KEGG   Caenorhabditis elegans (nematode): CELE_T07A9.6
Entry
CELE_T07A9.6      CDS       T00019                                 

Gene name
daf-18
Definition
(RefSeq) Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
  KO
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Organism
cel  Caenorhabditis elegans (nematode)
Pathway
cel00562  Inositol phosphate metabolism
cel01100  Metabolic pathways
cel04068  FoxO signaling pathway
cel04070  Phosphatidylinositol signaling system
cel04140  Autophagy - animal
cel04150  mTOR signaling pathway
cel04212  Longevity regulating pathway - worm
cel04361  Axon regeneration
Brite
KEGG Orthology (KO) [BR:cel00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    CELE_T07A9.6 (daf-18)
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    CELE_T07A9.6 (daf-18)
   04070 Phosphatidylinositol signaling system
    CELE_T07A9.6 (daf-18)
   04150 mTOR signaling pathway
    CELE_T07A9.6 (daf-18)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    CELE_T07A9.6 (daf-18)
 09150 Organismal Systems
  09158 Development and regeneration
   04361 Axon regeneration
    CELE_T07A9.6 (daf-18)
  09149 Aging
   04212 Longevity regulating pathway - worm
    CELE_T07A9.6 (daf-18)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:cel01009]
    CELE_T07A9.6 (daf-18)
Enzymes [BR:cel01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     CELE_T07A9.6 (daf-18)
    3.1.3.48  protein-tyrosine-phosphatase
     CELE_T07A9.6 (daf-18)
    3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
     CELE_T07A9.6 (daf-18)
Protein phosphatases and associated proteins [BR:cel01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Phosphatase and Tensin homologs (PTEN)
    CELE_T07A9.6 (daf-18)
SSDB
Motif
Pfam: PTEN_C2 Y_phosphatase DSPc Y_phosphatase3 PTPlike_phytase
Other DBs
NCBI-GeneID: 176869
NCBI-ProteinID: NP_499926
WormBase: WBGene00000913
Ensembl: WBGene00000913
UniProt: G5EE01
Position
IV:complement(join(420426..420545,420598..420996,421564..422008,422060..422662,423135..424000,424643..424887,424938..425148))
AA seq 962 aa
MVTPPPDVPSTSTRSMARDLQENPNRQPGEPRVSEPYHNSIVERIRHIFRTAVSSNRCRT
EYQNIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRRHGKGNVKVFNLRGGYY
YDADNFDGNVICFDMTDHHPPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMI
CALLIYINFYPSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHKLRERELNYLPLRMQL
IGVYVERPPKTWGGGSKIKVEVGNGSTILFKPDPLIISKSNHQRERATWLNNCDTPNEFD
TGEQKYHGFVSKRAYCFMVPEDAPVFVEGDVRIDIREIGFLKKFSDGKIGHVWFNTMFAC
DGGLNGGHFEYVDKTQPYIGDDTSIGRKNGMRRNETPMRKIDPETGNEFESPWQIVNPPG
LEKHITEEQAMENYTNYGMIPPRYTISKILHEKHEKGIVKDDYNDRKLPMGDKSYTESGK
SGDIRGVGGPFEIPYKAEEHVLTFPVYEMDRALKSKDLNNGMKLHVVLRCVDTRDSKMME
KSEVFGNLAFHNESTRRLQALTQMNPKWRPEPCAFGSKGAEMHYPPSVRYSSNDGKYNGA
CSENLVSDFFEHRNIAVLNRYCRYFYKQRSTSRSRYPRKFRYCPLIKKHFYIPADTDDVD
ENGQPFFHSPEHYIKEQEKIDAEKAAKGIENTGPSTSGSSAPGTIKKTEASQSDKVKPAT
EDELPPARLPDNVRRFPVVGVDFENPEEESCEHKTVESIAGFEPLEHLFHESYHPNTAGN
MLRQDYHTDSEVKIAEQEAKAFVDQLLNGQGVLQEFMKQFKVPSDNSFADYVTGQAEVFK
AQIALLEQSEDFQRVQANAEEVDLEHTLGEAFERFGHVVEESNGSSKNPKALKTREQMVK
ETGKDTQKTRNHVLLHLEANHRVQIERRETCPELHPEDKIPRIAHFSENSFSDSNFDQAI
YL
NT seq 2889 nt   +upstreamnt  +downstreamnt
atggttactcctcctccagatgtgccaagcacatcgaccaggtcgatggctcgtgacctt
