KEGG   Bos indicus (zebu cattle): 109564199
Entry
109564199         CDS       T04792                                 

Gene name
ADCY4
Definition
(RefSeq) adenylate cyclase type 4
  KO
K08044  adenylate cyclase 4 [EC:4.6.1.1]
Organism
biu  Bos indicus (zebu cattle)
Pathway
biu00230  Purine metabolism
biu01100  Metabolic pathways
biu01522  Endocrine resistance
biu04015  Rap1 signaling pathway
biu04020  Calcium signaling pathway
biu04022  cGMP-PKG signaling pathway
biu04024  cAMP signaling pathway
biu04062  Chemokine signaling pathway
biu04072  Phospholipase D signaling pathway
biu04114  Oocyte meiosis
biu04211  Longevity regulating pathway
biu04213  Longevity regulating pathway - multiple species
biu04261  Adrenergic signaling in cardiomyocytes
biu04270  Vascular smooth muscle contraction
biu04371  Apelin signaling pathway
biu04540  Gap junction
biu04611  Platelet activation
biu04713  Circadian entrainment
biu04714  Thermogenesis
biu04723  Retrograde endocannabinoid signaling
biu04724  Glutamatergic synapse
biu04725  Cholinergic synapse
biu04727  GABAergic synapse
biu04742  Taste transduction
biu04750  Inflammatory mediator regulation of TRP channels
biu04911  Insulin secretion
biu04912  GnRH signaling pathway
biu04913  Ovarian steroidogenesis
biu04914  Progesterone-mediated oocyte maturation
biu04915  Estrogen signaling pathway
biu04916  Melanogenesis
biu04918  Thyroid hormone synthesis
biu04921  Oxytocin signaling pathway
biu04923  Regulation of lipolysis in adipocytes
biu04925  Aldosterone synthesis and secretion
biu04926  Relaxin signaling pathway
biu04927  Cortisol synthesis and secretion
biu04928  Parathyroid hormone synthesis, secretion and action
biu04934  Cushing syndrome
biu04935  Growth hormone synthesis, secretion and action
biu04970  Salivary secretion
biu04971  Gastric acid secretion
biu04972  Pancreatic secretion
biu04976  Bile secretion
biu05032  Morphine addiction
biu05163  Human cytomegalovirus infection
biu05166  Human T-cell leukemia virus 1 infection
biu05200  Pathways in cancer
biu05414  Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:biu00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    109564199 (ADCY4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    109564199 (ADCY4)
   04371 Apelin signaling pathway
    109564199 (ADCY4)
   04020 Calcium signaling pathway
    109564199 (ADCY4)
   04072 Phospholipase D signaling pathway
    109564199 (ADCY4)
   04024 cAMP signaling pathway
    109564199 (ADCY4)
   04022 cGMP-PKG signaling pathway
    109564199 (ADCY4)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    109564199 (ADCY4)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    109564199 (ADCY4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    109564199 (ADCY4)
   04062 Chemokine signaling pathway
    109564199 (ADCY4)
  09152 Endocrine system
   04911 Insulin secretion
    109564199 (ADCY4)
   04923 Regulation of lipolysis in adipocytes
    109564199 (ADCY4)
   04912 GnRH signaling pathway
    109564199 (ADCY4)
   04913 Ovarian steroidogenesis
    109564199 (ADCY4)
   04915 Estrogen signaling pathway
    109564199 (ADCY4)
   04914 Progesterone-mediated oocyte maturation
    109564199 (ADCY4)
   04921 Oxytocin signaling pathway
    109564199 (ADCY4)
   04926 Relaxin signaling pathway
