KEGG   Camelus dromedarius (Arabian camel): 105102432
Entry
105102432         CDS       T04642                                 

Gene name
ADCY4
Definition
(RefSeq) adenylate cyclase type 4 isoform X1
  KO
K08044  adenylate cyclase 4 [EC:4.6.1.1]
Organism
cdk  Camelus dromedarius (Arabian camel)
Pathway
cdk00230  Purine metabolism
cdk01100  Metabolic pathways
cdk01522  Endocrine resistance
cdk04015  Rap1 signaling pathway
cdk04020  Calcium signaling pathway
cdk04022  cGMP-PKG signaling pathway
cdk04024  cAMP signaling pathway
cdk04062  Chemokine signaling pathway
cdk04072  Phospholipase D signaling pathway
cdk04114  Oocyte meiosis
cdk04211  Longevity regulating pathway
cdk04213  Longevity regulating pathway - multiple species
cdk04261  Adrenergic signaling in cardiomyocytes
cdk04270  Vascular smooth muscle contraction
cdk04371  Apelin signaling pathway
cdk04540  Gap junction
cdk04611  Platelet activation
cdk04713  Circadian entrainment
cdk04714  Thermogenesis
cdk04723  Retrograde endocannabinoid signaling
cdk04724  Glutamatergic synapse
cdk04725  Cholinergic synapse
cdk04727  GABAergic synapse
cdk04742  Taste transduction
cdk04750  Inflammatory mediator regulation of TRP channels
cdk04911  Insulin secretion
cdk04912  GnRH signaling pathway
cdk04913  Ovarian steroidogenesis
cdk04914  Progesterone-mediated oocyte maturation
cdk04915  Estrogen signaling pathway
cdk04916  Melanogenesis
cdk04918  Thyroid hormone synthesis
cdk04921  Oxytocin signaling pathway
cdk04923  Regulation of lipolysis in adipocytes
cdk04925  Aldosterone synthesis and secretion
cdk04926  Relaxin signaling pathway
cdk04927  Cortisol synthesis and secretion
cdk04928  Parathyroid hormone synthesis, secretion and action
cdk04934  Cushing syndrome
cdk04935  Growth hormone synthesis, secretion and action
cdk04970  Salivary secretion
cdk04971  Gastric acid secretion
cdk04972  Pancreatic secretion
cdk04976  Bile secretion
cdk05032  Morphine addiction
cdk05163  Human cytomegalovirus infection
cdk05166  Human T-cell leukemia virus 1 infection
cdk05200  Pathways in cancer
cdk05414  Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:cdk00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    105102432 (ADCY4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    105102432 (ADCY4)
   04371 Apelin signaling pathway
    105102432 (ADCY4)
   04020 Calcium signaling pathway
    105102432 (ADCY4)
   04072 Phospholipase D signaling pathway
    105102432 (ADCY4)
   04024 cAMP signaling pathway
    105102432 (ADCY4)
   04022 cGMP-PKG signaling pathway
    105102432 (ADCY4)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    105102432 (ADCY4)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    105102432 (ADCY4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105102432 (ADCY4)
   04062 Chemokine signaling pathway
    105102432 (ADCY4)
  09152 Endocrine system
   04911 Insulin secretion
    105102432 (ADCY4)
   04923 Regulation of lipolysis in adipocytes
    105102432 (ADCY4)
   04912 GnRH signaling pathway
    105102432 (ADCY4)
   04913 Ovarian steroidogenesis
    105102432 (ADCY4)
   04915 Estrogen signaling pathway
    105102432 (ADCY4)
   04914 Progesterone-mediated oocyte maturation
    105102432 (ADCY4)
   04921 Oxytocin signaling pathway
    105102432 (ADCY4)
   04926 Relaxin signaling pathway
    105102432 (ADCY4)
