KEGG   Bos taurus (cow): 504985
Entry
504985            CDS       T01008                                 
Symbol
TSC2
Name
(RefSeq) tuberin isoform X9
  KO
K07207  tuberous sclerosis 2
Organism
bta  Bos taurus (cow)
Pathway
bta04072  Phospholipase D signaling pathway
bta04115  p53 signaling pathway
bta04140  Autophagy - animal
bta04150  mTOR signaling pathway
bta04151  PI3K-Akt signaling pathway
bta04152  AMPK signaling pathway
bta04211  Longevity regulating pathway
bta04218  Cellular senescence
bta04714  Thermogenesis
bta04910  Insulin signaling pathway
bta04919  Thyroid hormone signaling pathway
bta05163  Human cytomegalovirus infection
bta05165  Human papillomavirus infection
bta05168  Herpes simplex virus 1 infection
bta05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:bta00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    504985 (TSC2)
   04151 PI3K-Akt signaling pathway
    504985 (TSC2)
   04152 AMPK signaling pathway
    504985 (TSC2)
   04150 mTOR signaling pathway
    504985 (TSC2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    504985 (TSC2)
  09143 Cell growth and death
   04115 p53 signaling pathway
    504985 (TSC2)
   04218 Cellular senescence
    504985 (TSC2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    504985 (TSC2)
   04919 Thyroid hormone signaling pathway
    504985 (TSC2)
  09149 Aging
   04211 Longevity regulating pathway
    504985 (TSC2)
  09159 Environmental adaptation
   04714 Thermogenesis
    504985 (TSC2)
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    504985 (TSC2)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    504985 (TSC2)
   05163 Human cytomegalovirus infection
    504985 (TSC2)
   05165 Human papillomavirus infection
    504985 (TSC2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:bta01009]
    504985 (TSC2)
Protein phosphatases and associated proteins [BR:bta01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     504985 (TSC2)
SSDB
Motif
Pfam: Tuberin DUF3384 Rap_GAP
Other DBs
NCBI-GeneID: 504985
NCBI-ProteinID: XP_010817500
Ensembl: ENSBTAG00000020617
VGNC: 36408
Position
25:1595321..1626208
AA seq 1814 aa
MAKPASKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSVECGLNNRIRV
IGQICEVARTKKFEEHAVEALWKAVSDLLQPERPPEARHAVLALLKAIVQGQGDRLGVLR
ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
VNLVKFNSCYLDEYIASMVHMVCLLCVQTVSSVDIEVSLQVLDAVVCYNCLPAESLPLFI
VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYHMCRIMEDRAYMEDAPLLRGAVFFVG
MALWGAHRLYSLKNSPTSVLPSFYEAMTCPNEVVSYEIVLSITRLIKKYRRELQAVTWDI
LLNIIERLLQQLQSLDSPELSAIVHDLLSTVEELCDQNEFHGSQERYFELVERCADQRPE
SSLLNLITYRAQSIHPAKDGWIHNLQLLMERFFRNESRSAVRIKVLDVLSFVLLINRQFY
EEELINSVVISQLSHIPEDRDHQVRKLATQLLVDLAEGCHTHHFNSLLDIVEKVIARSLS
PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYALPASHATRVYETLVSHIQLHYRH
SYTLPIASSIRLQAFDFLLQLRADSLHRLGLPSKDGLVRFSPYCVCDCLETERSSEKKAG
CPLSPPAGPPGPAPAGPAVRLGSLPYSLLFRVLLQCLKQETDWKVLKLVLSKLPESLRYK
VLIFTSPCSVDQLSAALCSMLSGPKTLERLRGTPEGFSRTDLHLAVVPVLTALISYHNYL
DKTRQREMVYCLEQGLIYRCASQCVVALAVCSVEMPDVILKALPVLVVKLTHISATASMA
IPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
RLPFRKDFVPYITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS
PPVKELKESSAADAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSMAQADDNLKNLHL
ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL
LGLDSGELQGGPELSSDPSMHVRQTKEAPAKLESQAGQQVYHGARDRVRSMSGGHGLRVG
