KEGG   Canis lupus familiaris (dog): 403883
Entry
403883            CDS       T01007                                 
Symbol
ERBB2
Name
(RefSeq) receptor tyrosine-protein kinase erbB-2 precursor
  KO
K05083  receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa01521  EGFR tyrosine kinase inhibitor resistance
cfa01522  Endocrine resistance
cfa01524  Platinum drug resistance
cfa04010  MAPK signaling pathway
cfa04012  ErbB signaling pathway
cfa04020  Calcium signaling pathway
cfa04066  HIF-1 signaling pathway
cfa04151  PI3K-Akt signaling pathway
cfa04510  Focal adhesion
cfa04520  Adherens junction
cfa04530  Tight junction
cfa05200  Pathways in cancer
cfa05205  Proteoglycans in cancer
cfa05206  MicroRNAs in cancer
cfa05212  Pancreatic cancer
cfa05213  Endometrial cancer
cfa05215  Prostate cancer
cfa05219  Bladder cancer
cfa05223  Non-small cell lung cancer
cfa05224  Breast cancer
cfa05226  Gastric cancer
cfa05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    403883 (ERBB2)
   04012 ErbB signaling pathway
    403883 (ERBB2)
   04066 HIF-1 signaling pathway
    403883 (ERBB2)
   04020 Calcium signaling pathway
    403883 (ERBB2)
   04151 PI3K-Akt signaling pathway
    403883 (ERBB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    403883 (ERBB2)
   04520 Adherens junction
    403883 (ERBB2)
   04530 Tight junction
    403883 (ERBB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    403883 (ERBB2)
   05206 MicroRNAs in cancer
    403883 (ERBB2)
   05205 Proteoglycans in cancer
    403883 (ERBB2)
   05230 Central carbon metabolism in cancer
    403883 (ERBB2)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    403883 (ERBB2)
   05226 Gastric cancer
    403883 (ERBB2)
   05219 Bladder cancer
    403883 (ERBB2)
   05215 Prostate cancer
    403883 (ERBB2)
   05213 Endometrial cancer
    403883 (ERBB2)
   05224 Breast cancer
    403883 (ERBB2)
   05223 Non-small cell lung cancer
    403883 (ERBB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    403883 (ERBB2)
   01524 Platinum drug resistance
    403883 (ERBB2)
   01522 Endocrine resistance
    403883 (ERBB2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cfa01001]
    403883 (ERBB2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:cfa04147]
    403883 (ERBB2)
   04090 CD molecules [BR:cfa04090]
    403883 (ERBB2)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     403883 (ERBB2)
Protein kinases [BR:cfa01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   403883 (ERBB2)
Exosome [BR:cfa04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   403883 (ERBB2)
CD molecules [BR:cfa04090]
 Proteins
  403883 (ERBB2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 Haspin_kinase Kinase-like
Other DBs
NCBI-GeneID: 403883
NCBI-ProteinID: NP_001003217
Ensembl: ENSCAFG00000016351
VGNC: 40436
Position
