KEGG   Bos taurus (cow): 282001Help
Entry
282001            CDS       T01008                                 

Gene name
PRKCA
Definition
(RefSeq) protein kinase C alpha type
  KO
K02677  classical protein kinase C alpha type [EC:2.7.11.13]
Organism
bta  Bos taurus (cow)
Pathway
bta01521  EGFR tyrosine kinase inhibitor resistance
bta04010  MAPK signaling pathway
bta04012  ErbB signaling pathway
bta04014  Ras signaling pathway
bta04015  Rap1 signaling pathway
bta04020  Calcium signaling pathway
bta04066  HIF-1 signaling pathway
bta04070  Phosphatidylinositol signaling system
bta04071  Sphingolipid signaling pathway
bta04072  Phospholipase D signaling pathway
bta04150  mTOR signaling pathway
bta04151  PI3K-Akt signaling pathway
bta04261  Adrenergic signaling in cardiomyocytes
bta04270  Vascular smooth muscle contraction
bta04310  Wnt signaling pathway
bta04360  Axon guidance
bta04370  VEGF signaling pathway
bta04510  Focal adhesion
bta04540  Gap junction
bta04650  Natural killer cell mediated cytotoxicity
bta04664  Fc epsilon RI signaling pathway
bta04666  Fc gamma R-mediated phagocytosis
bta04670  Leukocyte transendothelial migration
bta04713  Circadian entrainment
bta04720  Long-term potentiation
bta04723  Retrograde endocannabinoid signaling
bta04724  Glutamatergic synapse
bta04725  Cholinergic synapse
bta04726  Serotonergic synapse
bta04727  GABAergic synapse
bta04728  Dopaminergic synapse
bta04730  Long-term depression
bta04750  Inflammatory mediator regulation of TRP channels
bta04911  Insulin secretion
bta04912  GnRH signaling pathway
bta04916  Melanogenesis
bta04918  Thyroid hormone synthesis
bta04919  Thyroid hormone signaling pathway
bta04921  Oxytocin signaling pathway
bta04925  Aldosterone synthesis and secretion
bta04926  Relaxin signaling pathway
bta04928  Parathyroid hormone synthesis, secretion and action
bta04929  GnRH secretion
bta04933  AGE-RAGE signaling pathway in diabetic complications
bta04935  Growth hormone synthesis, secretion and action
bta04960  Aldosterone-regulated sodium reabsorption
bta04961  Endocrine and other factor-regulated calcium reabsorption
bta04970  Salivary secretion
bta04971  Gastric acid secretion
bta04972  Pancreatic secretion
bta05031  Amphetamine addiction
bta05032  Morphine addiction
bta05143  African trypanosomiasis
bta05146  Amoebiasis
bta05161  Hepatitis B
bta05163  Human cytomegalovirus infection
bta05164  Influenza A
bta05170  Human immunodeficiency virus 1 infection
bta05200  Pathways in cancer
bta05205  Proteoglycans in cancer
bta05206  MicroRNAs in cancer
bta05214  Glioma
bta05223  Non-small cell lung cancer
bta05225  Hepatocellular carcinoma
bta05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:bta00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    282001 (PRKCA)
   04015 Rap1 signaling pathway
    282001 (PRKCA)
   04010 MAPK signaling pathway
    282001 (PRKCA)
   04012 ErbB signaling pathway
    282001 (PRKCA)
   04310 Wnt signaling pathway
    282001 (PRKCA)
   04370 VEGF signaling pathway
    282001 (PRKCA)
   04066 HIF-1 signaling pathway
    282001 (PRKCA)
   04020 Calcium signaling pathway
    282001 (PRKCA)
   04070 Phosphatidylinositol signaling system
    282001 (PRKCA)
   04072 Phospholipase D signaling pathway
    282001 (PRKCA)