ALDAPACYFPSSPTSPGSQTAPASQPEKASAGSPLPAQKEKTNLAAYVPLLTQGWAEILV
RRPTGNTSWLMSLENPLSPFSSDINSMPLQELSNALMAAERFKERRDTALYKSLSVPAAG
SAKPSPPPRSNTVASFSSLCQSRCQGKLHRSISWADSAVVLEEGGPGEAGLSAEPPELED
FEATLGSDGRCGRSDAFSRSSSTSSQEEKSFHAEELPPGGIPIERAVSEGSRASVDLAFQ
PSQPLSKSSSSPELQTLQDILGDPGDKAEVGRLSPEAKARSQSGILDGEGAAWSAPGEER
RGRGPAQPEGPLPSSCPRSPSGLRPRGYTISDSAPSRRGKRVERDAFKNRAGTSNTEKVP
GINPSFVFLQLYHSPFFGDESNKPILLPNESFERSVQLLDQIPSYDTHKIAVLYVGEGQS
NSELAILSNEHGSYRYTEFLTGLGKLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIM
QAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIITP
LDYECNLVSLQCRKDMEGLVDTSMAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDI
YPSKWIARLRHIKRLRQRIREEAHYSSASLPLMQTHPPGHAKAPAQAPAESTPTYETGQR
KRLVSSVDDFTEFV
NT seq 5445 nt   +upstreamnt  +downstreamnt
atggctaagccagcaagcaaagattcaggcttgaaggagaagttcaagattcttttggga
ctggggactccacggccaaatcccaggtctgcagagggcaaacagactgagtttatcatc
accgcggaaatcctgagagagctgagtgttgaatgtggcctcaataatcgcatccgggtg
atagggcagatctgtgaggttgccagaacgaagaaattcgaagagcacgcggtggaagca
ctctggaaggccgtctcggacctgctgcagccagagcggccacccgaggcccggcatgcg
gtgctggctctgctgaaggccatcgtgcaggggcagggggaccgcctgggcgttctcagg
gccctcttcttcaaggtcatcaaggattatccctctaatgaagacctccacgagagactg
gaagttttcaaggccctcacagacaatgggagacacatcacctacttggaagaagagctg
gcggactttgtcctgcagtggatggacgttggcctgtcctccgaattcctcctggtgctc
gtgaacttagtcaaattcaacagctgttaccttgatgagtacatcgcatccatggtccac
atggtctgcctgctgtgtgtccagaccgtgtcctccgtggacatagaggtgtctctgcag
gtgctggatgctgtggtctgctacaactgtctgccagccgagagcctccccctattcatc
gtcactctctgccgcaccatcaacgtcaaggagctctgtgaaccttgctggaagctgatg
cgcaacctcctgggcacccacctgggccacagcgccatctaccacatgtgccgcatcatg
gaagacagagcctacatggaggacgcaccactgctgagaggagccgtgttctttgttggc
atggctctctggggtgcccaccggctctattctctcaagaactccccaacatctgtgttg
ccatcgttttatgaggccatgacctgtccgaatgaggtggtgtcctacgagattgtcctc
tccataaccagactcatcaagaagtacaggagggagctccaggccgtgacctgggacatc
ctgctgaacatcatcgagcgcctgctccagcagctccagagcctggacagcccagagctg
agcgccatcgtgcacgatctgctgagcacagtggaggagctgtgtgaccagaacgagttt
cacggctcccaggagagatactttgaactcgtggagaggtgtgcggaccagaggcctgag
tcatcccttttaaacttaataacctacagggctcagtccatccatccagcgaaggacggc
tggatccacaacctgcagctgctgatggagaggtttttcaggaacgagtcacgcagtgcc
gtgcgcatcaaggtgctggacgtcctgtccttcgtgctgctcatcaacaggcagttctac
gaggaggagcttatcaactcagtggtcatctcgcagctctcccacatccctgaggataga
gaccaccaggtccggaagctggccactcagctgctggtagatctggccgaaggctgccac
acccaccacttcaacagcctgctggacattgttgagaaggtgatcgcccgttccctctct
ccgccccccgagctggaggagagggatgtggccgcgtactcggcctccttggaggatgtg
aagactgcggtcctggggctcctggtcatccttcagactaagctgtatgccctgcctgcc
agccatgccacacgcgtgtacgagacgctggtcagccacattcagctccactacaggcac
agctacaccctgcccatcgccagcagcatccgtctgcaggccttcgacttcctgctgcag
ctgcgggccgactcactgcaccgcctgggcctgcccagcaaagacgggcttgtgaggttc
agcccctactgcgtctgtgactgcctggagacagagaggagctccgagaagaaggccggg
tgccccctgtccccgcccgccgggccccctggccctgcgcctgcgggccctgccgtgcgc
cttgggtccctgccctactccctgctcttccgtgttctgctgcagtgtctgaagcaggag
accgactggaaggtgctgaagctggtgctcagcaaactgcccgagtcgctgcgctataag
gtcctcatcttcacctccccatgcagtgtcgaccagctgtccgccgccctctgctccatg
ctttcaggtcccaagaccctggagcggctccgaggcactccagaaggcttctccagaacc
gacctgcatctcgctgtggttcccgtgctgacagccctgatctcttaccataactacttg
gacaaaactagacagcgggagatggtgtactgcctggagcaaggcctcatctaccgctgt
gccagccagtgtgtggtggccctggccgtgtgcagcgtggagatgcccgacgtcatcctc
aaggcactgcccgtcctggttgtgaagctcacacacatctcggccacggccagcatggcc
