KEGG   Bos taurus (cow): 282041
Entry
282041            CDS       T01008                                 
Symbol
ROCK2
Name
(RefSeq) rho-associated protein kinase 2
  KO
K17388  Rho-associated protein kinase 2 [EC:2.7.11.1]
Organism
bta  Bos taurus (cow)
Pathway
bta04022  cGMP-PKG signaling pathway
bta04024  cAMP signaling pathway
bta04062  Chemokine signaling pathway
bta04071  Sphingolipid signaling pathway
bta04270  Vascular smooth muscle contraction
bta04310  Wnt signaling pathway
bta04360  Axon guidance
bta04510  Focal adhesion
bta04520  Adherens junction
bta04530  Tight junction
bta04611  Platelet activation
bta04670  Leukocyte transendothelial migration
bta04810  Regulation of actin cytoskeleton
bta04921  Oxytocin signaling pathway
bta05132  Salmonella infection
bta05135  Yersinia infection
bta05163  Human cytomegalovirus infection
bta05200  Pathways in cancer
bta05205  Proteoglycans in cancer
bta05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:bta00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    282041 (ROCK2)
   04071 Sphingolipid signaling pathway
    282041 (ROCK2)
   04024 cAMP signaling pathway
    282041 (ROCK2)
   04022 cGMP-PKG signaling pathway
    282041 (ROCK2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    282041 (ROCK2)
   04520 Adherens junction
    282041 (ROCK2)
   04530 Tight junction
    282041 (ROCK2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    282041 (ROCK2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    282041 (ROCK2)
   04670 Leukocyte transendothelial migration
    282041 (ROCK2)
   04062 Chemokine signaling pathway
    282041 (ROCK2)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    282041 (ROCK2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    282041 (ROCK2)
  09158 Development and regeneration
   04360 Axon guidance
    282041 (ROCK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    282041 (ROCK2)
   05205 Proteoglycans in cancer
    282041 (ROCK2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    282041 (ROCK2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    282041 (ROCK2)
   05135 Yersinia infection
    282041 (ROCK2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    282041 (ROCK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bta01001]
    282041 (ROCK2)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:bta03036]
    282041 (ROCK2)
Enzymes [BR:bta01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     282041 (ROCK2)
Protein kinases [BR:bta01001]
 Serine/threonine kinases: AGC group
  DMPK family [OT]
   282041 (ROCK2)
Chromosome and associated proteins [BR:bta03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    282041 (ROCK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Rho_Binding PH C1_1 Pkinase_C APH Irp3-like_C
Other DBs
NCBI-GeneID: 282041
NCBI-ProteinID: NP_776877
Ensembl: ENSBTAG00000005847
VGNC: 34082
UniProt: Q28021
Structure
Position
11:86489043..86617614
AA seq 1388 aa
MSRPPPTGKMPGAPEAVSGDGAGASRQRKLEALIRDPRSPINVESLLDGLNPLVLDLDFP
ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM
KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDKYLYMVMEYMPGGDLVNL
MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMD
ETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLV
GTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKNDQWN
WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENL
LLSDSPSCKENDSIQSRKNEESQEIQKKLYTLEEHLSTEIQAKEELEQKCKSVNTRLEKV
AKELEEEITLRKNVESTLRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL
EDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNR
DLQDKNCLLETAKLKLEKEFINLQSVLESERRDRTHGSEIINDLQGRISGLEEDVKNGKI
LLAKVELEKRQLQERFTDLEKEKNNMEIDMTYQLKVIQQSLEQEETEHKATKARLADKNK
IYESIEEAKSEAMKEMEKKLSEERTLKQKVENLLLEAEKRCSILDCDLKQSQQKINELLK
QKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLLEMKMS
LEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLCKELQQK
KQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQE
LTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKEAQEQLSRLKDEEISAAAIKAQF
EKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQ
MIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPG
DTEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVL
DIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKG
HEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYD
ISSAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSR
QLAPNKPS
NT seq 4167 nt   +upstreamnt  +downstreamnt
atgagccggcccccgccgacggggaagatgcccggcgcccccgaggccgtgtcgggggac