    109564199 (ADCY4)
   04935 Growth hormone synthesis, secretion and action
    109564199 (ADCY4)
   04918 Thyroid hormone synthesis
    109564199 (ADCY4)
   04928 Parathyroid hormone synthesis, secretion and action
    109564199 (ADCY4)
   04916 Melanogenesis
    109564199 (ADCY4)
   04925 Aldosterone synthesis and secretion
    109564199 (ADCY4)
   04927 Cortisol synthesis and secretion
    109564199 (ADCY4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    109564199 (ADCY4)
   04270 Vascular smooth muscle contraction
    109564199 (ADCY4)
  09154 Digestive system
   04970 Salivary secretion
    109564199 (ADCY4)
   04971 Gastric acid secretion
    109564199 (ADCY4)
   04972 Pancreatic secretion
    109564199 (ADCY4)
   04976 Bile secretion
    109564199 (ADCY4)
  09156 Nervous system
   04724 Glutamatergic synapse
    109564199 (ADCY4)
   04727 GABAergic synapse
    109564199 (ADCY4)
   04725 Cholinergic synapse
    109564199 (ADCY4)
   04723 Retrograde endocannabinoid signaling
    109564199 (ADCY4)
  09157 Sensory system
   04742 Taste transduction
    109564199 (ADCY4)
   04750 Inflammatory mediator regulation of TRP channels
    109564199 (ADCY4)
  09149 Aging
   04211 Longevity regulating pathway
    109564199 (ADCY4)
   04213 Longevity regulating pathway - multiple species
    109564199 (ADCY4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    109564199 (ADCY4)
   04714 Thermogenesis
    109564199 (ADCY4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109564199 (ADCY4)
  09165 Substance dependence
   05032 Morphine addiction
    109564199 (ADCY4)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy (DCM)
    109564199 (ADCY4)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    109564199 (ADCY4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109564199 (ADCY4)
   05163 Human cytomegalovirus infection
    109564199 (ADCY4)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    109564199 (ADCY4)
Enzymes [BR:biu01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     109564199 (ADCY4)
SSDB
Motif
Pfam: Guanylate_cyc DUF1053 AC_N CD52
Other DBs
NCBI-GeneID: 109564199
NCBI-ProteinID: XP_019823303
Position
10
AA seq 1039 aa
MARLFSPRQPPSEDLFYETYYSLSQQYPLLLLLLLIVLLGLLALLPVAWASGRELAADPA
FLTTVLCALGGFSLLLVLASREQRLQRWTRPLSGLVWAALLALGHSFLFTGGVVSAWDQV
SFFLFVIFTVYAMLPLDMRDAITAGVTSSLSHLLVLGLYLGPQPDSRPALLPQLAANAVL
FLCGNAAGAYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMK
EEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE
LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATG
VDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEASGVPGCPHMAQAAEEDEKG
TAGGLLSSLEGSKMRPSLLMTRYLESWGAAKPFAHLSHVESPVSTSTPLPEKALSSFSPQ
WSLDRSRTMRGPDEELDTGDAKFFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRL
SALPAFKYYAACTFLVFLSNFIIQMLVTNRPPALTITYGITFLLFFLLLFVCFSEHLMKC
VLKGPKMLHWLPTLSVLVATRPGLRVALGTATILLVFVMAITSLVFLPATSACPFQAPNM
SSMASNLSWELPGSLPLISIPYSMHCCVLGFLSCSLFLHMSFELKLLLLLLWLTASCSIF
LHSHAWLSDCLIARLYLGTLDSRPGVLKEPKLMGAVSFFIFFFTLLVLARQNEYYCRLDF
LWKKKLRQEQEETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFAS
VPDFKEFYSESSINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTICSTYMAATGLN
ATSGQDAQQDAEQSCGHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIG
AQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGIIKVKGKGQLC
TYFLNTDLTRTGPPSATLG
NT seq 3120 nt   +upstreamnt  +downstreamnt
atggcccgcctcttcagtccacggcagccccccagcgaagacctcttctacgagacctac
tacagcttgagccagcagtacccactgctgctgctgctgctgctgatcgtgctcttgggg
ctcctggcgctgctccctgtggcctgggcaagtggcagggagctggccgcagacccagcc
ttcctgaccactgtgctgtgcgctctgggtggcttctcactgctgctggtcctggcttcc
cgggagcagcgactgcagcgctggacgcgtcccctgtcaggcctcgtgtgggcagcactg
cttgcactaggccacagcttcctgttcactgggggcgtggtgagcgcctgggaccaggtg
tcctttttcctttttgtcatcttcactgtgtatgccatgttgcccttggacatgcgggac
gccatcaccgcgggtgtcacctcctcactctcacacttgctggtccttgggctgtatctt
gggcctcagcccgactctcggccggcgctgctgccacagctggctgcaaacgcggtgctg
ttcctgtgcgggaacgcggccggagcctatcacaaggcgctgatggagcgcgcgctgcgc
gccacgttccgggaggcgcttagttccctgcactcgcggcggagactggacaccgagaag
aagcatcaggaacaccttctcttgtccatccttcctgcctacctggcccgagagatgaag
gaggagatcatggcacggctgcaggctggacaggggtcacggccagagagcaccaacaac
tttcacagcctctatgtcaagaggcaccagggagtcagcgtgctgtatgctgacatcgtg
ggcttcacgagactggccagtgagtgctcccctaaggagttggtgcttatgctcaacgag
ctctttggcaagttcgaccaaatcgccaaggagcacgaatgcatgcggatcaagatccta
ggagactgttactactgtgtctccggcctgccgctctcactgcctgaccacgccatcaac
tgtgtgcgcatggggctggacatgtgccgggccatcaggaaacttcgggcagccacaggc
gtggatatcaacatgcgtgtgggcgtgcactcaggcagcgtgctctgcggggtcatcggg
ctacagaaatggcagtatgatgtctggtcccatgacgtcactctggccaaccacatggag
gcgagtggagtgccagggtgccctcatatggcccaggctgcagaggaggacgagaagggt
actgcaggagggttgctgtcctctcttgagggctccaagatgcgtccatcactgctgatg
acccgctacctggagtcctggggtgcagccaagcctttcgcccacctgagccacgtagag
agccctgtgtccacatctacccctctcccggagaaggccctgtcttccttcagcccccag
tggagcctggaccggagccgtaccatgaggggacctgatgaggaattagacactggggat
gccaagttcttccaggtcatcgaacagctcaattctcagaaacaatggaaacagtcaaag
gacttcaatccactgacactgtacttcagagagaaggagatggagaaagagtatcggctc
tctgcactccccgccttcaaatactatgcagcctgcaccttcctggtttttctctccaac
ttcattatccagatgctggtgacaaacaggcctccagctctgaccatcacctatggcatc
accttcctcctcttcttcctcctcctcttcgtctgcttctcagagcacctgatgaagtgt
gtcttgaaaggccccaagatgctgcactggctacccaccctgtctgtcctggtggccaca
cggccaggactgcgagtggctctgggcaccgctaccatcctgctcgtcttcgtcatggcc
attaccagtctggtcttcttaccagcaacatcagcctgcccttttcaggctcccaatatg
tcctccatggcttccaacctctcctgggagctccctgggtccctgcctctcatcagcatc
ccatactccatgcactgctgcgtgttgggcttcctctcctgctccctcttcctgcacatg
agctttgagctgaagctgctgctgctcctgctgtggctgacggcctcctgctccatcttc
ctgcactcccacgcctggttgtccgactgcctcatcgcccgcctctacctgggcaccttg
gactccaggccaggggtgctgaaggagcccaaactgatgggagcagtctccttcttcatc
ttcttcttcaccctcctagtcctggctcggcagaacgaatattactgccgcctggacttt
ctgtggaagaagaagctgaggcaagagcaggaggagacagagacaatggagaacctgact
cggctgctcttggagaacgtgctccctgcgcacgtggccccccagttcattggtcagaat
cggcgcaatgaggacctctaccaccagtcctatgagtgtgtgtgtgtcctcttcgcctcg
gtcccagacttcaaggagttctactctgaatccagcatcaaccatgaggggctagagtgt
ctgcggctgctcaatgagataatcgctgattttgatgagctgctctccaagcccaagttc
agtggggtggagaagatcaaaactatctgcagcacctacatggcagctaccggcttgaac
gccacctctggacaggatgcacagcaggatgctgagcaaagctgcggccaccttggcacc
atggtagagtttgctgtggcccttgggtctaagctggatgtcatcaacaagcactcattc
aacaactttcgcttgcgtgtagggttaaaccacggacctgtagtggctggagtgattggg
gcccagaaaccacaatatgacatctggggcaacacggtgaatgtggccagccgcatggag
agcacaggtgtcctgggcaagattcaggtaacagaagagacagcctgggccctccagtcc
ttaggctacacctgctacagccggggcatcatcaaggtcaaaggcaaagggcagctctgc
acctacttcttgaacacagatttgacacgaactggacctccctcagccaccctaggctga

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