9:complement(22233500..22257730)
AA seq 1260 aa
MELAAWCRWGLLLALLPSGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL
ELTYLPANASLSFLQDIQEVQGYVLIAHSQVRQIPLQRLRIVRGTQLFEDNYALAVLDNG
DPLEGGIPAPGAAPGGLRELQLRSLTEILKGGVLIQRSPQLCHQDTILWKDVFHKNNQLA
LTLIDTNRSRACPPCSPACKDAHCWGASSGDCQSLTRTVCAGGCARCKGPQPTDCCHEQC
AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTSCP
YNYLSTDVGSCTLVCPLNNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSAN
IQEFAGCKKIFGSLAFLPESFEGDPASNTAPLQPEQLRVFEALEEITGYLYISAWPDSLP
NLSVFQNLRVIRGRVLHDGAYSLTLQGLGISWLGLRSLRELGSGLALIHRNARLCFVHTV
PWDQLFRNPHQALLHSANRPEEECVGEGLACYPLCAHGHCWGPGPTQCVNCSQFLRGQEC
VEECRVLQGLPREYVKDRYCLPCHSECQPQNGSVTCFGSEADQCVACAHYKDPPFCVARC
PSGVKPDLSFMPIWKFADEEGTCQPCPINCTHSCADLDEKGCPAEQRASPVTSIIAAVVG
ILLAVVVGLVLGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL
RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP
YVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVR
LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESLLRRRFT
HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM
IDSECRPRFRELVAEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA
EEYLVPQQGFFCPEPTPGAGGTAHRRHRSSSTRSGGGELTLGLEPSEEEPPKSPLAPSEG
AGSDVFDGDLGMGAAKGLQSLPSQDPSPLQRYSEDPTVPLPPETDGYVAPLTCSPQPEYV
NQPEVWPQPPSPLEGPLPPSRPAGATLERPKTLSPKTLSPGKNGVVKDVFAFGSAVENPE
YLAPRGRAAPQPHPPPAFSPAFDNLYYWDQDPSERGSPPSTFEGTPTAENPEYLGLDVPV
NT seq 3783 nt   +upstreamnt  +downstreamnt
atggagctggcggcctggtgccgctgggggctccttctcgccctcctgccctccggagcc
gcgggcacccaagtgtgcaccggcacagacatgaagctccggctcccggccagtcccgag
acccacctggatatgctccgccacctgtaccagggctgtcaagtggtacaggggaacctg
gagctcacttacctgcctgccaatgccagcctgtccttcctgcaggatatccaggaggtg
cagggctatgtgctcattgctcacagccaagtgaggcagatcccactgcagaggctacga
attgtgcgaggcacccagctctttgaggacaactacgccctggccgtgctggacaatgga
gacccgctggagggtggcatccctgcaccaggggcggccccaggagggctgcgggagctg
cagcttcgaagcctcacagagatcctgaagggaggggtcttgattcagcggagcccgcag
ctctgccaccaggacacgattttatggaaggacgtcttccataagaacaaccagctggcc
ctcacgctgatagacaccaaccgctctcgggcctgcccaccctgttctccagcttgtaaa
gacgcccactgctggggggccagctccggggactgtcagagcttgacgcggactgtctgt
gcggggggctgtgcccgctgcaagggcccacaacccaccgactgctgccacgagcagtgt
gctgctggctgcacgggccccaagcactctgactgcctggcctgccttcacttcaaccac
agtggcatctgtgagctgcactgcccagccctggtcacctacaacacggacaccttcgaa
tccatgcccaaccctgagggccgatataccttcggggccagctgtgtgacctcctgtccc
tacaactacctgtctacggatgtgggatcctgcaccctggtctgtcccctgaacaaccaa
gaggtgacggctgaggatgggacacagcggtgcgagaaatgcagcaagccctgtgcccga
gtgtgctacggtctgggcatggagcacctgcgggaggtgagagcggtcaccagtgcgaac
atccaggagtttgccggctgcaagaagatctttggaagcctggcatttttgccagagagc
tttgagggggacccagcctccaacactgcccccctacagcctgagcagctcagagtgttt
gaggctctggaggagatcacaggttacctgtacatctcagcgtggccagacagcctgcct
aacctcagtgtcttccagaacctgcgagtaatccggggacgagttctgcatgatggtgcc
tactcgctgaccctgcaagggctgggcatcagctggctggggctgcgctcgctgcgggaa