ggcgcgggcgcgagccgccagaggaagctggaagcgctgatccgagaccctcgttcgccc
atcaacgtggagagcttgctggatggcttaaatcctttggtccttgatttggattttcct
gctttgaggaaaaacaaaaatatagataatttcttaaatagatatgagaaaattgtgaaa
aaaattagaggtttacagatgaaggcagaagactacgatgttgtaaaagttatcggaaga
ggtgcttttggtgaagtccagttggttcgtcataaggcatcacagaaagtttatgctatg
aagcttcttagtaagtttgaaatgataaaaagatcagattctgcttttttctgggaggaa
agagatattatggcctttgccaacagtccctgggtggttcagctcttttgtgcctttcaa
gatgataagtatctgtacatggtaatggagtacatgcctggtggagaccttgtaaacctt
atgagtaactatgatgtacctgaaaaatgggccaaattttatactgctgaagttgttctt
gctttggatgccatacactccatgggtttaattcacagagatgtgaagcctgacaacatg
ctcttggataaacatgggcatctaaaattagcagattttggcacatgtatgaagatggat
gaaacaggcatggtgcattgtgatacagcagttggaacacccgattatatatcacccgag
gtcctgaaatcacaagggggtgatggttactatgggcgagaatgtgattggtggtccgtg
ggtgttttcctttttgaaatgctggtgggggatactccattttatgcagattcacttgta
ggaacatatagcaaaattatggatcataaaaactcactatgtttccctgaagatgcagaa
atttctaaacatgcgaagaatctcatctgtgccttcttaacagatagggaggtacgcctt
ggaagaaacggggtagaagaaatcaaacaacatcctttctttaagaatgatcagtggaat
tgggataacataagagagactgcagctcctgtggtacctgaactcagcagtgacatagac
agcagcaattttgatgacattgaagatgataaaggagatgtagaaaccttcccaattccc
aaggcttttgtgggaaatcagctaccttttataggatttacctactacagagaaaatttg
ctactaagtgactctccatcttgtaaagaaaatgactcaattcaatcaaggaagaatgaa
gagagtcaagagattcagaaaaaactgtacacattagaagaacaccttagcactgagatt
caggccaaagaggaactagaacagaagtgcaagtctgttaatactcgcttagagaaagtg
gcaaaggagttagaagaagagattaccttaaggaaaaatgtggaatcaacattaagacaa
ttagaaagagaaaaagcacttcttcagcacaaaaatgcagaatatcagcggaaagctgat
catgaagcagacaagaagcgaaatttggagaatgatgttaacagtttaaaagatcagctt
gaagatttgaaaaaaagaaatcagaactctcagatatccactgagaaagtgaatcaactc
cagagacaactggatgaaaccaatgctttgctgcgaacagaatctgatactgcagcccgg
ttaaggaaaacacaggcagaaagttcaaaacagattcagcagctggaatctaacaataga
gatctacaagacaaaaattgcctgctggagactgccaagttaaaacttgaaaaggaattt
atcaatcttcagtcagttctagaatctgaaaggagggaccgaacccatggatcagagatt
attaatgatttacaaggtagaatatctggcctagaagaagatgtaaagaatggtaaaatc
ttattagcaaaagtagagctggagaagagacaactacaggagagatttactgatttggaa
aaggaaaagaacaacatggaaatagatatgacataccaactaaaagtcatacagcaaagt
ttagaacaagaagaaactgaacataaggctacaaaagcacggcttgcagataaaaacaag
atttatgaatccattgaagaagctaaatcagaagccatgaaagaaatggagaaaaagctc
tcggaggaaagaactttaaaacagaaagtagagaacttgttgctggaggctgagaaaaga
tgctctatattagactgtgacctcaaacagtcacagcagaaaataaatgaactcctcaaa
cagaaagatgtgctaaatgaggatgttagaaacttgacattaaaaatagaacaggaaact
cagaagcgctgccttacacaaaatgacttgaagatgcaaacacagcaagttaacacacta
aaaatgtcagaaaagcagttaaagcaagagaataatcatctcctagaaatgaaaatgagc
ttggaaaaacagaatgctgaacttcgaaaagaacgtcaagatgcagatggacagatgaaa
gagctccaggatcagcttgaagcagagcagtatttctcaaccctctataaaacacaggtt
agggaacttaaggaagaatgtgaagaaaagaccaaactttgtaaagaattacagcagaag
aagcaggaattacaggatgaaagggactccttggctgctcaactggagattaccttaacc
aaagcagattctgagcaactggctcgttcaattgctgaggaacagtattctgatttggaa
aaagagaagatcatgaaagagctggagatcaaagagatgatggctcgacacaaacaggaa
ctcaccgaaaaagatgctactattgcgtctcttgaagaaactaataggacactaactagt
gatgttgccaatcttgcaaatgagaaagaagaattaaataacaaactgaaggaagcccaa
gagcaactatcaaggttgaaagatgaagaaataagtgcagcagctattaaagcacaattt
gagaagcagctgttaacagagaggacactcaaaactcaagctgtgaataagttggctgag
atcatgaatcgaaaggaacctgttaagcgtggtaatgacacagatgtgcggagaaaagaa
aaggagaatagaaagctacatatggaacttaaatctgaacgcgaaaaactgacccagcag
atgatcaagtatcagaaagaactgaatgaaatgcaggctcaaatagctgaagagagtcag
attcgaattgaactacagatgacactggacagtaaggacagtgacattgagcagctgcgc
tcccagctccaggccttgcacattggtttggatagttccagtataggcagtggaccaggg
gatactgaagctgatgacggttttccagaatcaagactagaaggatggctttcattgcct
gtgcgaaacaacactaagaaatttggatgggttaaaaagtatgtgattgtaagcagtaag
aagatccttttctatgacagtgagcaagataaagaacaatctaatccttacatggtttta
gatatagacaagttatttcatgtccgaccagttacacagacagatgtatatagagcagat
gctaaagaaattccaaggatattccagattctgtatgccaacgaaggagaaagtaagaag
gaacaagaatttccagtggagccagtgggagaaaaatcaaattatatttgccacaaggga
catgaatttattcctactctgtatcatttcccaaccaactgtgaggcatgtatgaagcca
ttgtggcacatgtttaaaccccctcctgctttagagtgccgtcgctgtcatattaaatgt
cataaagatcacatggacaaaaaggaggaaattatagcgccttgcaaagtgtattatgat
atttcatcggcaaagaatctattgttattggcaaattctacagaagagcagcaaaagtgg
gttagtcggttagtgaaaaaaatacctaaaaagcctccagctccagacccttttgcacgg
tcatctcctagaacgtcaatgaaaatacaacaaaaccagtctattcgacggccaagtcga
caacttgctccaaacaaaccaagctaa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (20)   
   KEGG PATHWAY (20)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (5)   
   RefSeq(nuc) (3)   
   GenBank (1)   
   EMBL (1)   
3D Structure (3)   
   PDB (3)   
Protein domain (8)   
   Pfam (8)   
All databases (65)   

Download RDF
DBGET integrated database retrieval system