KEGG   Bos mutus (wild yak): 102273597
Entry
102273597         CDS       T02919                                 
Symbol
IRS4
Name
(RefSeq) insulin receptor substrate 4
  KO
K17446  insulin receptor substrate 4
Organism
bom  Bos mutus (wild yak)
Pathway
bom04022  cGMP-PKG signaling pathway
bom04068  FoxO signaling pathway
bom04140  Autophagy - animal
bom04152  AMPK signaling pathway
bom04211  Longevity regulating pathway
bom04213  Longevity regulating pathway - multiple species
bom04910  Insulin signaling pathway
bom04920  Adipocytokine signaling pathway
bom04923  Regulation of lipolysis in adipocytes
bom04930  Type II diabetes mellitus
bom04935  Growth hormone synthesis, secretion and action
bom05010  Alzheimer disease
Brite
KEGG Orthology (KO) [BR:bom00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    102273597 (IRS4)
   04022 cGMP-PKG signaling pathway
    102273597 (IRS4)
   04152 AMPK signaling pathway
    102273597 (IRS4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102273597 (IRS4)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    102273597 (IRS4)
   04923 Regulation of lipolysis in adipocytes
    102273597 (IRS4)
   04920 Adipocytokine signaling pathway
    102273597 (IRS4)
   04935 Growth hormone synthesis, secretion and action
    102273597 (IRS4)
  09149 Aging
   04211 Longevity regulating pathway
    102273597 (IRS4)
   04213 Longevity regulating pathway - multiple species
    102273597 (IRS4)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102273597 (IRS4)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102273597 (IRS4)
SSDB
Motif
Pfam: IRS PH_11
Other DBs
NCBI-GeneID: 102273597
NCBI-ProteinID: XP_005910907
Position
Un
AA seq 1319 aa
MKEEAHFENLAVICVPHTRGLLSGLEQARECLQRGGRQALPLAPTPSNENLATVSPGFYF
PNKQTSRPGTLPALLPGAARDRCAPPPPATSRPLQPIEPARGAPAPPPSPAALSSAPLEL
LLILPPPPVRASLGSSLGPAWPRAPPPPPGSRSDSESDEEDLPVGDEVCKRGYLRKQKHG
HWRYFVLKLETADAPARLEYYENARKFRHSVRAADGNPHRTHWDRDARYPHLIALFTQNE
YFAMVAENESEQESWYLLLSRLILESKRRRCGRLGAQPEGEPAALAAAAAAEPPFYKDVW
QVIVKPRGLGHRKELSGVFRLCLTDEEVLFVRLNTEVASVVVQLLSIRRCGHSEQYFFLE
VGRSTVIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGGHLLTLL
STRRHLDMLPLEPGGWFRRSRFEQFCHLRAIGDGEDEMLLAGRYITPSEPVPRSRRGRLH
LPRGRRSRRATSVPASFFRRAAPSPVRIRYPAEALHDRDPVSSEASSSGSGNSGEEGGPQ
RKEDQEENEGDYMPMNNWGSGNGRGSGSGQGSSGQGSSSQSSGGSQCSGRGHGSGGGQGS
SSSHGSSGSGSGDQSAGGNQCSGDGQGTAGHGSGSGQGAGGGHGSGRDQGAGDGHGSGGG
KNSGGGKGSGSGKGPEGNGDRGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPGAATGGKG
KSGGRFRLYFCADRGATKERKEAKEVKDTEPPEGAARGPHRARAFDEDEDDPYVPMRPGV
AAPLASSSDYMPMAPQNVSVSKKRHSRSPFEDSRGYMMMFPRVSPPPVPSPPKEPDPAKE
DDSKDNDSDSDYMFMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQSDHSE
YVPMLPGKFLGKGLEKEVSSNRGPKDTASKPSVKGSFSKPRDGGSPSKRSGDGPPKNKAK
RPNRLPFMTKGNKVKPKPQKPTQEQREADSPRGYVNIDFPKRGYNMPDPCLQRLPGVWGI
IADPRQFAFSNYVNVEFGVPFPNPADNLSDFFRAIPGANPFFLDGATGSSANREEGDYIE
VIFNPAMTPAVPFADSAIRYDAETGRIYVVDPFSECCMNISLSPSRCSERPPVARLLLLE
ELDRRRPQSRSQSFFAAARAAISAFPADSLERDLSASFAAAAAAVPTLVLGRALAAASAL
VAAPGIGAAAAGLEAAAGFDSASVRWFLPVADAAGAAVRGAQDIAGGSNPRPPNPSADLA
GGENRAGGAAAAVAAAPRSPGRGRVPRPPEREDSDDDDTYVRMDFARRDNGKFDSPQRE
NT seq 3960 nt   +upstreamnt  +downstreamnt
atgaaagaggaggctcattttgaaaacctcgctgttatttgtgtgccccacacccgcggg
cttttatcagggctggagcaggctcgcgagtgcctgcagcgcggtgggcggcaggccctc
ccattggctcccaccccatccaatgagaatcttgcaacagtttcacctggcttctacttt
ccaaataaacaaacaagccgtcccgggaccctgccagctctcctccccggcgccgcccga
gatcgttgtgctccgccccctcccgccacctctcgccccctccagccaatcgagcccgcc
cgtggtgcccccgccccgccgccgtctccggccgctctctcctccgcccctctcgaactt
ctcctgatactccccccacccccagtccgtgcctccttggggtcctcgttaggaccagcg
tggccaagggccccgcctcctcccccgggctcccggtcagactcggagtccgacgaggag
gaccttcccgtcggggacgaagtctgcaaacgcggctacctgcggaagcagaagcatggg