   04935 Growth hormone synthesis, secretion and action
    105102432 (ADCY4)
   04918 Thyroid hormone synthesis
    105102432 (ADCY4)
   04928 Parathyroid hormone synthesis, secretion and action
    105102432 (ADCY4)
   04916 Melanogenesis
    105102432 (ADCY4)
   04925 Aldosterone synthesis and secretion
    105102432 (ADCY4)
   04927 Cortisol synthesis and secretion
    105102432 (ADCY4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    105102432 (ADCY4)
   04270 Vascular smooth muscle contraction
    105102432 (ADCY4)
  09154 Digestive system
   04970 Salivary secretion
    105102432 (ADCY4)
   04971 Gastric acid secretion
    105102432 (ADCY4)
   04972 Pancreatic secretion
    105102432 (ADCY4)
   04976 Bile secretion
    105102432 (ADCY4)
  09156 Nervous system
   04724 Glutamatergic synapse
    105102432 (ADCY4)
   04727 GABAergic synapse
    105102432 (ADCY4)
   04725 Cholinergic synapse
    105102432 (ADCY4)
   04723 Retrograde endocannabinoid signaling
    105102432 (ADCY4)
  09157 Sensory system
   04742 Taste transduction
    105102432 (ADCY4)
   04750 Inflammatory mediator regulation of TRP channels
    105102432 (ADCY4)
  09149 Aging
   04211 Longevity regulating pathway
    105102432 (ADCY4)
   04213 Longevity regulating pathway - multiple species
    105102432 (ADCY4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    105102432 (ADCY4)
   04714 Thermogenesis
    105102432 (ADCY4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105102432 (ADCY4)
  09165 Substance dependence
   05032 Morphine addiction
    105102432 (ADCY4)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy (DCM)
    105102432 (ADCY4)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    105102432 (ADCY4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105102432 (ADCY4)
   05163 Human cytomegalovirus infection
    105102432 (ADCY4)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    105102432 (ADCY4)
Enzymes [BR:cdk01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     105102432 (ADCY4)
SSDB
Motif
Pfam: Guanylate_cyc DUF1053 AC_N CD52
Other DBs
NCBI-GeneID: 105102432
NCBI-ProteinID: XP_010994099
Position
6
AA seq 1076 aa
MARLFSPRPSPSEDLFFAETYYILSQQYPLLLLLLVIVICGLLALLAVASASGRELASDP
GFLTTVLCALGGFSLLLGLASREQRLQRWTRPLSGLVWAALLALGHGLLFTGGVVSAWDQ
VSFFLFVIFTVYAMLPLDMREAAAAGLASSLSHLLALGLYLGPQPDSRPALLPQLAANAV
LFLCGNVAGAYHKALMERALRATFREALSSLHSRWRLDTEKKHQEHLLLSILPAYLAREM
KAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLN
ELFGKFDQIAKDHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAAT
GVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEASGVPGRVHITGATLALLA
GAYAVEDAAMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGPKMRPSLLMT
RYLESWGAAKPFAHLSHVESPVSTSTPLPERALSSFSPQWSLDRSRTPRGLDDELDTGDA
KFFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSALPAFKYYAACTFLVFLSNF
IIQMLVTNRPPALAITYSITFLLFFLLLFVCFSEHLTKCVLKGPKMLHWLPTLSVLVATQ
PGLRVALGTATILLVFAMAITSLVFLPAASNCPFRAPNVSSVAFNFSWELPGSLPLISVP
YSMHCCVLGLLSCSLFLHMSFELKLLLLLLWLVASCSVFLHSHAWLSDCLVARLYPGPLD
SRPGVLKEPKLMGAICFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTR
LLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECL
RLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDSQQDSERSCSHLGTM
VEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMES
TGVLGKIQVTEETAGALQSLGYTCYSRGIIKVKGKGQLCTYFLNTDLTRAGPPSSL
NT seq 3231 nt   +upstreamnt  +downstreamnt
