KEGG   Bubalus bubalis (water buffalo): 102409054
Entry
102409054         CDS       T05912                                 
Symbol
HSD11B1
Name
(RefSeq) corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X2
  KO
K15680  corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]
Organism
bbub  Bubalus bubalis (water buffalo)
Pathway
bbub00140  Steroid hormone biosynthesis
bbub00980  Metabolism of xenobiotics by cytochrome P450
bbub01100  Metabolic pathways
bbub05204  Chemical carcinogenesis - DNA adducts
Module
bbub_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Brite
KEGG Orthology (KO) [BR:bbub00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    102409054 (HSD11B1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    102409054 (HSD11B1)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    102409054 (HSD11B1)
Enzymes [BR:bbub01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.146  11beta-hydroxysteroid dehydrogenase
     102409054 (HSD11B1)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR DUF1776 THF_DHG_CYH_C 2-Hacid_dh_C Pyr_redox_2 Shikimate_DH Pyr_redox_3 Methyltransf_25 FMO-like NAD_binding_2 ADH_zinc_N Pyr_redox
Other DBs
NCBI-GeneID: 102409054
NCBI-ProteinID: XP_025141176
Position
5:7343980..7417253
AA seq 338 aa
MSGKVHQALNFMLSQNSKDTLTGFLVSKLYCPSDLLLGLLVPDPCLMAFMKKYLLPILGI
FLAYYYYSANEEFRPEMLRGKRVIVTGASKGIGREMAYHLARMGAHVVVTARSEESLKKV
VSRCLELGAASAHYVAGTMENMTFAEQFVAKAGELVGGLDMLILNHIHYTPLGVFSNDIH
VLRRSLEVNLLSYVVLSTAALPMLKQTNGSIVVVSSIAGKIACPLAAAYSASKFALDGFF
SSLRTEYEATKVNVSITLCILGLIDTDTAMKAVAGIFNAKASPKEECALEIIKGGALRQD
EVYYDSSILTPLLLINPGRKIMEFFFLKNYNMERFINN
NT seq 1017 nt   +upstreamnt  +downstreamnt
atgtctgggaaagtacaccaagctctgaacttcatgctttctcaaaattcaaaagacaca
cttactggcttcctcgtgtccaaactctactgtccttcagatctgcttctagggctcctt
gtgccagatccctgtctgatggcttttatgaaaaaatacctcctccccatcctggggatc
ttcttggcctactactactattctgcaaatgaggaattcagaccagagatgcttcgagga
aagagagtgattgtcacgggggccagcaagggaatcggaagagaaatggcctatcacctg
gcaaggatgggagcccatgtggtagtgacagcgagatcagaagaaagtctaaagaaggtg
gtatcccgctgcctggagctgggggcggcctcagcacactacgtggcaggcaccatggag
aacatgaccttcgcagaacaatttgttgccaaagctggagagctcgtggggggacttgac
atgctcattctcaaccacatccactacacgcctttgggggtgtttagcaatgacatccat
gtcttgcgcagaagcctggaggtcaaccttctgagttatgtggtcctgagcacagccgcc
ttgcccatgctgaagcagaccaatgggagcattgtggtcgtctcctccatagctgggaaa
atagcttgtccacttgctgctgcatattctgcaagcaagtttgctctggatgggttcttc
tcctctctcaggacggaatatgaggcgaccaaggtcaatgtgtcaatcaccctctgtatt
cttggcctcattgacacagacacagccatgaaggcagttgctgggatatttaatgcaaaa
gcatctccaaaggaagaatgtgccctggagattatcaaagggggagctctgcgccaagat
gaagtctattatgacagttcaatcttgactcctcttctgctgataaatccaggaaggaag
atcatggaatttttcttcttgaagaactataatatggaaagatttataaacaactag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (13)   
   KEGG COMPOUND (13)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (5)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (8)   
   RefSeq(nuc) (2)   
   GenBank (3)   
   EMBL (3)   
Protein domain (14)   
   Pfam (14)   
All databases (54)   

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