KEGG   Bos taurus (cow): 787696
Entry
787696            CDS       T01008                                 
Symbol
TOP2A
Name
(RefSeq) DNA topoisomerase 2-alpha isoform X1
  KO
K03164  DNA topoisomerase II [EC:5.6.2.2]
Organism
bta  Bos taurus (cow)
Pathway
bta01524  Platinum drug resistance
Brite
KEGG Orthology (KO) [BR:bta00001]
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    787696 (TOP2A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:bta03032]
    787696 (TOP2A)
   03036 Chromosome and associated proteins [BR:bta03036]
    787696 (TOP2A)
Enzymes [BR:bta01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.2  DNA topoisomerase (ATP-hydrolysing)
     787696 (TOP2A)
DNA replication proteins [BR:bta03032]
 Eukaryotic type
  DNA Topoisomerases
   787696 (TOP2A)
Chromosome and associated proteins [BR:bta03036]
 Eukaryotic type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    787696 (TOP2A)
  Centrosome formation proteins
   Centriole proteins
    787696 (TOP2A)
SSDB
Motif
Pfam: DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT HATPase_c Toprim
Other DBs
NCBI-GeneID: 787696
NCBI-ProteinID: XP_005220838
BGD-bta: BT11705
Ensembl: ENSBTAG00000019262
VGNC: 49583
UniProt: F1MDU7
Position
19:complement(40627035..40653291)
AA seq 1532 aa
MEVSPLQPVNENMQVSKTKKNEDAKKRLSIERIYQKKTQLEHILLRPDTYIGSVESVTQQ
MWVYDEDIGINYREVTYVPGLYKIFDEILVNAADNKQRDPKMSCIRITIDPENNLISIWN
NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVE
TASREYKKMFKQTWMDNMGKAGEMELKPFSGEDYTCITFHPDLSKFKMQSLDKDIVALMV
RRAYDIAGSTKDVKVYLNGNRLPVKGFRSYVDLYLKDKVDETGNPLKVIHEQVNHRWEVC
LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
WIFVNALIENPTFDSQTKENMTLQVKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
IQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQTDD
RKEWLTHFMEDRRQRKLLGLPDDYLYGQATTYLTYNDFINKELILFSNSDNERSIPSMVD
GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPAKDDHTLKFLYDDNQRVEPEW
YIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLMDGEEPLPMLPSYKNFKGTVE
ELAPNQYVISGEVAILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
HTDTTVKFVVKMTEEKLAEAERAGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
GYDSDPVKAWKEAQQKVPDEEENEESDSEKETEKSDSATDSGPTFNYLLDMPLWYLTKEK
KDELCKLRNEKEQELETLKRKSPSDLWKEDLAAFVEELEVVEAKEKQDEQIGLPGKGGKA
KGKKTQMVEILPSPSGKRVIPRVTEEMKAEAEKKIKKKIKSENTEGSPQEDGMEMESQKL
RLEKKQKREPVTKTKKQTTLPFKPIKKAKKRNPWSDSESDMSSNESNFDVPPREKESRRA
AAKTKFTMDLDSDEDFSDFDEDTQDDFVPSNASPPKIQTSPKHNNKELKPLKSASSVTEL
DADDAEDNAPPPPSSPAADFPAVTETINPVPKKNVTAKKTAAKSQSSTSTTGTKKRAAPK
KTKKDPDLDSDVSKKPNAPKTKTRRKRKASSSDDSDSNFEKLISKAVTSKKPKEESDDFH
LDLDSAVGSRAKSVRTKKPIKYLEESDEDDFF
NT seq 4599 nt   +upstreamnt  +downstreamnt
atggaggtgtcgccactacagcctgtaaatgaaaatatgcaagtcagcaaaacaaagaaa
aatgaagatgctaagaaaagattgtctattgaaagaatctatcaaaagaaaacacaactg
gaacatatcctgctccgcccagacacctacattggctctgtggaatcagtgacccagcaa
atgtgggtttatgatgaagatattggcattaactatagggaagtcacttatgttcctggt
ttgtacaaaatctttgatgagattctagtcaatgctgcagacaacaaacaaagggaccca
aaaatgtcttgtattagaatcacaattgacccggaaaacaatttaattagtatatggaat
aatggaaaaggtattcctgttgtcgaacacaaagttgagaagatgtatgtcccagctctt
atctttggacagctcctaacttctagcaactatgatgatgaagaaaagaaagtaacaggt
ggtcgaaatggctatggagccaaactgtgtaacatattcagtaccaaatttactgtggaa
acagcaagtagagaatacaagaaaatgttcaaacagacatggatggataacatggggaaa
gctggtgagatggaactcaagccctttagtggagaagattatacatgtattaccttccac
cctgatttgtccaagtttaaaatgcaaagcctagacaaagatattgttgcactgatggtt
agaagagcatatgatattgctggatccactaaagatgtcaaagtctatctcaatggaaat
aggcttccagtgaaaggattccgtagctatgtagatctgtatctgaaggataaggtagat
gaaactggcaatccattgaaagttatccatgaacaagtaaaccacaggtgggaagtatgt
ttaacaatgagtgaaaaaggctttcagcaaattagctttgtcaacagcattgctacttcc
aagggtggccgacatgttgattatgtagctgatcagattgtgactaaacttgttgatgtt
gtgaagaaaaagaacaagggtggtgttgcagtaaaagcacatcaggtaaaaaatcacatg
tggatttttgtgaatgccttaattgaaaacccaaccttcgactcccagacaaaagagaac
