KEGG   Bos taurus (cow): 281824
Entry
281824            CDS       T01008                                 
Symbol
HSD3B1
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
bta  Bos taurus (cow)
Pathway
bta00140  Steroid hormone biosynthesis
bta01100  Metabolic pathways
bta04913  Ovarian steroidogenesis
bta04925  Aldosterone synthesis and secretion
bta04927  Cortisol synthesis and secretion
bta04934  Cushing syndrome
Module
bta_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
bta_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
bta_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
bta_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:bta00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    281824 (HSD3B1)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    281824 (HSD3B1)
   04925 Aldosterone synthesis and secretion
    281824 (HSD3B1)
   04927 Cortisol synthesis and secretion
    281824 (HSD3B1)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    281824 (HSD3B1)
Enzymes [BR:bta01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     281824 (HSD3B1)
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     281824 (HSD3B1)
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 RmlD_sub_bind KR NmrA
Other DBs
NCBI-GeneID: 281824
NCBI-ProteinID: NP_776768
BGD-bta: BT11769
Ensembl: ENSBTAG00000006769
UniProt: P14893
Position
3:complement(23706726..23716623)
AA seq 373 aa
MAGWSCLVTGGGGFLGQRIICLLVEEKDLQEIRVLDKVFRPEVREEFSKLQSKIKLTLLE
GDILDEQCLKGACQGTSVVIHTASVIDVRNAVPRETIMNVNVKGTQLLLEACVQASVPVF
IHTSTIEVAGPNSYREIIQDGREEEHHESAWSSPYPYSKKLAEKAVLGANGWALKNGGTL
YTCALRPMYIYGEGSPFLSAYMHGALNNNGILTNHCKFSRVNPVYVGNVAWAHILALRAL
RDPKKVPNIQGQFYYISDDTPHQSYDDLNYTLSKEWGFCLDSRMSLPISLQYWLAFLLEI
VSFLLSPIYKYNPCFNRHLVTLSNSVFTFSYKKAQRDLGYEPLYTWEEAKQKTKEWIGSL
VKQHKETLKTKIH
NT seq 1122 nt   +upstreamnt  +downstreamnt
atggcagggtggagctgcctcgtgaccggaggaggaggctttctgggccagaggatcatc
tgcctgttggtggaggagaaggatctgcaggaaatccgggtgctagacaaagtcttcaga
ccagaagttcgggaggaattttctaagctccagagcaagatcaagctgaccctgctggaa
ggagacattctggatgagcagtgcctgaagggggcctgccagggcacctcagtggtcatc
cacaccgcctctgtcattgacgtcaggaatgctgtcccgcgagagaccatcatgaacgtc
aatgtgaaaggtacccagctgctgttggaggcctgtgtccaggccagcgtaccggtcttt
atccacaccagcaccatagaagtggctgggcccaactcctacagggagatcatccaagac
ggccgtgaagaagagcatcatgaatcggcatggtcctctccatacccatacagcaagaag
cttgccgagaaggctgtgctgggagctaatgggtgggctctgaaaaatggtggcaccttg
tacacttgtgccctgaggcccatgtacatctacggggaggggagcccattcctttctgcc
tacatgcacggagccttgaataacaacggcatcctgaccaatcactgcaagttctcaaga
gtcaacccagtctatgttggcaatgtggcctgggcccacattctggccttgagggccctg
agggaccccaaaaaggtcccaaacatccaaggacagttctactacatctcagacgacacg
ccacaccaaagctacgatgacctcaattacactttgagcaaagaatggggcttctgcctg
gattcccggatgagccttcctatttctctgcagtactggcttgccttcctgctggaaata
gtgagcttcctgctcagtccaatttacaaatataacccttgcttcaaccgccacctagtg
actctttccaacagcgtgttcaccttctcctataagaaagctcagcgagatctggggtat
gagcccctctacacttgggaggaagccaagcagaaaaccaaggagtggattggctccctg
gtgaaacagcacaaagagaccctgaaaacaaagattcactga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (10)   
   KEGG PATHWAY (6)   
   KEGG MODULE (4)   
Chemical substance (19)   
   KEGG COMPOUND (19)   
Chemical reaction (10)   
   KEGG ENZYME (2)   
   KEGG REACTION (8)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   BGD-BTA (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (6)   
   RefSeq(nuc) (2)   
   GenBank (2)   
   EMBL (2)   
Protein domain (9)   
   Pfam (9)   
All databases (75)   

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