KEGG   PATHWAY: biu04514
biu04514                    Pathway                                

Cell adhesion molecules - Bos indicus (zebu cattle)
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Environmental Information Processing; Signaling molecules and interaction
Pathway map
biu04514  Cell adhesion molecules

Other DBs
GO: 0050839
Bos indicus (zebu cattle) [GN:biu]
109555875  CD58; lymphocyte function-associated antigen 3 [KO:K06492]
109556769  lymphocyte function-associated antigen 3-like [KO:K06492]
109555873  CD2; T-cell surface antigen CD2 [KO:K06449]
109553685  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
109576990  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
109562902  CD274; programmed cell death 1 ligand 1 isoform X1 [KO:K06745]
109569809  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
109554436  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
109569818  CTLA4; cytotoxic T-lymphocyte protein 4 isoform X1 [KO:K06538]
109561071  ICOSLG; ICOS ligand [KO:K06710]
109569829  ICOS; inducible T-cell costimulator [KO:K06713]
109576545  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109576596  HLA class II histocompatibility antigen, DO alpha chain-like isoform X1 [KO:K06752]
109577038  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109577039  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
109577041  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109577042  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
109576666  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109577307  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
109577316  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
109576780  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109558922  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
109577067  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
109577074  BOLA class I histocompatibility antigen, alpha chain BL3-6-like isoform X1 [KO:K06751]
109577076  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
109577078  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
109577080  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
109577083  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
109577088  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
109577113  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
109576723  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
109561936  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
109566151  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
109566150  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
109562901  PDCD1LG2; programmed cell death 1 ligand 2 isoform X1 [KO:K06708]
109564754  CD276; CD276 antigen [KO:K06746]
109556768  VTCN1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747]
109556613  PDCD1; programmed cell death protein 1 isoform X1 [KO:K06744]
109567510  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
109555532  CD40LG; CD40 ligand [KO:K03161]
109568754  ALCAM; CD166 antigen isoform X1 [KO:K06547]
109554658  CD6; T-cell differentiation antigen CD6 isoform X1 [KO:K06456]
109572759  PVR; poliovirus receptor [KO:K06539]
109577994  CD226; CD226 antigen [KO:K06567]
109572641  NECTIN2; nectin-2 isoform X1 [KO:K06531]
109575725  TIGIT; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350]
109578145  ITGAL; integrin alpha-L [KO:K05718]
109560786  ITGB2; integrin beta-2 [KO:K06464]
109561581  intercellular adhesion molecule 1 [KO:K06490]
109573936  ICAM2; intercellular adhesion molecule 2 isoform X1 [KO:K06523]
109573938  intercellular adhesion molecule 2-like isoform X1 [KO:K06523]
109561585  ICAM3; intercellular adhesion molecule 3 [KO:K06486]
109572327  CD22; B-cell receptor CD22 isoform X1 [KO:K06467]
109570498  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:]
109567191  SIGLEC1; sialoadhesin isoform X1 [KO:K06548]
109578803  SPN; leukosialin [KO:K06477]
109554960  CLDN34; claudin-34 [KO:K06087]
109553313  putative claudin-24 [KO:K06087]
109556426  CLDN19; claudin-19 [KO:K06087]
109571458  CLDN5; claudin-5 [KO:K06087]
109573768  CLDN7; claudin-7 [KO:K06087]
109556261  CLDN8; claudin-8 [KO:K06087]
109553577  CLDN23; claudin-23 [KO:K06087]
109558215  CLDN11; claudin-11 [KO:K06087]
109555504  CLDN2; claudin-2 [KO:K06087]
109578644  CLDN6; claudin-6 [KO:K06087]
109578682  CLDN15; claudin-15 isoform X1 [KO:K06087]
109564632  CLDN18; claudin-18 [KO:K06087]
109578827  CLDN4; claudin-4 [KO:K06087]
109578849  CLDN3; claudin-3 [KO:K06087]
109578262  CLDN9; claudin-9 [KO:K06087]
109563836  CLDN17; claudin-17 [KO:K06087]
109566916  CLDN10; claudin-10 isoform X1 [KO:K06087]
109569480  CLDN25; putative claudin-25 [KO:K06087]
109556733  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
109556744  CLDN1; claudin-1 [KO:K06087]
109553468  claudin-22-like isoform X1 [KO:K06087]
109561521  CLDN14; claudin-14 [KO:K06087]
109564073  CLDN20; claudin-20 [KO:K06087]
109574987  OCLN; occludin [KO:K06088]
109578437  F11R; junctional adhesion molecule A isoform X1 [KO:K06089]
109559245  JAM2; junctional adhesion molecule B [KO:K06735]
109554463  JAM3; junctional adhesion molecule C [KO:K06785]
109554472  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
109573915  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
109555123  CD99L2; CD99 antigen-like protein 2 [KO:K06520]
109571485  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
109570715  SELP; P-selectin [KO:K06496]
109565881  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
109567924  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
109576217  ITGA9; integrin alpha-9 [KO:K06585]
109556011  vascular cell adhesion protein 1-like [KO:K06527]
