KEGG   Canis lupus familiaris (dog): 607023
Entry
607023            CDS       T01007                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa01522  Endocrine resistance
cfa04010  MAPK signaling pathway
cfa04015  Rap1 signaling pathway
cfa04068  FoxO signaling pathway
cfa04071  Sphingolipid signaling pathway
cfa04114  Oocyte meiosis
cfa04148  Efferocytosis
cfa04218  Cellular senescence
cfa04261  Adrenergic signaling in cardiomyocytes
cfa04370  VEGF signaling pathway
cfa04380  Osteoclast differentiation
cfa04550  Signaling pathways regulating pluripotency of stem cells
cfa04611  Platelet activation
cfa04613  Neutrophil extracellular trap formation
cfa04620  Toll-like receptor signaling pathway
cfa04621  NOD-like receptor signaling pathway
cfa04622  RIG-I-like receptor signaling pathway
cfa04625  C-type lectin receptor signaling pathway
cfa04657  IL-17 signaling pathway
cfa04658  Th1 and Th2 cell differentiation
cfa04659  Th17 cell differentiation
cfa04660  T cell receptor signaling pathway
cfa04664  Fc epsilon RI signaling pathway
cfa04668  TNF signaling pathway
cfa04670  Leukocyte transendothelial migration
cfa04714  Thermogenesis
cfa04722  Neurotrophin signaling pathway
cfa04723  Retrograde endocannabinoid signaling
cfa04728  Dopaminergic synapse
cfa04750  Inflammatory mediator regulation of TRP channels
cfa04912  GnRH signaling pathway
cfa04914  Progesterone-mediated oocyte maturation
cfa04917  Prolactin signaling pathway
cfa04926  Relaxin signaling pathway
cfa04932  Non-alcoholic fatty liver disease
cfa04933  AGE-RAGE signaling pathway in diabetic complications
cfa04935  Growth hormone synthesis, secretion and action
cfa04936  Alcoholic liver disease
cfa05014  Amyotrophic lateral sclerosis
cfa05020  Prion disease
cfa05022  Pathways of neurodegeneration - multiple diseases
cfa05132  Salmonella infection
cfa05133  Pertussis
cfa05135  Yersinia infection
cfa05140  Leishmaniasis
cfa05142  Chagas disease
cfa05145  Toxoplasmosis
cfa05152  Tuberculosis
cfa05161  Hepatitis B
cfa05163  Human cytomegalovirus infection
cfa05167  Kaposi sarcoma-associated herpesvirus infection
cfa05169  Epstein-Barr virus infection
cfa05170  Human immunodeficiency virus 1 infection
cfa05171  Coronavirus disease - COVID-19
cfa05205  Proteoglycans in cancer
cfa05208  Chemical carcinogenesis - reactive oxygen species
cfa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cfa05415  Diabetic cardiomyopathy
cfa05417  Lipid and atherosclerosis
cfa05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    607023 (MAPK12)
   04015 Rap1 signaling pathway
    607023 (MAPK12)
   04370 VEGF signaling pathway
    607023 (MAPK12)
   04668 TNF signaling pathway
    607023 (MAPK12)
   04068 FoxO signaling pathway
    607023 (MAPK12)
   04071 Sphingolipid signaling pathway
    607023 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    607023 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    607023 (MAPK12)
   04218 Cellular senescence
    607023 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    607023 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    607023 (MAPK12)
   04613 Neutrophil extracellular trap formation
    607023 (MAPK12)
   04620 Toll-like receptor signaling pathway
    607023 (MAPK12)
   04621 NOD-like receptor signaling pathway
    607023 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    607023 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    607023 (MAPK12)
   04660 T cell receptor signaling pathway
    607023 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    607023 (MAPK12)
   04659 Th17 cell differentiation
    607023 (MAPK12)
   04657 IL-17 signaling pathway
    607023 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    607023 (MAPK12)
   04670 Leukocyte transendothelial migration
    607023 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    607023 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    607023 (MAPK12)
   04917 Prolactin signaling pathway
    607023 (MAPK12)
   04926 Relaxin signaling pathway
    607023 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    607023 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    607023 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    607023 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    607023 (MAPK12)