   04071 Sphingolipid signaling pathway
    282001 (PRKCA)
   04151 PI3K-Akt signaling pathway
    282001 (PRKCA)
   04150 mTOR signaling pathway
    282001 (PRKCA)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    282001 (PRKCA)
   04540 Gap junction
    282001 (PRKCA)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    282001 (PRKCA)
   04664 Fc epsilon RI signaling pathway
    282001 (PRKCA)
   04666 Fc gamma R-mediated phagocytosis
    282001 (PRKCA)
   04670 Leukocyte transendothelial migration
    282001 (PRKCA)
  09152 Endocrine system
   04911 Insulin secretion
    282001 (PRKCA)
   04929 GnRH secretion
    282001 (PRKCA)
   04912 GnRH signaling pathway
    282001 (PRKCA)
   04921 Oxytocin signaling pathway
    282001 (PRKCA)
   04926 Relaxin signaling pathway
    282001 (PRKCA)
   04935 Growth hormone synthesis, secretion and action
    282001 (PRKCA)
   04918 Thyroid hormone synthesis
    282001 (PRKCA)
   04919 Thyroid hormone signaling pathway
    282001 (PRKCA)
   04928 Parathyroid hormone synthesis, secretion and action
    282001 (PRKCA)
   04916 Melanogenesis
    282001 (PRKCA)
   04925 Aldosterone synthesis and secretion
    282001 (PRKCA)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    282001 (PRKCA)
   04270 Vascular smooth muscle contraction
    282001 (PRKCA)
  09154 Digestive system
   04970 Salivary secretion
    282001 (PRKCA)
   04971 Gastric acid secretion
    282001 (PRKCA)
   04972 Pancreatic secretion
    282001 (PRKCA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    282001 (PRKCA)
   04961 Endocrine and other factor-regulated calcium reabsorption
    282001 (PRKCA)
  09156 Nervous system
   04724 Glutamatergic synapse
    282001 (PRKCA)
   04727 GABAergic synapse
    282001 (PRKCA)
   04725 Cholinergic synapse
    282001 (PRKCA)
   04728 Dopaminergic synapse
    282001 (PRKCA)
   04726 Serotonergic synapse
    282001 (PRKCA)
   04720 Long-term potentiation
    282001 (PRKCA)
   04730 Long-term depression
    282001 (PRKCA)
   04723 Retrograde endocannabinoid signaling
    282001 (PRKCA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    282001 (PRKCA)
  09158 Development and regeneration
   04360 Axon guidance
    282001 (PRKCA)
  09159 Environmental adaptation
   04713 Circadian entrainment
    282001 (PRKCA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    282001 (PRKCA)
   05206 MicroRNAs in cancer
    282001 (PRKCA)
   05205 Proteoglycans in cancer
    282001 (PRKCA)
   05231 Choline metabolism in cancer
    282001 (PRKCA)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    282001 (PRKCA)
   05214 Glioma
    282001 (PRKCA)
   05223 Non-small cell lung cancer
    282001 (PRKCA)
  09165 Substance dependence
   05031 Amphetamine addiction
    282001 (PRKCA)
   05032 Morphine addiction
    282001 (PRKCA)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    282001 (PRKCA)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    282001 (PRKCA)
   05164 Influenza A
    282001 (PRKCA)
   05161 Hepatitis B
    282001 (PRKCA)
   05163 Human cytomegalovirus infection
    282001 (PRKCA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    282001 (PRKCA)
   05143 African trypanosomiasis