caagagaatccaaaccgacaacctggtgaaccacgtgtgtctgaaccgtatcacaattca
atcgtcgagcggattcgccatatttttcggacggctgtatcttccaatcgttgtcgcacc
gagtaccaaaatatcgacctagattgtgcatatatcacagaccgaatcatagctatcggt
tatccagcaacaggaatcgaagcgaatttccgtaactcaaaagttcaaactcaacaattt
ctgaccaggcggcacggaaagggcaacgtgaaggtgtttaacctgcgcggtggatactac
tacgatgcggataacttcgatggaaatgttatttgcttcgatatgactgatcatcatccg
ccgagtctcgaattaatggctccgttttgcagagaggctaaggaatggcttgaagcagac
gataaacatgtaatagctgtacactgtaaagctggaaaaggccgtaccggagtgatgata
tgtgctcttctcatctacatcaacttctatccgagcccacgacaaattctcgactactac
tcaataattcgtacaaaaaacaacaaaggtgtcacaattccatcacaacgacgctacatt
tactactaccataagcttcgtgaacgtgagctcaactatttaccattgagaatgcagttg
attggtgtctacgtggaacggcctccaaagacatggggtggtggttcaaagataaaagtg
gaggttggaaatggctcgacaattttatttaagccggatcctctcataatctccaaatca
aatcatcagcgagagcgtgcgacgtggctgaacaactgtgatacgcctaacgaattcgac
accggagagcaaaaatatcatggatttgtttccaagagagcatactgttttatggtgcca
gaagatgctccagtatttgtcgaaggagatgttcgtatagacattcgcgaaatcggattt
ctcaaaaagttttcggacgggaagattggtcatgtttggttcaatacaatgttcgcatgt
gatggaggactcaacggtggacatttcgagtacgtagacaaaactcagccgtacatcgga
gacgatacatcaatcggacggaaaaatggaatgcgaagaaatgaaacgccgatgcgaaaa
attgatccagaaactggaaatgaatttgagtctccgtggcaaatagtgaatcctcctgga
ctggaaaaacatattacggaggaacaagcaatggaaaattataccaattatggcatgatt
cctcctcgatacacgatcagcaagattcttcacgaaaagcatgaaaaaggtatcgtcaag
gatgactataatgatcgtaagctgccaatgggagacaaatcatacacggaatcaggaaaa
agtggagatattcgaggagtcggtggtccatttgagataccatataaagctgaggaacat
gttctcacatttccagtttatgaaatggatcgagcattgaagagtaaagatcttaacaac
ggaatgaaacttcacgttgttcttcgttgtgtagatactcgtgattcaaaaatgatggaa
aagagcgaagtgttcggcaatctggcattccataatgaatcgacacggaggcttcaagcg
ttgactcaaatgaatccaaaatggcgacctgaaccgtgtgcgttcggatccaaaggtgct
gaaatgcattaccctccgtcggttcgatattcaagcaatgatggaaagtataatggagcc
tgcagtgagaaccttgttagcgattttttcgagcacagaaatattgccgttcttaatcga
tattgccgatatttctacaagcaacgcagtacatctcgaagccgttatccaagaaaattc
agatactgtcctctgatcaagaaacatttctacattccagctgataccgatgatgttgat
gaaaatgggcaaccgttcttccactcaccagagcattacattaaagaacaggaaaaaata
gacgcagagaaagcagctaaaggaattgaaaatactggacccagtacttcaggatcaagt
gctcccggaactatcaagaaaacggaagcttcacaatccgacaaggtgaagccggcaact
gaagacgaacttcctcctgcgaggctaccggataatgtgcgaagatttccagtcgtcggc
gttgatttcgaaaatccggaagaagaatcgtgtgaacacaaaaccgtagagtcaatagct
ggttttgaaccactcgaacatctattccatgaatcataccatccaaatacggccggtaac
atgctgcgtcaggattatcacactgattcggaagtgaaaatagctgaacaagaggcaaaa
gccttcgttgaccagttgcttaatggacaaggtgtattacaagagtttatgaagcaattc
aaagtaccatcggacaattcctttgctgattatgtaaccggacaggccgaagtttttaaa
gcacagattgcgttactggagcagtcggaggattttcaacgagttcaagcgaatgcagag
gaagtcgatcttgaacacactcttggtgaagcgtttgagcgattcgggcacgttgtagaa
gaatcgaatggttcttctaaaaatccaaaagccctgaaaactcgagaacaaatggtgaaa
gaaactggcaaagacactcagaagacccgcaatcatgtgcttctacatttggaagctaat
catcgtgtgcaaatcgagcgtcgtgaaacgtgcccggagctacatccagaggataaaatc
ccaagaattgctcatttttccgaaaacagcttctcggattcgaattttgatcaagctatt
tatttgtaa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (5)   
   KEGG ENZYME (3)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (38)   
   KEGG ORTHOLOGY (1)   
   RefGene (32)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   WORMBASE (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (5)   
   Pfam (5)   
All databases (70)   

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