109556012  vascular cell adhesion protein 1-like isoform X1 [KO:K06527]
109559043  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
109561258  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
109570717  SELL; L-selectin [KO:K06495]
109558673  glycosylation-dependent cell adhesion molecule 1 [KO:K06815]
109570522  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
109571601  GLG1; Golgi apparatus protein 1 [KO:K06816]
109570254  SELE; E-selectin [KO:K06494]
109568807  NECTIN1; LOW QUALITY PROTEIN: nectin-1 [KO:K06081]
109577925  CDH2; cadherin-2 [KO:K06736]
109562148  NCAM2; neural cell adhesion molecule 2 [KO:K06491]
109569890  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
109555392  L1CAM; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
109569654  CADM1; cell adhesion molecule 1 isoform X1 [KO:K06781]
109556165  NEGR1; neuronal growth regulator 1 [KO:K06775]
109570005  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
109566563  NTNG2; netrin-G2 [KO:K16359]
109557835  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
109556400  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:]
109571901  LRRC4B; leucine-rich repeat-containing protein 4B [KO:K16360]
109566354  SDC1; syndecan-1 [KO:K06257]
109568478  SDC2; syndecan-2 [KO:K16336]
109572676  SDC3; syndecan-3 [KO:K16337]
109567481  SDC4; syndecan-4 [KO:K16338]
109565743  ITGAV; integrin alpha-V [KO:K06487]
109557291  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
109567974  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
109565390  NRXN3; neurexin 3 isoform X1 [KO:K07377]
109562860  NLGN1; neuroligin-1 [KO:K07378]
109555491  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
109573240  NLGN2; neuroligin-2 [KO:K07378]
109578901  CADM3; cell adhesion molecule 3 isoform X1 [KO:K06780]
109557394  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
109559214  CNTN1; contactin-1 isoform X1 [KO:K06759]
109577771  PTPRM; receptor-type tyrosine-protein phosphatase mu [KO:K05693] [EC:]
109570098  NFASC; neurofascin [KO:K06757]
109573310  contactin-associated protein 1-like [KO:K07379]
109574304  contactin-associated protein 1 [KO:K07379]
109558029  CNTNAP2; contactin-associated protein-like 2 [KO:K07380]
109577593  MPZL1; myelin protein zero-like protein 1 isoform X1 [KO:K06770]
109578222  myelin protein P0 [KO:K06770]
109578251  LOW QUALITY PROTEIN: myelin protein P0-like [KO:K06770]
109572349  MAG; myelin-associated glycoprotein [KO:K06771]
109572856  cadherin-1 [KO:K05689]
109562307  VCAN; versican core protein isoform X1 [KO:K06793]
109566462  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
109572531  cadherin-3-like isoform X1 [KO:K06796]
109567280  CDH4; cadherin-4 [KO:K06797]
109572774  CDH15; cadherin-15 [KO:K06809]
109564194  NEO1; neogenin [KO:K06766]
Barclay AN.
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
Semin Immunol 15:215-23 (2003)
Sharpe AH, Freeman GJ.
The B7-CD28 superfamily.
Nat Rev Immunol 2:116-26 (2002)
Grewal IS, Flavell RA.
CD40 and CD154 in cell-mediated immunity.
Annu Rev Immunol 16:111-35 (1998)
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
J Immunol 175:1558-65 (2005)
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
Cell adhesion and polarity during immune interactions.
Immunol Rev 186:68-82 (2002)
Dejana E.
Endothelial cell-cell junctions: happy together.
Nat Rev Mol Cell Biol 5:261-70 (2004)
Bazzoni G.
The JAM family of junctional adhesion molecules.
Curr Opin Cell Biol 15:525-30 (2003)
Becker BF, Heindl B, Kupatt C, Zahler S.
Endothelial function and hemostasis.
Z Kardiol 89:160-7 (2000)
Elangbam CS, Qualls CW Jr, Dahlgren RR.
Cell adhesion molecules--update.
Vet Pathol 34:61-73 (1997)
Muller WA.
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
Trends Immunol 24:327-34 (2003)
Yamagata M, Sanes JR, Weiner JA.
Synaptic adhesion molecules.
Curr Opin Cell Biol 15:621-32 (2003)
Ethell IM, Pasquale EB.
Molecular mechanisms of dendritic spine development and remodeling.
Prog Neurobiol 75:161-205 (2005)
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
Making memories stick: cell-adhesion molecules in synaptic plasticity.
Trends Cell Biol 10:473-82 (2000)
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
Mol Cell Neurosci 19:292-306 (2002)
Dunican DJ, Doherty P.
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
Mol Cell Biol Res Commun 3:255-63 (2000)
Girault JA, Peles E.
Development of nodes of Ranvier.
Curr Opin Neurobiol 12:476-85 (2002)
Arroyo EJ, Scherer SS.
On the molecular architecture of myelinated fibers.
Histochem Cell Biol 113:1-18 (2000)
Salzer JL.
Polarized domains of myelinated axons.
Neuron 40:297-318 (2003)
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
Roles and modes of action of nectins in cell-cell adhesion.
Semin Cell Dev Biol 15:643-56 (2004)
Nakanishi H, Takai Y.
Roles of nectins in cell adhesion, migration and polarization.
Biol Chem 385:885-92 (2004)
Siu MK, Cheng CY.
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
Biol Reprod 71:375-91 (2004)
Lee NP, Cheng CY.
Adaptors, junction dynamics, and spermatogenesis.
Biol Reprod 71:392-404 (2004)
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
Development 132:1525-37 (2005)
Marthiens V, Gavard J, Lambert M, Mege RM.
Cadherin-based cell adhesion in neuromuscular development.
Biol Cell 94:315-26 (2002)
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
J Cell Sci 118:2355-62 (2005)
biu04520  Adherens junction
biu04530  Tight junction
biu04610  Complement and coagulation cascades
biu04660  T cell receptor signaling pathway
biu04670  Leukocyte transendothelial migration
KO pathway

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