   04722 Neurotrophin signaling pathway
    607023 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    607023 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    607023 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    607023 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    607023 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    607023 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    607023 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    607023 (MAPK12)
   05161 Hepatitis B
    607023 (MAPK12)
   05171 Coronavirus disease - COVID-19
    607023 (MAPK12)
   05163 Human cytomegalovirus infection
    607023 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    607023 (MAPK12)
   05169 Epstein-Barr virus infection
    607023 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    607023 (MAPK12)
   05135 Yersinia infection
    607023 (MAPK12)
   05133 Pertussis
    607023 (MAPK12)
   05152 Tuberculosis
    607023 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    607023 (MAPK12)
   05140 Leishmaniasis
    607023 (MAPK12)
   05142 Chagas disease
    607023 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    607023 (MAPK12)
   05020 Prion disease
    607023 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    607023 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    607023 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    607023 (MAPK12)
   05415 Diabetic cardiomyopathy
    607023 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    607023 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    607023 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    607023 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    607023 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cfa01001]
    607023 (MAPK12)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     607023 (MAPK12)
Protein kinases [BR:cfa01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   607023 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH RIO1 Haspin_kinase
Other DBs
NCBI-GeneID: 607023
NCBI-ProteinID: XP_038491608
Ensembl: ENSCAFG00000000685
VGNC: 42993
Position
10:16964857..16973137
AA seq 379 aa
MSSPPPARRGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRSGARVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENAPTPPGTPASPQVIGLLDVFTPDETLDDFTDFYLV
MPFMGTDLGKLMKHEKLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELK
ILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSAGCIMAEMITGKTLFKG
SDHLDQLKEIMKVTGTPPAEFVQRLQSAEAKNYMKGLPELQKKDFASILTNASPLAVNLL
EKMLVLDAEQRVTAAEALTHPYFESLQDTEEEPKAQKYDESFDDVDRTLDEWKRVTYKEV
LSFKPPRQLGTKVSKETAL
NT seq 1140 nt   +upstreamnt  +downstreamnt
atgagctccccgccgcccgcccgcaggggcttctaccgccaagaggtgaccaagacggcg
tgggaggtgcgcgcagtgtaccaggacctgcagcccgtgggctcgggcgcctacggggcc
gtgtgctcggcggtggacagccgcagcggcgcccgggtggccatcaagaagctgtaccgg
cccttccagtccgagctgtttgccaagcgcgcctaccgcgagctgcgcctcctcaagcac
atgcgccacgagaacgcccccactccaccaggtactccggcctccccccaggtcattggg
ttgctggacgtgttcactcctgatgaaaccctggatgatttcacagacttttacctggtg
atgccattcatgggaactgacctgggcaagctcatgaagcacgagaagctgagtgaggat
cgaatccagttccttgtgtaccagatgctgaaggggctaaagtacatccacgccgccggc
atcatccacagggacctgaagcccggcaatctggcagtgaatgaggactgtgagctgaag
atcctggacttcggcctggccaggcaggcagatagcgagatgactggctacgtggtgacc
cggtggtaccgggcgcctgaggtcatcttgaactggatgcgctacacgcagacagtggac
atctggtccgcgggctgcatcatggcagagatgatcacggggaagacactgttcaagggc
agtgaccacctggaccagctgaaggagatcatgaaggtgacagggacgcctcccgccgag
ttcgtgcagaggctgcagagtgccgaggcgaagaactacatgaagggcctccccgagttg
cagaagaaggattttgcctccatcctgactaacgcaagccccctggccgtgaacctcctg
gagaagatgctggtgctggacgcagagcagcgggtgacggcggccgaggcgctgacccac
ccgtacttcgagtccctgcaggacacggaggaggagcccaaggcccagaagtacgacgag
tcctttgatgatgtggaccgcacgctggacgagtggaagcgtgtcacatataaagaagtg
ctcagcttcaagcctccccggcagctggggaccaaggtctccaaggagacagccctgtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (60)   
   KEGG PATHWAY (60)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (9)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (30)   
   RefSeq(pep) (30)   
DNA sequence (30)   
   RefSeq(nuc) (30)   
Protein domain (6)   
   Pfam (6)   
All databases (140)   

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