KEGG   Bos taurus (cow): 536051
Entry
536051            CDS       T01008                                 
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X9
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
bta  Bos taurus (cow)
Pathway
bta01521  EGFR tyrosine kinase inhibitor resistance
bta01522  Endocrine resistance
bta04010  MAPK signaling pathway
bta04012  ErbB signaling pathway
bta04015  Rap1 signaling pathway
bta04024  cAMP signaling pathway
bta04062  Chemokine signaling pathway
bta04068  FoxO signaling pathway
bta04150  mTOR signaling pathway
bta04270  Vascular smooth muscle contraction
bta04510  Focal adhesion
bta04650  Natural killer cell mediated cytotoxicity
bta04720  Long-term potentiation
bta04722  Neurotrophin signaling pathway
bta04726  Serotonergic synapse
bta04730  Long-term depression
bta04810  Regulation of actin cytoskeleton
bta04910  Insulin signaling pathway
bta04914  Progesterone-mediated oocyte maturation
bta04928  Parathyroid hormone synthesis, secretion and action
bta04934  Cushing syndrome
bta05010  Alzheimer disease
bta05022  Pathways of neurodegeneration - multiple diseases
bta05034  Alcoholism
bta05160  Hepatitis C
bta05161  Hepatitis B
bta05200  Pathways in cancer
bta05205  Proteoglycans in cancer
bta05208  Chemical carcinogenesis - reactive oxygen species
bta05210  Colorectal cancer
bta05211  Renal cell carcinoma
bta05212  Pancreatic cancer
bta05213  Endometrial cancer
bta05214  Glioma
bta05215  Prostate cancer
bta05216  Thyroid cancer
bta05218  Melanoma
bta05219  Bladder cancer
bta05220  Chronic myeloid leukemia
bta05221  Acute myeloid leukemia
bta05223  Non-small cell lung cancer
bta05224  Breast cancer
bta05225  Hepatocellular carcinoma
bta05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:bta00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    536051 (BRAF)
   04012 ErbB signaling pathway
    536051 (BRAF)
   04015 Rap1 signaling pathway
    536051 (BRAF)
   04068 FoxO signaling pathway
    536051 (BRAF)
   04024 cAMP signaling pathway
    536051 (BRAF)
   04150 mTOR signaling pathway
    536051 (BRAF)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    536051 (BRAF)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    536051 (BRAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    536051 (BRAF)
   04062 Chemokine signaling pathway
    536051 (BRAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    536051 (BRAF)
   04914 Progesterone-mediated oocyte maturation
    536051 (BRAF)
   04928 Parathyroid hormone synthesis, secretion and action
    536051 (BRAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    536051 (BRAF)
  09156 Nervous system
   04726 Serotonergic synapse
    536051 (BRAF)
   04720 Long-term potentiation
    536051 (BRAF)
   04730 Long-term depression
    536051 (BRAF)
   04722 Neurotrophin signaling pathway
    536051 (BRAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    536051 (BRAF)
   05205 Proteoglycans in cancer
    536051 (BRAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    536051 (BRAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    536051 (BRAF)
   05212 Pancreatic cancer
    536051 (BRAF)
   05225 Hepatocellular carcinoma
    536051 (BRAF)
   05226 Gastric cancer
    536051 (BRAF)
   05214 Glioma
    536051 (BRAF)
   05216 Thyroid cancer
    536051 (BRAF)
   05221 Acute myeloid leukemia
    536051 (BRAF)
   05220 Chronic myeloid leukemia
    536051 (BRAF)
   05218 Melanoma
    536051 (BRAF)
   05211 Renal cell carcinoma
    536051 (BRAF)
   05219 Bladder cancer
    536051 (BRAF)
   05215 Prostate cancer
    536051 (BRAF)
   05213 Endometrial cancer
    536051 (BRAF)
   05224 Breast cancer
    536051 (BRAF)
   05223 Non-small cell lung cancer
    536051 (BRAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    536051 (BRAF)
   05160 Hepatitis C
    536051 (BRAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    536051 (BRAF)
   05022 Pathways of neurodegeneration - multiple diseases
    536051 (BRAF)
  09165 Substance dependence
   05034 Alcoholism
    536051 (BRAF)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    536051 (BRAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    536051 (BRAF)
