KEGG   Bos mutus (wild yak): 102286168
Entry
102286168         CDS       T02919                                 

Gene name
ADCY4
Definition
(RefSeq) adenylate cyclase 4
  KO
K08044  adenylate cyclase 4 [EC:4.6.1.1]
Organism
bom  Bos mutus (wild yak)
Pathway
bom00230  Purine metabolism
bom01100  Metabolic pathways
bom01522  Endocrine resistance
bom04015  Rap1 signaling pathway
bom04020  Calcium signaling pathway
bom04022  cGMP-PKG signaling pathway
bom04024  cAMP signaling pathway
bom04062  Chemokine signaling pathway
bom04072  Phospholipase D signaling pathway
bom04114  Oocyte meiosis
bom04211  Longevity regulating pathway
bom04213  Longevity regulating pathway - multiple species
bom04261  Adrenergic signaling in cardiomyocytes
bom04270  Vascular smooth muscle contraction
bom04371  Apelin signaling pathway
bom04540  Gap junction
bom04611  Platelet activation
bom04713  Circadian entrainment
bom04714  Thermogenesis
bom04723  Retrograde endocannabinoid signaling
bom04724  Glutamatergic synapse
bom04725  Cholinergic synapse
bom04727  GABAergic synapse
bom04742  Taste transduction
bom04750  Inflammatory mediator regulation of TRP channels
bom04911  Insulin secretion
bom04912  GnRH signaling pathway
bom04913  Ovarian steroidogenesis
bom04914  Progesterone-mediated oocyte maturation
bom04915  Estrogen signaling pathway
bom04916  Melanogenesis
bom04918  Thyroid hormone synthesis
bom04921  Oxytocin signaling pathway
bom04923  Regulation of lipolysis in adipocytes
bom04925  Aldosterone synthesis and secretion
bom04926  Relaxin signaling pathway
bom04927  Cortisol synthesis and secretion
bom04928  Parathyroid hormone synthesis, secretion and action
bom04934  Cushing syndrome
bom04935  Growth hormone synthesis, secretion and action
bom04970  Salivary secretion
bom04971  Gastric acid secretion
bom04972  Pancreatic secretion
bom04976  Bile secretion
bom05032  Morphine addiction
bom05163  Human cytomegalovirus infection
bom05166  Human T-cell leukemia virus 1 infection
bom05200  Pathways in cancer
bom05414  Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:bom00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    102286168 (ADCY4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    102286168 (ADCY4)
   04371 Apelin signaling pathway
    102286168 (ADCY4)
   04020 Calcium signaling pathway
    102286168 (ADCY4)
   04072 Phospholipase D signaling pathway
    102286168 (ADCY4)
   04024 cAMP signaling pathway
    102286168 (ADCY4)
   04022 cGMP-PKG signaling pathway
    102286168 (ADCY4)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    102286168 (ADCY4)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    102286168 (ADCY4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102286168 (ADCY4)
   04062 Chemokine signaling pathway
    102286168 (ADCY4)
  09152 Endocrine system
   04911 Insulin secretion
    102286168 (ADCY4)
   04923 Regulation of lipolysis in adipocytes
    102286168 (ADCY4)
   04912 GnRH signaling pathway
    102286168 (ADCY4)
   04913 Ovarian steroidogenesis
    102286168 (ADCY4)
   04915 Estrogen signaling pathway
    102286168 (ADCY4)
   04914 Progesterone-mediated oocyte maturation
    102286168 (ADCY4)
   04921 Oxytocin signaling pathway
    102286168 (ADCY4)
   04926 Relaxin signaling pathway
    102286168 (ADCY4)
   04935 Growth hormone synthesis, secretion and action
