KEGG   Canis lupus familiaris (dog): 403832
Entry
403832            CDS       T01007                                 
Symbol
PTEN
Name
(RefSeq) phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  KO
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa00562  Inositol phosphate metabolism
cfa01100  Metabolic pathways
cfa01521  EGFR tyrosine kinase inhibitor resistance
cfa04068  FoxO signaling pathway
cfa04070  Phosphatidylinositol signaling system
cfa04071  Sphingolipid signaling pathway
cfa04115  p53 signaling pathway
cfa04140  Autophagy - animal
cfa04150  mTOR signaling pathway
cfa04151  PI3K-Akt signaling pathway
cfa04218  Cellular senescence
cfa04510  Focal adhesion
cfa04931  Insulin resistance
cfa05165  Human papillomavirus infection
cfa05166  Human T-cell leukemia virus 1 infection
cfa05200  Pathways in cancer
cfa05206  MicroRNAs in cancer
cfa05208  Chemical carcinogenesis - reactive oxygen species
cfa05213  Endometrial cancer
cfa05214  Glioma
cfa05215  Prostate cancer
cfa05218  Melanoma
cfa05222  Small cell lung cancer
cfa05224  Breast cancer
cfa05225  Hepatocellular carcinoma
cfa05230  Central carbon metabolism in cancer
cfa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cfa05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    403832 (PTEN)
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    403832 (PTEN)
   04070 Phosphatidylinositol signaling system
    403832 (PTEN)
   04071 Sphingolipid signaling pathway
    403832 (PTEN)
   04151 PI3K-Akt signaling pathway
    403832 (PTEN)
   04150 mTOR signaling pathway
    403832 (PTEN)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    403832 (PTEN)
  09143 Cell growth and death
   04115 p53 signaling pathway
    403832 (PTEN)
   04218 Cellular senescence
    403832 (PTEN)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    403832 (PTEN)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    403832 (PTEN)
   05206 MicroRNAs in cancer
    403832 (PTEN)
   05208 Chemical carcinogenesis - reactive oxygen species
    403832 (PTEN)
   05230 Central carbon metabolism in cancer
    403832 (PTEN)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    403832 (PTEN)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    403832 (PTEN)
   05214 Glioma
    403832 (PTEN)
   05218 Melanoma
    403832 (PTEN)
   05215 Prostate cancer
    403832 (PTEN)
   05213 Endometrial cancer
    403832 (PTEN)
   05224 Breast cancer
    403832 (PTEN)
   05222 Small cell lung cancer
    403832 (PTEN)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    403832 (PTEN)
   05165 Human papillomavirus infection
    403832 (PTEN)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    403832 (PTEN)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    403832 (PTEN)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    403832 (PTEN)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:cfa01009]
    403832 (PTEN)
Enzymes [BR:cfa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     403832 (PTEN)
    3.1.3.48  protein-tyrosine-phosphatase
     403832 (PTEN)
    3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
     403832 (PTEN)
Protein phosphatases and associated proteins [BR:cfa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Phosphatase and Tensin homologs (PTEN)
    403832 (PTEN)
SSDB
Motif
Pfam: PTEN_C2 DSPc Y_phosphatase PTPlike_phytase Y_phosphatase3 DUF3256
Other DBs
NCBI-GeneID: 403832
NCBI-ProteinID: NP_001003192
Ensembl: ENSCAFG00000015670
VGNC: 45138
UniProt: P60483
Position
26:37711222..37730964
AA seq 403 aa
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK
HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA
AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY
LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY
FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS
SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
NT seq 1212 nt   +upstreamnt  +downstreamnt
atgacagccatcatcaaggagatcgtcagcagaaacaaaaggcgctaccaggaggatggg
ttcgacttggacttgacctatatttatcccaacattattgctatggggtttcctgcagaa
agacttgaaggcgtatacaggaacaatattgatgatgtagtaaggtttttggattcaaag
cataaaaaccattacaagatatacaatctgtgtgctgaaagacattatgataccgccaaa
tttaactgcagagttgcacagtatccttttgaagaccataatccaccacagctagaactt
atcaaacccttttgtgaagatcttgaccaatggctaagtgaagatgacaatcatgttgca
gcaattcactgtaaagctggaaagggacgaactggtgtaatgatttgtgcatatttatta
catcggggcaaatttctaaaggcacaagaggccctagatttctatggggaagtaaggacc
agagacaaaaagggagtaactattcccagtcagaggcgctatgtgtattattatagctac
ctgttaaagaatcatctggattatagaccagtggcactgttgtttcacaagatgatgttt
gaaactattccaatgttcagtggcggaacttgcaatcctcagtttgtggtctgccagcta
aaggtgaagatctattcctccaattcaggacccacacgacgggaagacaagttcatgtac
tttgagttccctcagccattgcctgtgtgcggtgacatcaaagtagagttcttccacaaa
cagaacaagatgctaaaaaaggacaaaatgtttcacttttgggtaaacacattcttcata
ccaggaccagaggaaacctcagaaaaagtagaaaatggaagtctatgtgatcaagaaatt
gatagtatttgcagtatagaacgtgcagataatgacaaggaatatctagtactcacttta
acaaaaaatgatctcgacaaagcaaataaagacaaggccaaccgatatttttctccaaat
tttaaggtgaagctgtacttcacaaaaactgtagaggagccatcaaacccggaggctagc
agttcaacttctgtgacgccagatgttagtgacaatgaacctgatcattatagatattct
gacaccactgactctgacccagagaatgaaccctttgatgaagatcagcacacacaaatc
acaaaagtctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (28)   
   KEGG PATHWAY (28)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (5)   
   KEGG ENZYME (3)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (6)   
   RefSeq(nuc) (4)   
   GenBank (1)   
   EMBL (1)   
Protein domain (6)   
   Pfam (6)   
All databases (73)   

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