   01522 Endocrine resistance
    536051 (BRAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bta01001]
    536051 (BRAF)
Enzymes [BR:bta01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     536051 (BRAF)
Protein kinases [BR:bta01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   536051 (BRAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 C1_2 Pkinase_fungal Kdo
Other DBs
NCBI-GeneID: 536051
NCBI-ProteinID: XP_005205968
BGD-bta: BT25565
Ensembl: ENSBTAG00000021761
VGNC: 26551
UniProt: A0A3Q1M353
Position
4:complement(104016173..104194462)
AA seq 766 aa
MAALSGGGGGGGGGAEQGQALFNGDMEPEAGAAASSAADPAIPEEVWNIKQMIKLTQEHI
EALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASTDTVT
SSSSSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSL
KKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKT
FFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIP
QEEASLAETTLPCGSSPSAPPSDSIGPPILTSPSPSKSIPIPQPFRPADEDHRNQFGQRD
RSSSAPNVHINTIEPVNIDDLIRDQGFRSDGGSTTGLSATPPASLPGSLSNVKALQKSPG
PQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVA
VKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHL
HIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK
SRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINN
RDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL
PKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq 2301 nt   +upstreamnt  +downstreamnt
atggcggcgctgagtggcggcggcggcggcggcggcggtggcgcggagcagggccaggct
ctgttcaacggggacatggagcccgaggccggcgccgcggcctcttcggctgcggacccc
gccattcccgaggaggtgtggaatatcaaacaaatgattaagttgacacaggagcatata
gaggccctattggacaaatttggtggggagcataatccaccatcaatatatctggaggcc
tatgaagaatacaccagcaagctagatgccctccaacaaagagaacaacagttattggaa
tccctggggaatggaactgatttttctgtttctagctctgcatcaacggacaccgttaca
tcttcttcctcttctagcctttcagtgctgccttcatctctttcagtttttcaaaatccc
acagatgtgtcacggagcaaccccaagtcaccacaaaaacctatcgttagagtcttcctg
cccaataaacagaggacagtggtacctgcacggtgtggagtcacagtccgggacagcctg
aagaaggcactgatgatgagaggtctaatcccagagtgctgtgctgtttacagaattcag
gatggggagaagaaaccaattggctgggacactgatatttcctggcttactggagaggag
ttgcatgtagaagtgttggagaatgttccacttacaacacacaactttgtacggaaaact
tttttcaccttagcattttgtgacttctgtagaaagctgcttttccagggattccgctgt
caaacatgtggttataaatttcaccagcgttgtagtacagaggttccactgatgtgtgtt
aattatgaccaactagatttgctgtttgtctccaagttctttgaacaccacccaatacca
caggaggaggcctccttagcagagactacccttccatgtggctcatccccttctgcaccc
ccctccgattctattgggcccccaattctcaccagtccatctccttcaaaatccattcca
attccacagcctttccgaccagcagatgaagatcatcgaaatcagtttggacaacgagac
cggtcctcatcagctccaaatgtgcatataaacacaatagaacccgtcaatattgatgac
ttgattagagaccaagggtttcgtagtgatggaggatcaaccacaggtttatccgccaca
ccccctgcctcattacctggctcactctctaatgtgaaagcattgcagaaatctccagga
cctcagcgagaaagaaagtcctcttcatcctcagaagacaggaatcgaatgaaaacgctt
ggtagacgggattcaagtgacgattgggagattcctgatggacagatcacagtgggacaa
agaattggatcagggtcatttgggacagtctacaagggaaagtggcatggtgatgtggca
gtgaaaatgttgaatgtgacagcacccacacctcagcagttacaggccttcaaaaatgaa
gtaggagtactcaggaaaacgcgacatgtgaatatcctcctcttcatgggttattcaaca
aagccacaactggctattgttacccagtggtgtgagggctccagtttatatcatcatctc
cacatcattgagaccaaattcgagatgatcaaacttatagatattgcacggcagactgca
cagggcatggattacttacacgccaagtcaatcatccacagagacctcaagagtaataat
atttttcttcatgaagacctcacagtaaaaataggtgattttggtctagccacagtgaaa
tctcgatggagtgggtcccatcagtttgaacagttgtctggatccattttgtggatggca
ccagaagtaatcagaatgcaagataaaaacccatatagctttcagtcagatgtatatgca
tttgggattgttctgtatgaattgatgaccggacagttaccttattcaaatatcaacaac
agggaccagataatttttatggtgggacgaggatatctgtctccagatctcagtaaggta
cggagtaactgtccaaaagccatgaagagattaatggcagagtgcctaaaaaagaaaaga
gatgaaagaccactctttccccaaattctcgcctctattgagctgctggcccgctcattg
ccaaaaattcaccgcagtgcatcagaaccctccttgaatcgggctggcttccaaacagag
gattttagtctatatgcttgtgcttctccaaaaacacccattcaggcagggggatatgga
gaatttgcagccttcaagtag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (44)   
   KEGG PATHWAY (44)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   BGD-BTA (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (18)   
   UniProt (1)   
   RefSeq(pep) (17)   
DNA sequence (19)   
   RefSeq(nuc) (17)   
   GenBank (1)   
   EMBL (1)   
Protein domain (10)   
   Pfam (10)   
All databases (110)   

Download RDF
DBGET integrated database retrieval system