    102286168 (ADCY4)
   04918 Thyroid hormone synthesis
    102286168 (ADCY4)
   04928 Parathyroid hormone synthesis, secretion and action
    102286168 (ADCY4)
   04916 Melanogenesis
    102286168 (ADCY4)
   04925 Aldosterone synthesis and secretion
    102286168 (ADCY4)
   04927 Cortisol synthesis and secretion
    102286168 (ADCY4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102286168 (ADCY4)
   04270 Vascular smooth muscle contraction
    102286168 (ADCY4)
  09154 Digestive system
   04970 Salivary secretion
    102286168 (ADCY4)
   04971 Gastric acid secretion
    102286168 (ADCY4)
   04972 Pancreatic secretion
    102286168 (ADCY4)
   04976 Bile secretion
    102286168 (ADCY4)
  09156 Nervous system
   04724 Glutamatergic synapse
    102286168 (ADCY4)
   04727 GABAergic synapse
    102286168 (ADCY4)
   04725 Cholinergic synapse
    102286168 (ADCY4)
   04723 Retrograde endocannabinoid signaling
    102286168 (ADCY4)
  09157 Sensory system
   04742 Taste transduction
    102286168 (ADCY4)
   04750 Inflammatory mediator regulation of TRP channels
    102286168 (ADCY4)
  09149 Aging
   04211 Longevity regulating pathway
    102286168 (ADCY4)
   04213 Longevity regulating pathway - multiple species
    102286168 (ADCY4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    102286168 (ADCY4)
   04714 Thermogenesis
    102286168 (ADCY4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102286168 (ADCY4)
  09165 Substance dependence
   05032 Morphine addiction
    102286168 (ADCY4)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy (DCM)
    102286168 (ADCY4)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    102286168 (ADCY4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102286168 (ADCY4)
   05163 Human cytomegalovirus infection
    102286168 (ADCY4)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    102286168 (ADCY4)
Enzymes [BR:bom01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     102286168 (ADCY4)
SSDB
Motif
Pfam: Guanylate_cyc DUF1053 AC_N CD52
Other DBs
NCBI-GeneID: 102286168
NCBI-ProteinID: XP_005910346
UniProt: L8HRR9
Position
Un
AA seq 1077 aa
MARLFSPRQPPSEDLFYETYYSLSQQYPLLLLLLLIVLLGLLALLPVAWASGRELAADPA
FLTTVLCALGGFSLLLVLASREQRLQRWTRPLSGLVWAALLALGHSFLFTGGVVSAWDQV
SFFLFVIFTVYAMLPLDMRDAITAGVTSSLSHLLVLGLYLGPQPDSRPALLPQLAANAVL
FLCGNAAGAYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMK
EEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE
LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATG
VDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEASGVPGRVHITGATLALLAG
AYAVEDAAMEHRDPYLRELGEPTYLVIDPWAAEEDEKGTAGGLLSSLEGSKMRPSLLMTR
YLESWGAAKPFAHLSHVESPVSTSTPLPEKALSSFSPQWSLDRSRTMRGPDEELDTGDAK
FFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSALPAFKYYAACTFLVFLSNFI
IQMLVTNRPPALTITYGITFLLFFLLLFVCFSEYLMKCVLKGPKMLHWLPTLSVLVATRP
GLRVALGTATILLVFVMAITSLVFLPATSACPFQAPNMSSMASNLSWELPGSLPLISIPY
SMHCCVLGFLSCSLFLHMSFELKLLLLLLWLTASCSIFLHSHAWLSDCLIARLYLGTLDS
RPGVLKEPKLMGAVSFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEQEETETMENLTRL
LLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESSINHEGLECLR
LLNEIIADFDELLSKPKFSGVEKIKTICSTYMAATGLNATSGQDAQQDAEQSCGHLGTMV
EFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMEST
GVLGKIQVTEETAWALQSLGYTCYSRGIIKVKGKGQLCTYFLNTDLTRTGPPSATLG
NT seq 3234 nt   +upstreamnt  +downstreamnt
