KEGG   Canis lupus familiaris (dog): 100856570
Entry
100856570         CDS       T01007                                 
Symbol
GART
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3
  KO
K11787  phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 2.1.2.2 6.3.3.1]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa00230  Purine metabolism
cfa00670  One carbon pool by folate
cfa01100  Metabolic pathways
cfa01523  Antifolate resistance
Module
cfa_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    100856570 (GART)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    100856570 (GART)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    100856570 (GART)
Enzymes [BR:cfa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.2  Hydroxymethyl-, formyl- and related transferases
    2.1.2.2  phosphoribosylglycinamide formyltransferase 1
     100856570 (GART)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.1  phosphoribosylformylglycinamidine cyclo-ligase
     100856570 (GART)
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.13  phosphoribosylamine---glycine ligase
     100856570 (GART)
SSDB
Motif
Pfam: GARS_A Formyl_trans_N AIRS_C GARS_N GARS_C AIRS ATP-grasp ATP-grasp_2 CPSase_L_D2 Dala_Dala_lig_C ATP-grasp_3 ATP-grasp_4 RimK
Other DBs
NCBI-GeneID: 100856570
NCBI-ProteinID: XP_003640123
Ensembl: ENSCAFG00000030829
UniProt: A0A8C0Z741 A0A8I3PRU8
Position
31:complement(28131286..28163328)
AA seq 1011 aa
MAARVLVIGSGGREHTLAWKLAQSSHVKHVLVAPGNAGTACLEKISNTAISISDHTALAQ
FCKDEKIEFVVVGPEAPLAAGIAGNLTSAGVRCFGPTAEAAQLESSKRFAKEFMDRHGIP
TARWKAFTKPEEACSFIMSADFPALVVKASGLAAGKGVIVAKSTEEACKAVQEIMQDKAF
GAAGETIVIEELLEGEEVSCLCFTDGRTVAPMPPAQDHKRLLEGDHGPNTGGMGAYCPAP
QVSKDLFLKIKNTILQRTVDGMQQEGMPYTGVLYAGIMLTKEGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTLDGLLCTSLPVWLDNRAAITVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFHAGTALKDGKVVTNGGRVLTVTAIQENLLLALEEAKKGLSAIKFEGAFYRKD
IGYRAIAFFQQQPRGLTYKESGVDIAAGNMLVQKIKPLAKATSRPGCDVDLGGFAGLFDL
KAAGFRDPLLACGTDGVGTKLKIAQQCDKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFS
CGKLDLDTTEAVVTGIARACRKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKL
PHLERITEGDVVIGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPT
RIYSHSLLPILRSGHVKAFAHITGGGLLENIPRVLPQKFGVDLDAQSWRIPRIFSWLQQE
GHLSEEEMARTFNCGVGAALVVSKDLTEQILKDIKQHKEEAWVIGKVVACPEGSPRVKVR
HLIETMQINGSVLGNGTLKNHFSVQPKKARVAVLISGTGSNLQALIDSTREPSSCAHIVV
VISNKAAVAGLDKAERAGIPTRVINHKLYKSRVEFDTAIDQVLEEYSTDIVCLAGFMRIL
SGPFVRKWDGKMLNIHPSLLPSFKGSNAHEQALEAGVTVTGCTVHFVAEDVDAGQIILQE
SVPVKRGDTVATLSERVKLAEHKIFPAALQLVASGAIRLGENGKIRWVTED
NT seq 3036 nt   +upstreamnt  +downstreamnt
atggcagcccgagtacttgtaatcggcagtggaggaagggagcataccctggcctggaaa
cttgcacagtctagtcatgtcaaacatgtgttggttgccccaggaaatgcaggcactgcc
tgcttggaaaagatttcaaataccgccatctccatcagtgaccacactgcccttgctcag
ttctgcaaagatgagaaaattgaattcgtggttgttggaccagaggcacctctggctgct
ggaatcgctgggaacctgacatctgcaggagtgcgatgctttggtcccactgcagaagca
gctcaattagagtccagcaagagatttgccaaagagtttatggaccgacatggaatccca
actgcacggtggaaagctttcaccaaacctgaagaggcctgcagctttataatgagtgca
gacttccctgctttggttgtaaaggccagtggtcttgcagctggaaaaggggtgattgtt