ctgggcagtgggctggccctcatccaccgcaacgcccgcctttgcttcgtgcacacggtg
ccctgggaccagctcttccggaacccccaccaggccctgctccatagtgccaaccggcca
gaggaggagtgcgtgggcgagggcctggcctgctacccgctgtgcgcccatgggcactgc
tggggtccagggccgacccagtgcgtcaactgcagccaattccttcggggccaggagtgc
gtggaagaatgccgagtactgcaggggctgccccgagagtatgtgaaggacaggtactgt
ctgccgtgccactcagagtgtcagccccagaatggctcagtgacctgcttcggatcggag
gctgaccagtgtgtggcctgcgcccactacaaggaccctcccttctgtgtggctcgctgc
cccagtggtgtgaaacctgacctgtccttcatgcccatctggaagttcgcagatgaggag
ggcacttgccagccgtgccccatcaactgcacccactcctgtgcggacctggacgagaag
ggctgtcccgccgagcagagagccagccctgtgacatccatcattgccgctgtggtgggc
attctgctggctgtggtcgtggggctggtcctcggcatcctgatcaagcgaaggcggcag
aagatccggaagtacactatgcggaggctgctgcaggaaaccgagctggtggagccgctg
acgcctagtggagcgatgcccaaccaggctcagatgcggatcctgaaagagacagagctg
aggaaggtgaaggtgcttggatccggagcttttggcacagtctacaagggcatctggatc
cctgatggggaaaatgtgaaaatcccagtggccatcaaagtgttgagggaaaacacatct
cccaaagccaacaaagaaatcttggacgaagcatatgtgatggctggagtgggctccccg
tatgtgtcccgcctcctgggcatctgcctgacatccacggtgcagctggtgacacagctt
atgccctacggctgcctcttagaccatgtccgagaacaccgtgggcgcctgggctcccag
gacttgctgaactggtgtgtgcagattgccaaggggatgagctacttggaggatgtccgg
ctggtgcacagggacctggctgcccggaatgtgctggtcaagagtcccaaccatgtcaag
attacagatttcgggctggctcggttgctggacatcgacgagacagagtaccatgcggat
gggggcaaggtgcccatcaagtggatggcgctggagtcccttctccgccggcggttcacc
caccagagtgatgtgtggagctatggtgtgactgtgtgggaactgatgacttttggggcc
aaaccttatgatgggatcccagcccgggagatccctgacctgctggagaagggggaacgg
ctgccccagccccccatctgcaccattgatgtctacatgatcatggtcaagtgctggatg
atagactctgaatgccgaccccggttccgggagttggtggccgaattctcacgtatggcc
agggacccccagcgctttgtggtcattcagaatgaagacttgggccccgccagccccttg
gacagcaccttctaccgttcactactggaagatgatgacatgggggacctggtggatgct
gaggagtacctggtaccccagcagggtttcttctgcccagaacctaccccaggggctggg
ggcactgcccaccgacggcaccgcagctcatccaccaggagtggcggtggtgagctgact
ctaggactggagccctccgaggaggagccccccaagtctccactggcaccctcagagggc
gctggctctgacgtgtttgatggtgacttgggaatgggggcagccaaggggctgcagagc
cttccctcacaggaccccagccctctccagcggtacagtgaggaccctacggtacccttg
ccccctgagactgatggctacgtcgcccccctgacctgcagcccccagcctgaatatgtg
aaccagccagaagtttggccgcagcccccctcgcccctagaaggccctctgcctccttcc
cgaccggctggtgccactctggaaaggcccaagactctgtcccccaagactctctcccct
ggcaagaatggggttgtcaaagacgtttttgcctttgggagtgctgtggagaatccggag
tacctggcaccccggggcagagctgcccctcagccccaccctcctccagccttcagccca
gcctttgacaacctgtattactgggaccaggatccatcagagcggggctctccacccagc
acctttgaagggacccctacagcagagaacccggagtacctggggctggacgtgccagtg
tga

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (22)   
   KEGG PATHWAY (22)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (32)   
   KEGG ORTHOLOGY (1)   
   RefGene (26)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (20)   
   RefSeq(nuc) (2)   
   GenBank (9)   
   EMBL (9)   
Protein domain (8)   
   Pfam (8)   
All databases (91)   

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