atgactttacaagtcaagagctttggatcaacatgccagctgagtgaaaaattcatcaaa
gctgcgattggctgtggtattgtagaaagtatactaaattgggtgaaatttaaggcccaa
atccagttaaacaagaagtgttctgctgtaaaacataacagaatcaaaggaattcccaaa
cttgatgatgccaatgatgcaggaggccgaaactctactgagtgtacacttatcctgaca
gagggagactcagctaaaactttggctgtttcaggccttggtgtggttgggagagacaag
tatggggttttccctcttagaggaaaaatcctcaatgttcgagaagcttctcataaacag
ataatggaaaatgctgaaattaacaatataattaagattgtgggtcttcagtacaagaaa
aactatgaagatgaagattcactgaagactctacgttatggaaagataatgattatgaca
gatcaggaccaagacggttcccatatcaaaggcttgctgattaattttatccatcacaac
tggccctctcttctgcgacatcgttttctggaggaatttatcactcccattgtaaaggtg
tctaaaaacaaacaagaaatggcattctatagccttcctgagtttgaagaatggaagagt
tctacaccaaatcataaaaaatggaaagtcaaatattacaaaggtttgggtaccagcaca
tcaaaggaagctaaagaatactttgcagatatgaaaagacatcgtatccaatttaaatat
tccggtcccgaagatgatgctgcaatcagcctggcctttagcaaaaagcagacagatgat
cgaaaggaatggttaactcatttcatggaagatagaagacaacgaaagttacttggcctt
cctgatgattatttgtatgggcaagctaccacatatctgacatacaatgacttcataaac
aaggaacttatcctgttttcaaattctgataatgaaaggtctatcccatctatggtggat
ggtttgaaaccaggtcagagaaaggttttgtttacatgtttcaaacggaatgacaagcga
gaggtgaaggttgcccagttagctgggtcagtagctgagatgtcctcttatcatcatggt
gagatgtcactaatgatgaccattatcaatttggctcagaactttgtgggcagcaataat
ctgaaccttttgcagcccattggtcagtttggtaccaggttgcatggtggcaaggactct
gctagtcctcgatacatcttcacaatgctcagccctttggctcggttgttatttccagca
aaagatgaccatacattaaagtttttatatgatgacaaccagcgtgttgagcctgaatgg
tatattcctattatacccatggtgttgataaatggcgctgaaggaattggtactgggtgg
tcctgcaaaatccccaactttgatgttcgtgaagttgtgaataacatcagacgtttgatg
gatggagaagaacctttgccaatgcttccaagttacaagaacttcaagggtaccgttgag
gagctggctccaaatcaatatgtgattagtggtgaagtggctattcttaattctacaacc
attgaaatctcagagcttcccatcagaacgtggacccagacgtataaggaacaggttctt
gagcccatgttgaatggcactgagaagacaccgcctctcataacagattatagggaatac
cacacagacaccactgtgaagtttgttgtgaagatgactgaagaaaagctggcggaggca
gagagagctggactacacaaagtcttcaaactccaaactagtctcacatgcaactctatg
gtcctctttgaccatgtaggctgtttaaagaaatatgacacagttttggatattctaaga
gacttctttgaactcaggcttaaatattatggattaagaaaagaatggcttctaggaatg
cttggtgctgaatctgctaaactgaataatcaggctcgctttatcttagagaaaatagat
ggcaaaataatcattgaaaataagcctaagaaagagttaattaaagttctgattcagaga
ggatatgattcggatcctgtgaaggcttggaaagaagcccagcaaaaggttccggatgaa
gaagaaaatgaagaaagtgacagtgaaaaggaaactgaaaagagtgactctgcaacagat
tctggacctaccttcaactaccttcttgacatgcctctttggtatctaaccaaggaaaag
aaagatgaactgtgcaaactaagaaatgaaaaagagcaagagctagaaacattgaagaga
aagagtccatcagatttgtggaaagaagacttggctgcttttgttgaagagctggaggtt
gttgaagcaaaggagaaacaagatgaacaaataggacttcctgggaaaggtgggaaagca
aaggggaaaaaaacacaaatggtagaaattttgccttctccaagtggaaaaagagtcatc
ccccgagtgactgaagaaatgaaagcagaggcagaaaagaaaattaaaaagaaaattaag
agtgaaaatactgaaggaagccctcaagaggatggaatggaaatggaaagccaaaaactg
agactggaaaagaaacagaaaagagagccagttaccaagacaaagaaacaaactacattg
ccatttaaaccaatcaagaaagcaaagaaaagaaacccctggtccgattcagaatcagat
atgagcagtaacgaaagtaattttgatgtccctccacgagaaaaagagtcacggagagca
gcagcaaaaaccaaattcacaatggatttggattcagatgaagatttttcagattttgat
gaagacactcaagatgattttgtcccatcaaatgctagtccacctaagatccaaacttcc
ccgaaacataataacaaagaactgaagccactgaagagtgcctcatcagtaacagagctt
gatgctgatgatgctgaggataatgcaccacctcctccaagctctcctgctgcagatttc
ccagctgtaactgaaaccataaaccctgttcctaaaaagaatgtgacagcaaagaagaca
gcagcaaaaagtcagtcttccacctccactacaggcaccaaaaaaagggctgcaccaaaa
aaaaccaaaaaggatccagacttggattctgatgtctctaaaaagcctaatgcccccaaa
accaagactcgccgcaaaaggaaggcgtcctcctctgatgattccgactctaattttgag
aaactgatctccaaagcagtcacaagcaagaaacccaaggaggaaagtgatgatttccat
ctggacttggactcagctgtgggttctcgggcaaaatctgtaagaacaaagaaacctata
aagtaccttgaagaatcagatgaagatgatttcttttaa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (35)   
   KEGG ORTHOLOGY (1)   
   RefGene (28)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   BGD-BTA (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (6)   
   Pfam (6)   
All databases (53)   

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