KEGG   Caenorhabditis elegans (nematode): CELE_T07A9.6
Entry
CELE_T07A9.6      CDS       T00019                                 

Gene name
daf-18
Definition
(RefSeq) Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
  KO
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Organism
cel  Caenorhabditis elegans (nematode)
Pathway
cel00562  Inositol phosphate metabolism
cel01100  Metabolic pathways
cel04068  FoxO signaling pathway
cel04070  Phosphatidylinositol signaling system
cel04140  Autophagy - animal
cel04150  mTOR signaling pathway
cel04212  Longevity regulating pathway - worm
cel04361  Axon regeneration
Brite
KEGG Orthology (KO) [BR:cel00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    CELE_T07A9.6 (daf-18)
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    CELE_T07A9.6 (daf-18)
   04070 Phosphatidylinositol signaling system
    CELE_T07A9.6 (daf-18)
   04150 mTOR signaling pathway
    CELE_T07A9.6 (daf-18)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    CELE_T07A9.6 (daf-18)
 09150 Organismal Systems
  09158 Development and regeneration
   04361 Axon regeneration
    CELE_T07A9.6 (daf-18)
  09149 Aging
   04212 Longevity regulating pathway - worm
    CELE_T07A9.6 (daf-18)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:cel01009]
    CELE_T07A9.6 (daf-18)
Enzymes [BR:cel01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     CELE_T07A9.6 (daf-18)
    3.1.3.48  protein-tyrosine-phosphatase
     CELE_T07A9.6 (daf-18)
    3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
     CELE_T07A9.6 (daf-18)
Protein phosphatases and associated proteins [BR:cel01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Phosphatase and Tensin homologs (PTEN)
    CELE_T07A9.6 (daf-18)
SSDB
Motif
Pfam: PTEN_C2 Y_phosphatase DSPc Y_phosphatase3 PTPlike_phytase
Other DBs
NCBI-GeneID: 176869
NCBI-ProteinID: NP_499926
WormBase: WBGene00000913
Ensembl: WBGene00000913
UniProt: G5EE01
Position
IV:complement(join(420426..420545,420598..420996,421564..422008,422060..422662,423135..424000,424643..424887,424938..425148))
AA seq 962 aa
MVTPPPDVPSTSTRSMARDLQENPNRQPGEPRVSEPYHNSIVERIRHIFRTAVSSNRCRT
EYQNIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRRHGKGNVKVFNLRGGYY
YDADNFDGNVICFDMTDHHPPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMI
CALLIYINFYPSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHKLRERELNYLPLRMQL
IGVYVERPPKTWGGGSKIKVEVGNGSTILFKPDPLIISKSNHQRERATWLNNCDTPNEFD
TGEQKYHGFVSKRAYCFMVPEDAPVFVEGDVRIDIREIGFLKKFSDGKIGHVWFNTMFAC
DGGLNGGHFEYVDKTQPYIGDDTSIGRKNGMRRNETPMRKIDPETGNEFESPWQIVNPPG
LEKHITEEQAMENYTNYGMIPPRYTISKILHEKHEKGIVKDDYNDRKLPMGDKSYTESGK
SGDIRGVGGPFEIPYKAEEHVLTFPVYEMDRALKSKDLNNGMKLHVVLRCVDTRDSKMME
KSEVFGNLAFHNESTRRLQALTQMNPKWRPEPCAFGSKGAEMHYPPSVRYSSNDGKYNGA
CSENLVSDFFEHRNIAVLNRYCRYFYKQRSTSRSRYPRKFRYCPLIKKHFYIPADTDDVD
ENGQPFFHSPEHYIKEQEKIDAEKAAKGIENTGPSTSGSSAPGTIKKTEASQSDKVKPAT
EDELPPARLPDNVRRFPVVGVDFENPEEESCEHKTVESIAGFEPLEHLFHESYHPNTAGN
MLRQDYHTDSEVKIAEQEAKAFVDQLLNGQGVLQEFMKQFKVPSDNSFADYVTGQAEVFK
AQIALLEQSEDFQRVQANAEEVDLEHTLGEAFERFGHVVEESNGSSKNPKALKTREQMVK