gccaagagcacagaagaggcctgcaaggctgtacaggagattatgcaggataaagctttt
ggagcagctggagaaacaattgtcatcgaagaacttcttgaaggagaagaggtgtcttgt
ctgtgcttcactgatggaaggactgtggcccccatgcctccagcacaagaccataagcga
ttgctggaaggagatcatggccccaacacagggggaatgggggcctattgtccagcacct
caggtttctaaggatttgttcctgaaaataaaaaacaccattcttcagagaacagtggat
ggcatgcagcaggagggcatgccatacacaggtgttctctacgctggtataatgctgacc
aaggagggcccaaaagttctggagtttaattgccgttttggtgatccggagtgccaagtg
atcctcccacttcttaaaagtgatctttatgaagtgattcagtctaccttggatggcctg
ctctgcacatctctgcctgtttggcttgataaccgtgctgccataactgtggtaatggca
agtaaaggctatccaggagattacaccaagggtgtggagataacagggtttcccgaggct
caagctttaggactggaggtattccatgcaggcactgccctgaaagatggcaaagtggtg
actaacgggggtagagtccttacggtaacagcaatccaggaaaatctcctcttggccctt
gaagaagcaaagaaaggactatctgctataaaatttgagggagccttttacaggaaggac
attggctatcgtgccatagccttcttccagcagcagcccaggggcctgacttacaaagaa
tctggggtagacattgcagctggaaatatgctggtccaaaaaattaaacctttagccaaa
gctacttccagaccaggctgtgatgttgatcttggaggttttgctggtctttttgatttg
aaagcagctggtttcagagatcctcttctggcatgtggaacagatggtgttggaactaaa
ctgaagattgcccagcagtgtgataaacatgatactattggtcaagatttggttgcaatg
tgtgtcaatgacattctagctcaaggggctgagccccttttcttcctcgattacttttcc
tgtggaaaacttgacctcgatacaactgaagcagttgtcactggaattgccagagcttgc
agaaaagctggatgtgctctccttggaggtgaaactgcagaaatgcctgacatgtatcct
ccgggagaatatgacctagctggttttgccgttggtgccatggagcgggatcagaaactt
cctcacctggaaagaatcaccgaaggggatgttgttattggaatagcttcatctggtctt
cacagcaatggatttagccttgtcaggaaaattgtagcaaaatcttccctccagtactcg
tctccagcacccgatggctgtggtgaccagaccttaggggacttacttctaactccaacc
cgaatctacagccattcgctgttacctatcctacgttcaggacatgtgaaggcctttgcc
catattactggtggaggattgctagaaaacatccccagagtccttcctcagaaatttggg
gtggatttagatgcccaaagctggaggatccccaggatcttttcatggctacagcaggaa
ggacacctctctgaagaagagatggcgagaacatttaactgtggagttggggctgccctc
gtggtatcaaaggatctgacggagcagattctgaaggatattaagcagcacaaggaagaa
gcctgggtgattggcaaagtggtggcatgtcctgaaggttctcctcgtgtgaaagtcagg
catctgatagaaactatgcaaataaatgggtcagtattggggaatggcaccctgaaaaat
catttctctgttcaaccaaaaaaggcaagagtggctgtcttaatatctggaacaggatca
aacctgcaagctcttatagacagtactagggagcccagtagctgtgcacacattgttgtt
gttatctccaacaaagctgcagtggctggtttagataaagcagaaagagctggaattccc
accagagtaatcaaccataaattatataaaagtcgtgtagaatttgacactgccattgac
caagtccttgaagagtattccacagacatagtctgtcttgcaggattcatgagaatttta
tctgggccctttgtcagaaaatgggatgggaagatgctcaacatccacccctccttgctc
ccttcttttaagggttcaaatgcccatgagcaagccctggaagctggggtcacagtcact
gggtgtactgtgcactttgtagctgaagatgtagatgctggacaaattattttacaagaa
tctgttccagtgaagagaggtgacactgttgcaactctgtcggaaagagtgaaattagca
gagcataaaatatttcccgcagccctccagctggtagccagtggagctataaggcttgga
gaaaatggcaagatccgttgggtcacagaggattga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (13)   
   KEGG COMPOUND (13)   
Chemical reaction (7)   
   KEGG ENZYME (3)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (7)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (12)   
   UniProt (2)   
   RefSeq(pep) (10)   
DNA sequence (10)   
   RefSeq(nuc) (10)   
Protein domain (13)   
   Pfam (13)   
All databases (70)   

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