atggcccgcctcttcagtccccggccgtcccccagcgaagacctcttcttcgctgagacc
tactacatcctgagccagcagtacccactgctgctactgctgctggtgatcgtgatctgc
gggctcctggctctactggctgtcgccagtgccagcggcagggagctggcctccgaccct
ggcttcctgaccactgtgctgtgcgcgctgggtggcttctcgctactgctgggcctggct
tcccgtgagcagcgactgcagcgctggacgcgtcccctgtccggccttgtgtgggcagcg
ctgctcgcgctaggtcacggcctcctgttcaccgggggcgtggtgagcgcctgggaccag
gtgtcctttttcctttttgtcatcttcacggtgtatgccatgttgcccttggacatgcgg
gaagccgccgccgcgggcctcgcctcctcactctcacatctgctggccctcgggctgtat
cttgggcctcagccggactcacggcccgcgctgctgccgcagctggcagcaaacgcggtg
ctgttcctgtgcgggaacgtggcgggagcgtaccacaaggcgctgatggagcgcgcactg
cgcgccacgttccgggaggcgcttagttctctgcactcacgttggcggctggacaccgag
aagaagcaccaggaacaccttctcttgtccatccttcctgcctacctggcacgagagatg
aaggcagagatcatggcacggctgcaggctggacaggggtcacggccagagagcaccaac
aacttccacagcctctatgtcaagaggcaccagggagtcagtgtgctgtatgctgacatc
gtgggcttcacacggctggccagtgagtgctcccctaaggaattggtgctcatgctcaac
gagctctttggcaagttcgaccagatcgccaaggaccatgaatgcatgaggatcaagatc
ctgggagactgttactactgtgtctctgggctgccgctctccctgccagaccacgcaatc
aattgtgtgcgcatggggctggatatgtgccgggccatcaggaaacttcgggcagccacc
ggcgtggatatcaacatgcgtgtgggtgtacactcgggcagcgtgctctgtggtgtcatc
ggactgcagaaatggcaatatgatgtctggtcccatgacgttacactggccaaccacatg
gaggcgagtggagtgccaggacgagtacatatcacaggggctacactggccctgctggca
ggggcttatgctgtggaggatgcagccatggaacaccgggacccataccttcgggagcta
ggggagcctacctacctggtcattgatccccgggccgaggaggaggatgagaagggcact
gctggagggttgctgtcctctctcgagggccccaagatgcgtccatcgctgctgatgacc
cgctacctggagtcctggggtgcagccaagccatttgcccatctgagccacgtagagagc
cctgtgtccacctccacccctctcccggagagggccctgtcttccttcagcccccagtgg
agcctggaccggagccgtaccccccggggactggatgatgaactggacactggggatgcc
aagttcttccaggtcatcgaacagctcaactctcagaaacagtggaaacagtcaaaggac
ttcaaccctctgacactgtacttcagagagaaggagatggagaaagagtatcggctctct
gcactccccgccttcaagtactatgcagcttgcaccttcctggtttttctctccaacttc
atcatccagatgctggtaacaaacaggcccccagctctggccatcacctatagcatcacc
ttcctcctcttcttcctcctcctcttcgtctgcttctcagagcacctgacgaagtgtgtc
ttgaaaggccccaagatgctgcactggctgcccacgctctctgtcctggtggccacacag
cccggactgcgagtcgccctgggcactgccacaatcctgctcgtctttgctatggccatt
accagcctggtcttcctaccggcagcatcgaactgccctttccgggctcccaatgtgtcc
tccgtggctttcaacttctcctgggagctccctgggtccctgcctctcatcagtgtccca
tactccatgcactgctgcgtgctggggctcctctcctgctccctcttcctgcacatgagc
ttcgaactgaagctgctgttgctcctgctgtggctggtggcctcctgctccgtcttcctg
cactcccacgcgtggctgtccgactgcctcgtcgcccgcctctatccgggccccttggac
tccaggccaggggtgctgaaggagcccaaactgatgggagcgatctgtttctttatcttc
ttcttcaccctcctcgtcctggctcggcagaatgagtattactgccgcctggacttcctg
tggaagaagaagctgaggcaggagcgggaggagacagagacgatggagaacctgactcgg
ctgctcttggagaatgtactccctgcgcacgtggccccccagttcattggccagaatcgg
cgcaatgaggacctctaccaccagtcctacgagtgtgtttgcgtcctcttcgcctcagtc
ccagactttaaggagttttactctgaatccaacatcaaccatgaggggctagagtgtctg
cggctgctcaatgagataattgctgattttgatgagctgctctccaagcccaagttcagt
ggagtagagaaaatcaaaaccatcggcagcacctacatggcagctacaggcttaaatgcc
acctctggacaggactcacagcaggattctgagcggagctgcagccaccttggcaccatg
gtggagtttgccgtggcccttggatctaagctggacgtcatcaacaagcactcattcaac
aacttccgcttgcgtgtggggttaaaccatggacctgtggtagccggagtgattggggcc
cagaagccacaatatgacatctggggcaacacagtgaacgtggccagccgcatggagagt
acaggtgtactgggaaagatccaagtgactgaagagacagctggggccctgcagtcctta
ggctatacctgctacagccggggcatcatcaaggtcaaaggcaaagggcagctctgcacc
tacttcctgaacacagatttgactcgagctggacctccctcgtcactctag

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