    282001 (PRKCA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    282001 (PRKCA)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bta01001]
    282001 (PRKCA)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bta04131]
    282001 (PRKCA)
Enzymes [BR:bta01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     282001 (PRKCA)
Protein kinases [BR:bta01001]
 Serine/threonine kinases: AGC group
  PKC family [OT]
   282001 (PRKCA)
Membrane trafficking [BR:bta04131]
 Endocytosis
  Lipid raft mediated endocytosis
   Caveolin-mediated endocytosis
    282001 (PRKCA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr C1_1 C2 Pkinase_C C1_2 Haspin_kinase APH Kinase-like
Motif
Other DBs
NCBI-GeneID: 282001
NCBI-ProteinID: NP_776860
BGD-bta: BT10523
Ensembl: ENSBTAG00000001061
VGNC: 33327
UniProt: P04409
Position
19
AA seq 672 aa AA seqDB search
MADVFPAAEPAAPQDVANRFARKGALRQKNVHEVKNHRFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPRWDESFTFKLKPSDKDRRL
SEEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVE
LRQKFEKAKLGPAGNKVISPSEDRRQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPGKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV
NT seq 2019 nt NT seq  +upstreamnt  +downstreamnt
atggctgacgtcttcccggccgccgagccggcggcgccgcaggacgtggccaaccgcttc
gcccgcaaaggggcgctgaggcagaagaacgtgcacgaggtgaagaaccaccgcttcatc
gcgcgcttcttcaagcagcccaccttctgcagccactgcaccgacttcatctgggggttt
gggaaacaaggcttccagtgccaagtttgctgttttgtggttcacaagaggtgccatgaa
tttgttactttttcttgtccgggggcggataaaggacccgacacagatgacccgaggagc
aagcacaagttcaagatccacacgtatggcagccccaccttctgtgatcactgcggctcc
ctgctctacggactcatccaccaggggatgaaatgtgacacctgtgatatgaacgtgcac
aagcagtgcgtgatcaacgtgcccagcctctgcgggatggaccacacggagaagaggggc
cgcatctacctgaaggccgaggtcacggatgaaaagctgcacgtcacagtacgagacgcg
aaaaacctaatccctatggatccaaatgggctttcagatccttacgtgaagctgaagctt
attcctgaccccaagaacgagagcaaacagaaaaccaagaccatccgctcgacgctgaac
ccccggtgggacgagtccttcacgttcaaattaaaaccttctgataaagaccggcgactg
tccgaggaaatctgggactgggatcgaaccacacggaacgacttcatggggtccctttcc
tttggggtctcggagctgatgaagatgccggccagcggatggtacaagctgctgaaccaa
gaggagggcgagtactacaacgtgccgatccccgaaggcgacgaggaaggcaatgtggag
ctcaggcagaaattcgagaaagccaagcttggccctgccggcaacaaagtcatcagtccc
tccgaggacaggagacagccttccaacaacctggacagagtgaagctcacggacttcaac
ttcctcatggtgctgggcaaaggcagctttgggaaggtgatgctggccgaccggaagggg
acagaggagctgtacgccatcaagatcctgaagaaggacgtggtcatccaggacgacgac
gtggagtgcaccatggtggagaagcgggtcctggcgctgctcgacaagccgccgttcctg
acgcagctgcactcctgcttccagacggtggaccggctgtacttcgtcatggagtacgtc
aacggcggggacctcatgtaccacatccagcaggtcgggaagttcaaggagccgcaagca
gtgttctatgcagcagagatttccatcgggctgttctttcttcataaaagaggaatcatt
tatcgggacctgaagttagacaacgtcatgctggactcggaaggacacattaagatcgcg
gacttcgggatgtgcaaggagcacatgatggacggcgtcacgaccaggaccttctgcggg
acccccgactacatcgccccagagataatcgcctatcagccgtacgggaagtccgtggac
tggtgggcctacggcgtcctgttgtacgagatgttggccgggcagcctccgttcgacggc
gaggacgaggacgagctgttccagtccatcatggagcacaacgtctcgtaccccaagtcc
ttgtccaaggaggccgtgtccatctgcaaagggctgatgaccaagcaccccgggaagcgg
ctgggctgcgggcccgagggcgagcgcgacgtgcgggagcatgccttcttccggaggatc
gactgggagaagctggagaaccgtgagatccagccacccttcaagcccaaagtgtgcggc
aaaggagcagagaactttgacaagttcttcacgcgagggcagcctgtcttgacgccgccc
gaccagctggtcatcgctaacatcgaccagtctgattttgaaggcttctcctacgtcaac
ccccagttcgtgcaccccatcctgcagagcgcggtatga

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