KEGG   PATHWAY: biu04612
Entry
biu04612                    Pathway                                

Name
Antigen processing and presentation - Bos indicus (zebu cattle)
Class
Organismal Systems; Immune system
Pathway map
biu04612  Antigen processing and presentation
biu04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109558719  IFNG; interferon gamma [KO:K04687]
109577428  TNF; tumor necrosis factor [KO:K03156]
109564783  PSME1; proteasome activator complex subunit 1 isoform X1 [KO:K06696]
109564782  PSME2; proteasome activator complex subunit 2 [KO:K06697]
109573625  PSME3; proteasome activator complex subunit 3 [KO:K06698]
109565247  HSPA2; heat shock-related 70 kDa protein 2 [KO:K03283]
109577025  heat shock 70 kDa protein 1-like [KO:K03283]
109577026  heat shock 70 kDa protein 1A isoform X1 [KO:K03283]
109578169  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
109569622  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
109562010  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
109575457  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
109577125  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
109577067  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
109577074  BOLA class I histocompatibility antigen, alpha chain BL3-6-like isoform X1 [KO:K06751]
109577076  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
109577078  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
109577080  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
109577083  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
109577088  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
109577113  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
109576723  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
109561936  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
109566467  HSPA5; LOW QUALITY PROTEIN: 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
109565431  LOW QUALITY PROTEIN: beta-2-microglobulin-like [KO:K08055]
109565432  beta-2-microglobulin [KO:K08055]
109575507  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
109561526  CALR; calreticulin [KO:K08057]
109576595  TAPBP; tapasin [KO:K08058]
109577139  TAP1; antigen peptide transporter 1 [KO:K05653]
109577140  LOW QUALITY PROTEIN: antigen peptide transporter 2-like [KO:K05654]
109577300  antigen peptide transporter 2-like [KO:K05654]
109566151  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
109566150  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
109571857  LOW QUALITY PROTEIN: putative killer cell immunoglobulin-like receptor like protein KIR3DP1 [KO:K07980]
109559659  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
109559660  LOW QUALITY PROTEIN: NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
109559662  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
109558578  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
109558579  uncharacterized protein LOC109558579 [KO:K06541]
109559666  natural killer cells antigen CD94 isoform X1 [KO:K06516]
109559668  natural killer cells antigen CD94-like isoform X1 [KO:K06516]
109561419  IFI30; gamma-interferon-inducible lysosomal thiol reductase [KO:K08059]
109562776  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
109576545  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109576596  HLA class II histocompatibility antigen, DO alpha chain-like isoform X1 [KO:K06752]
109577038  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109577039  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
109577041  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109577042  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
109576666  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109577307  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
109577316  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
109576780  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109562203  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
109563231  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
109555340  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
109558922  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
109578694  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
109555052  RFX5; DNA-binding protein RFX5 isoform X1 [KO:K08061]
109561381  RFXANK; DNA-binding protein RFXANK isoform X1 [KO:K08062]
109566774  RFXAP; regulatory factor X-associated protein [KO:K08063]
109570093  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
109577002  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
109559460  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
109556440  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
Reference
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
biu03050  Proteasome
biu04650  Natural killer cell mediated cytotoxicity
biu04660  T cell receptor signaling pathway
KO pathway
ko04612   

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