atcccgctcctcgagttcctgtccactctggccagactgcctcacctctacaggaacttc
gcagcagagcagtatgccagtgtgtttgccatctccctgccgtataccaacccctccaag
ttcaatcagtacatcgtgtgcctggcccatcacgtcatagccatgtggttcatcaggtgc
cgcctgcccttccggaaggactttgttccttacatcaccaagggtctgcgctccaacgtc
ctcctgtctttcgatgacacccccgagaaggacagcttccgagcgcggagcaccagtctc
aacgagaggcccaagagtttgaggatagccagaccccccaaacaaggcttgaataactct
ccacccgtgaaagaactcaaggagagctctgcagccgatgccttccggtgccgcagcatc
agtgtgtctgaacatgtggtccgcagcaggatccagacctctctcacgagcgccagcttg
gggtctgcagacgagaactcgatggcccaggccgacgacaacttgaaaaacctccacctg
gagctcacagagacgtgtctggacatgatggccagatatgtgttctccaacttcacggcg
gtccccaagaggtcccccgtgggagagttcctcctggctggtggcaggaccaaaacctgg
ctggttgggaacaagcttgtcaccgtgacgacaagcgtggggaccgggacccggtcactg
ctaggcctggactctggagagctgcagggtggcccggagttgagctctgaccccagcatg
catgtgagacagacaaaggaggcacccgccaagctggagtcccaagctgggcagcaggtg
taccacggagcccgggaccgggtccgctccatgtccgggggccatggccttcgcgtgggt
gccttggacgctccagcctgctacttccccagcagccccacgtccccgggctcccagacc
gctccagccagccagcccgagaaggcctcagctggcagcccgctcccagcacagaaggag
aagacaaacctggccgcttacgtgcccctgctgacccagggctgggcagagatcctggtc
cgcaggcccacagggaacaccagctggctgatgagcctggagaacccgctcagccccttc
tcctcggacatcaacagcatgccgctgcaggagctgtccaatgccctcatggccgccgag
cgcttcaaggagcgccgcgacacagccctgtacaagtcgctgtcggtgccggcggccggc
tcagccaagccatccccgcccccacgctccaacacagtggcctctttctcctccctgtgc
cagtccaggtgccaaggaaagctgcacaggagcatttcctgggcagattctgcggtggtc
ctggaggagggaggtccaggtgaggctggtttgtctgcagagcctcccgagttggaagat
tttgaggcgacactgggctccgacgggcgctgtgggcgcagcgacgctttcagcaggtca
tcttccacctccagccaggaggagaagtcattccatgccgaggagttgcctcctgggggc
atccccatcgagcgggcggtctcggagggctcccgggcctccgtggacctcgccttccag
ccctctcagcccctgagcaagtccagctcgtcgcctgaactgcagaccctgcaggacatc
ctgggggaccccggggacaaggctgaggttggccggctgagccccgaggccaaggcccgg
tcgcagtcagggatcctggacggggaaggtgccgcctggtcagccccgggtgaggaacgc
cggggtcggggccctgcccagccagagggccccctgccttccagctgtcctcgctccccc
agcgggctgcggccccgaggctacaccatctcggattcggccccgtcacgcaggggcaag
agggtggagagggatgccttcaagaaccgagcagggacctccaacaccgagaaggtgcca
ggcatcaaccccagcttcgtgttcctgcagctctaccactcaccgttctttggtgacgag
tccaacaagccaatccttttgcctaacgagtctttcgaacgatcagtgcagctccttgat
cagatcccgtcgtacgacacgcacaagatcgcggtcctgtacgtgggagaaggccagagc
aacagcgagctcgccatcctgtccaacgagcatggctcctacaggtacacagagttcctc
acggggctgggcaagctcatcgagctcaaggactgccagccggacaaggtgtacctgggc
ggcctggacgtgtgcggcgaggatggccagttcacctactgctggcacgacgacatcatg
caagctgtcttccacatcgccaccctgatgcccaccaaggacgtggacaagcaccgctgt
gacaagaagcgccacctgggcaacgacttcgtgtccatcgtctacaacgactctggcgag
gacttcaagttgggcaccatcaagggccaattcaacttcgtccacgtgattatcacgccc
ctggactacgagtgcaacctggtgtctctgcagtgcaggaaagacatggagggccttgtg
gataccagcatggccaagatcgtgtctgaccgaaacctgcccttcgtggcccgccagatg
gccctgcacgccaatatggcctcgcaggtgcaccatagccgctccaatcccaccgacatt
tatccctccaagtggattgccaggctccgccacatcaagcggctgcgccagcggatccgt
gaggaagcccactactcaagcgccagcctgcccctgatgcagacacaccctcctggtcat
gccaaggctccggcacaggccccggccgagtccacgcccacctatgagacgggccagcgg
aaacgcctggtctcctctgtggacgacttcactgagttcgtgtga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (15)   
   KEGG PATHWAY (15)   
Genome (1)   
   KEGG GENOME (1)   
Gene (38)   
   KEGG ORTHOLOGY (1)   
   RefGene (32)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (23)   
   RefSeq(pep) (23)   
DNA sequence (23)   
   RefSeq(nuc) (23)   
Protein domain (3)   
   Pfam (3)   
All databases (105)   

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