cactggcgctacttcgtgctcaaactcgagacagccgacgccccagctcggctggaatac
tacgaaaatgccaggaagttccggcacagtgtccgcgccgcggacgggaacccccaccgc
actcattgggaccgggacgcaaggtacccacacctcattgctcttttcacccaaaacgag
tatttcgcaatggtggcagagaatgagtcggagcaagagagctggtacttgctgctcagc
cgcctcatcctcgagagcaagcgccgccgctgcggcaggctcggcgcgcagccggaggga
gagccggccgcgctagcagctgcagcggcggcagagccacccttctacaaagatgtgtgg
caagtaatagtcaaacccagggggctggggcaccgaaaagagctgagcggcgtgttccgg
ctctgtcttaccgacgaggaggttctgtttgtgaggttaaataccgaagtggccagcgtg
gttgtccagctcctgagcatccgtcgctgtgggcactcggagcagtatttcttcttggaa
gtcggcaggtccaccgtcatcggtccgggggagctctggatgcaagtggatgactgtgtc
gtggcccaaaacatgcacgagctgtttttggagaagatgagagccttgtgtgcagacgaa
tacagagcccgctgccgcagctacagcatcagcatcggcggccacctgttaaccctgctg
tccactaggaggcacctggacatgctgccgctcgagcccggcggctggttccgaaggtcc
cgctttgagcagttttgccaccttcgggccatcggtgacggggaagacgaaatgctcctc
gccgggcgctacataacacccagtgagccagtgccccgctccagacgaggaagactacac
ctgcccagagggcgcagatccaggagagcgacttcagtgccagccagctttttccgccgc
gccgctcccagccctgtgcgcatccggtaccctgcagaagccctccacgaccgagatccc
gtgtcttctgaagcctctagttctggctctggcaattcaggggaagaaggcggtcctcag
cgcaaagaggatcaggaagaaaacgaaggtgactatatgcccatgaacaactggggctcg
ggaaatggccggggctcaggaagtggacagggttcaagtgggcaaggctccagtagccaa
agctccgggggaagtcagtgctcaggcagggggcatggctccggaggtggtcagggctca
agtagcagccatggctcaagtggcagcggttccggggaccagagtgcaggaggaaaccag
tgctctggggatggccagggcaccgctgggcatggctcaggcagtggccagggagctgga
ggtgggcatggctcaggccgtgaccagggagccggagatggccatggctcaggcggtggc
aagaactctggagggggcaaaggctcagggagtgggaaggggcctgaaggcaatggtgat
cgtgggaaatctctgaagaaaagatcctactttggcaaattaactcaaagcaagcaacag
caaatgccaccacctccgccccctccacccccaccaggtgcagcaactggtggcaaaggg
aagtctgggggaaggttccgactttatttttgtgcagacagaggggccacaaaagaacgc
aaagaagccaaagaagtgaaagacacagagcccccagaaggtgcagctcggggtccccac
agagccagagcttttgatgaagacgaggatgatccgtatgtgccaatgaggccaggcgtg
gctgctcctctcgcaagctccagtgactacatgcccatggctcctcaaaatgtctctgtg
tccaaaaagcgccactctcgatcaccttttgaagattctagagggtacatgatgatgttt
cccagagtgagcccaccacctgtgccaagtcctccaaaagaacctgatcctgctaaagag
gacgactcaaaggacaatgacagtgacagtgactatatgttcatggcccctggagctggt
gccattcctaaaaaccccagaaatcctcagggaggctcttcctccaaaagttggagctcc
tacttctctctgccaaatccttttcggagctccccattgggacagagtgaccacagtgag
tatgtaccaatgttacctggaaaattcctaggaaagggcctagagaaggaagtctcatct
aacagaggccccaaagatacagcttcaaagccttcagtcaaagggtctttctcaaagcct
agagatgggggatcaccttccaagcgttcaggtgacgggccccccaagaacaaggctaag
agacctaatcgacttccttttatgacaaaaggaaacaaagtcaagccaaaaccacaaaag
cccacacaggagcagagagaagccgacagccccaggggctacgtcaacattgacttccct
aagagaggttataatatgccagatccatgtcttcaaagacttccaggtgtgtggggcata
attgccgaccccagacagtttgccttttccaattacgtgaatgttgagttcggagtgcca
tttccaaatccagcagacaacctctcagatttcttcagagctatcccaggtgccaatccc
ttctttctggacggtgctaccgggagcagtgctaatagggaagaaggtgactacatcgaa
gtgattttcaacccagcgatgacaccagctgtgccttttgctgacagtgccattcgctac
gatgccgaaactggtcgcatctacgtggtcgacccattttctgagtgctgtatgaacatt
tctctctcccccagccgctgctccgaacgaccacctgtagcgaggctgctactgctagaa
gagctcgatcgaaggcgcccacaaagccgttcgcaaagtttctttgcagccgccagagcc
gccatctctgctttccctgcagacagcctcgagagagacctatccgcctccttcgccgcg
gccgcggccgccgtgccaaccttagtcctgggccgggctttagccgccgcctccgctttg
gtcgcggctcccggcatcggcgcagcagccgccggcctcgaggccgccgctggatttgac
tccgcctccgtccgctggttcctacctgttgccgatgctgctggtgccgcggtcaggggg
gcccaagacattgcgggtggctcgaaccccagacccccaaacccatcagcagacctggcc
ggaggtgagaaccgagccggtggggctgctgctgcagtcgccgctgcgcctcgatcacct
ggccgcggccgggtgcccagacccccagagcgagaagattctgacgacgacgacacgtac
gtgagaatggactttgcaagacgtgacaacgggaagttcgactctccccaaagagagtga

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (12)   
   KEGG PATHWAY (12)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (2)   
   Pfam (2)   
All databases (22)   

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