs
NCBI-GeneID: 102395073
NCBI-ProteinID: XP_025142716
EnsemblRapid: ENSBBUG00015018443
Position
5:130854002..130861018
AA seq 491 aa
MPTPNAASPQAKSFRRAVSELDAKQAEAIMSPRFVGRRQSLIQDARKEREKAEAAASSSE
SAESGSLVERDGKAVLTLLFALRPTKPPALTRAIKVFETFEAHLHHLETRPAQPPRAGSP
PLECFVRCEVPGPVVPALLSALRRVAEDVRAAGESKVLWFPRKVSELDTCHHLVTKFDPD
LDLDHPGFSDQAYRQRRKLIAEIAFQYKQGDPIPHVEYTAEETATWKEVYSTLRGLYPTH
ACREHLEAFELLERFCGYREDRIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFR
VFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGVSDEEIEKL
STLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHSLSEEPEIRAFDPDAAAVQPYQDQT
YQPVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPHAIRRALDGVQDEM
QALAHALNAIS
NT seq 1476 nt   +upstreamnt  +downstreamnt
atgcctacccccaacgccgcctcgccgcaggccaagagcttccgcagggccgtctccgag
ctggacgccaagcaggctgaggccatcatgtccccacgcttcgtcgggaggcggcagagc
ctcatccaggatgcacgcaaggagcgggagaaggcggaggccgcagcctcatcctcggag
tccgcggagtcgggcagcctggtggagagggacgggaaggcggtgctgaccctgctgttc
gccctgcggcccaccaagccccctgcgctgacccgggctatcaaggtgtttgagacattc
gaagcccacctccaccacctggagacccgaccagcccagccgccgcgggcggggagcccg
cccctggagtgcttcgtgcgctgtgaggtgcccggcccagtggtgcccgccctgctgagt
gccctgcgccgcgtggcagaagacgtgcgcgccgccggggagagcaaggtcctctggttc
ccgaggaaagtgtccgagctggacacgtgccaccacctcgtcaccaagtttgaccccgac
ctggacctggatcacccgggcttctccgaccaggcttaccgccagcgcaggaagctgatc
gccgagatcgccttccagtacaagcaaggcgaccccattccccacgtggagtacacagct
gaggagacagccacctggaaggaggtctactccacgctgcggggcctgtaccccacccac
gcctgccgcgagcacctggaggccttcgagctgctggagcgcttctgcgggtaccgcgaa
gaccgaatcccgcagctggaggatgtctcccgcttcctgaaggagaggaccggcttccag
ctgcggccggtggccggcctgctgtccgcgcgggacttcctggccagcctggcttttcgc
gtgttccagtgcacccagtacatccgccacgcctcctcgcccatgcactcccccgagccg
gactgctgccacgagctgctggggcacgtgcccatgctcgccgaccggaccttcgcgcag
ttttcccaggacatcgggctcgcatccttgggagtgtcggatgaggaaattgagaagctg
tccacgctgtactggttcaccgtggagtttgggctgtgcaaacagaatggagaagtgaag
gcctacggagcggggctgctgtcctcctacggggagctcctgcactccctttctgaggag
ccggagatccgggccttcgaccctgatgcagcggccgtgcagccctaccaggaccagacc
taccagcccgtctactttgtgtctgagagcttcagcgatgccaaggacaagctcaggagc
tacgcctcccgcatccagcgccccttctctgtgaagtttgacccgtacacactggccatc
gacgtgctggacagtccccacgccatccggcgtgccctggacggcgtccaggatgagatg
caggccctggcccacgctctgaacgccatcagctag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (10)   
   KEGG PATHWAY (9)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   ENSEMBLRAPID (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (3)   
   RefSeq(nuc) (1)   
   GenBank (1)   
   EMBL (1)   
Protein domain (4)   
   Pfam (4)   
All databases (35)   

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