ETGKDTQKTRNHVLLHLEANHRVQIERRETCPELHPEDKIPRIAHFSENSFSDSNFDQAI
YL
NT seq 2889 nt   +upstreamnt  +downstreamnt
atggttactcctcctccagatgtgccaagcacatcgaccaggtcgatggctcgtgacctt
caagagaatccaaaccgacaacctggtgaaccacgtgtgtctgaaccgtatcacaattca
atcgtcgagcggattcgccatatttttcggacggctgtatcttccaatcgttgtcgcacc
gagtaccaaaatatcgacctagattgtgcatatatcacagaccgaatcatagctatcggt
tatccagcaacaggaatcgaagcgaatttccgtaactcaaaagttcaaactcaacaattt
ctgaccaggcggcacggaaagggcaacgtgaaggtgtttaacctgcgcggtggatactac
tacgatgcggataacttcgatggaaatgttatttgcttcgatatgactgatcatcatccg
ccgagtctcgaattaatggctccgttttgcagagaggctaaggaatggcttgaagcagac
gataaacatgtaatagctgtacactgtaaagctggaaaaggccgtaccggagtgatgata
tgtgctcttctcatctacatcaacttctatccgagcccacgacaaattctcgactactac
tcaataattcgtacaaaaaacaacaaaggtgtcacaattccatcacaacgacgctacatt
tactactaccataagcttcgtgaacgtgagctcaactatttaccattgagaatgcagttg
attggtgtctacgtggaacggcctccaaagacatggggtggtggttcaaagataaaagtg
gaggttggaaatggctcgacaattttatttaagccggatcctctcataatctccaaatca
aatcatcagcgagagcgtgcgacgtggctgaacaactgtgatacgcctaacgaattcgac
accggagagcaaaaatatcatggatttgtttccaagagagcatactgttttatggtgcca
gaagatgctccagtatttgtcgaaggagatgttcgtatagacattcgcgaaatcggattt
ctcaaaaagttttcggacgggaagattggtcatgtttggttcaatacaatgttcgcatgt
gatggaggactcaacggtggacatttcgagtacgtagacaaaactcagccgtacatcgga
gacgatacatcaatcggacggaaaaatggaatgcgaagaaatgaaacgccgatgcgaaaa
attgatccagaaactggaaatgaatttgagtctccgtggcaaatagtgaatcctcctgga
ctggaaaaacatattacggaggaacaagcaatggaaaattataccaattatggcatgatt
cctcctcgatacacgatcagcaagattcttcacgaaaagcatgaaaaaggtatcgtcaag
gatgactataatgatcgtaagctgccaatgggagacaaatcatacacggaatcaggaaaa
agtggagatattcgaggagtcggtggtccatttgagataccatataaagctgaggaacat
gttctcacatttccagtttatgaaatggatcgagcattgaagagtaaagatcttaacaac
ggaatgaaacttcacgttgttcttcgttgtgtagatactcgtgattcaaaaatgatggaa
aagagcgaagtgttcggcaatctggcattccataatgaatcgacacggaggcttcaagcg
ttgactcaaatgaatccaaaatggcgacctgaaccgtgtgcgttcggatccaaaggtgct
gaaatgcattaccctccgtcggttcgatattcaagcaatgatggaaagtataatggagcc
tgcagtgagaaccttgttagcgattttttcgagcacagaaatattgccgttcttaatcga
tattgccgatatttctacaagcaacgcagtacatctcgaagccgttatccaagaaaattc
agatactgtcctctgatcaagaaacatttctacattccagctgataccgatgatgttgat
gaaaatgggcaaccgttcttccactcaccagagcattacattaaagaacaggaaaaaata
gacgcagagaaagcagctaaaggaattgaaaatactggacccagtacttcaggatcaagt
gctcccggaactatcaagaaaacggaagcttcacaatccgacaaggtgaagccggcaact
gaagacgaacttcctcctgcgaggctaccggataatgtgcgaagatttccagtcgtcggc
gttgatttcgaaaatccggaagaagaatcgtgtgaacacaaaaccgtagagtcaatagct
ggttttgaaccactcgaacatctattccatgaatcataccatccaaatacggccggtaac
atgctgcgtcaggattatcacactgattcggaagtgaaaatagctgaacaagaggcaaaa
gccttcgttgaccagttgcttaatggacaaggtgtattacaagagtttatgaagcaattc
aaagtaccatcggacaattcctttgctgattatgtaaccggacaggccgaagtttttaaa
gcacagattgcgttactggagcagtcggaggattttcaacgagttcaagcgaatgcagag
gaagtcgatcttgaacacactcttggtgaagcgtttgagcgattcgggcacgttgtagaa
gaatcgaatggttcttctaaaaatccaaaagccctgaaaactcgagaacaaatggtgaaa
gaaactggcaaagacactcagaagacccgcaatcatgtgcttctacatttggaagctaat
catcgtgtgcaaatcgagcgtcgtgaaacgtgcccggagctacatccagaggataaaatc
ccaagaattgctcatttttccgaaaacagcttctcggattcgaattttgatcaagctatt
tatttgtaa

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