atggcccgcctcttcagtccacggcagccccccagcgaagacctcttctacgagacctac
tacagcctgagccagcagtacccactgctgctgctgctgctgctgatcgtgctcttgggg
ctcctggcgctgctccctgtggcctgggcaagtggcagggagctggccgcagacccagcc
ttcctgaccactgtgctgtgcgctctgggtggcttctcactgctgctggtcctggcttcc
cgggagcagcgactgcagcgctggacgcgtcccctgtcaggcctcgtgtgggcagcactg
cttgcactaggccacagcttcctgttcactgggggcgtggtgagcgcctgggaccaggtg
tcctttttcctctttgtcatcttcactgtgtatgccatgttgcccctggacatgcgggac
gccatcaccgcgggtgtcacctcctcactctcacacttgctggtccttgggctgtatctt
gggcctcagcccgactctcggccggcgctgctgccacagctggctgcaaacgcggtgctg
ttcctgtgcgggaacgcggccggagcctatcacaaggcgctgatggagcgcgcgctgcgc
gccacgttccgggaggcgcttagttccctgcactcgcggcggagactggacaccgagaag
aagcatcaggaacaccttctcttgtccatccttcctgcctacctggcccgagagatgaag
gaggagatcatggcacggctgcaggctggacaggggtcacggccagagagcaccaacaac
ttccacagcctctatgtcaagaggcaccagggagtcagcgtgctgtatgctgacatcgtg
ggcttcacgagactggccagtgagtgctcccctaaggagttggtgcttatgctcaacgag
ctctttggcaagttcgaccaaatcgccaaggagcacgaatgcatgcggatcaagatccta
ggagactgttactactgtgtctccggcctgccgctctcactgcctgaccacgccatcaac
tgtgtgcgcatggggctggacatgtgccgggccatcaggaaacttcgggcagccacaggc
gtggatatcaacatgcgtgtgggcgtgcactcaggcagcgtgctctgcggggtcatcggg
ctacagaaatggcagtatgatgtctggtcccatgacgtcactctggccaaccacatggag
gcgagtggagtgccaggacgagtacatatcacaggggctacgctggccctgctggccggg
gcttatgctgtggaggatgcagccatggaacaccgggacccataccttcgggagctaggg
gagccgacctacctggtcatcgacccctgggctgcagaggaggacgagaagggtactgca
ggagggttgctgtcctctcttgagggctccaagatgcgtccatcactgctgatgacccgc
tacctggagtcctggggtgcagccaagcctttcgcccacctgagccacgtggagagccct
gtgtccacatctacccctctcccggagaaggccctgtcttccttcagcccccagtggagc
ctggaccggagccgtaccatgaggggacctgatgaggaactagacactggggatgccaag
ttcttccaggtcatcgaacagctcaattctcagaaacaatggaaacagtcgaaggacttc
aatccactgacactgtacttcagagagaaggagatggagaaagagtatcggctctctgca
ctccccgccttcaaatactatgcagcctgcaccttcctggtttttctctccaacttcatt
atccagatgctggtgacaaacaggcctccagctctgaccatcacctatggcatcaccttc
ctcctcttcttcctcctcctcttcgtctgcttctcagagtacctgatgaagtgtgtcttg
aaaggccccaagatgctgcactggctacccaccctgtctgtcctggtggccacacggcca
ggactgcgagtggctctgggcaccgctaccatcctgctcgtcttcgtcatggccattacc
agtctggtcttcttaccagcaacatcagcctgcccttttcaggctcccaatatgtcttcc
atggcttccaacctctcctgggagctccctgggtccctgcctctcatcagcatcccatac
tccatgcactgctgcgtgttgggcttcctctcctgctccctcttcctgcacatgagcttt
gagctgaagctgctgctgctcctgctgtggctgacggcctcctgctccatcttcctgcac
tcccacgcctggttgtccgactgcctcatcgcccgcctctacctgggcaccttggactcc
aggccaggggtgctgaaggagcccaaactgatgggagcagtctccttcttcatcttcttc
ttcaccctcctagtcctggctcggcagaatgaatattactgccgcctggactttctgtgg
aagaagaagctgaggcaagagcaggaggagacagagacaatggagaacctgactcggctg
ctcttggagaacgtgctccctgcgcacgtggccccccagttcattggtcagaatcggcgc
aatgaggacctctaccaccagtcctatgagtgtgtgtgtgtcctcttcgcctcggtccca
gacttcaaggagttctactctgaatccagcatcaaccatgaggggctagagtgtctgcgg
ctgctcaatgagataatcgctgattttgatgagctgctctccaagcccaagttcagtggg
gtggagaagatcaaaactatctgcagcacctacatggcagctaccggcttgaacgccacc
tctggacaggatgcacagcaggatgctgagcaaagctgcggccaccttggcaccatggta
gagtttgctgtggcccttgggtctaagctggatgtcatcaacaagcactcattcaacaac
tttcgcttgcgtgtagggttaaaccacggacctgtagtggctggagtgattggggcccag
aaaccacaatatgacatctggggcaacacggtgaatgtggccagccgcatggagagcaca
ggtgtcctgggcaagattcaggtaacagaagagacagcctgggccctccagtccttaggc
tacacctgctacagccggggcatcatcaaggtcaaaggcaaagggcagctctgcacctac
ttcttgaacacagatttgacacgaactggacctccctcagccaccctaggctga

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