KEGG   Cricetulus griseus (Chinese hamster): 100689304
Entry
100689304         CDS       T02813                                 
Symbol
Top2a
Name
(RefSeq) DNA topoisomerase 2-alpha
  KO
K03164  DNA topoisomerase II [EC:5.6.2.2]
Organism
cge  Cricetulus griseus (Chinese hamster)
Pathway
cge01524  Platinum drug resistance
Brite
KEGG Orthology (KO) [BR:cge00001]
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    100689304 (Top2a)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:cge03032]
    100689304 (Top2a)
   03036 Chromosome and associated proteins [BR:cge03036]
    100689304 (Top2a)
Enzymes [BR:cge01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.2  DNA topoisomerase (ATP-hydrolysing)
     100689304 (Top2a)
DNA replication proteins [BR:cge03032]
 Eukaryotic type
  DNA Topoisomerases
   100689304 (Top2a)
Chromosome and associated proteins [BR:cge03036]
 Eukaryotic type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    100689304 (Top2a)
  Centrosome formation proteins
   Centriole proteins
    100689304 (Top2a)
SSDB
Motif
Pfam: DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT HATPase_c Toprim
Other DBs
NCBI-GeneID: 100689304
NCBI-ProteinID: NP_001233667
UniProt: P41515 G3I5N5
Position
7:complement(112071654..112102887)
AA seq 1526 aa
MELSPLQPVNENMQMNKKKNEDAKKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQM
WVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNN
GKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTRFTVET
ASKEYKKMFKQTWMDNMGRAGDMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVR
RAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNALKVVHEQVNPRWEVCL
TMSEKGFQQISFVNSIATSKGGRHVDYVADQIVSKLVDVVKKKNKGGVAVKAHQVKNHMW
IFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQI
QLNKKCSAVKHNRIKGIPKLDDANDAGSRNSTECTLILTEGDSAKTLAVSGLGVVGRDKY
GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTD
QDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQELAFYSLPEFEEWKSS
TPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQVDDR
KEWLTHFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDG
LKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNL
NLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLTRLLFPPKDDHTLKFLYDDNQRVEPEWY
IPIIPMVLINGAEGIGTGWSCKIPNFDIREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEE
LASNQYVINGEVAILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYH
TDTTVKFVIKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILKD
FFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRG
YDSDPVKAWKEAQQKVPDEEENEESDNENSDSVAESGPTFNYLLDMPLWYLTKEKKDELC
KQRNEKEQELNTLKNKSPSDLWKEDLAVFIEELEVVEAKEKQDEQVGLPGKGGKAKGKKA
QMSEVLPSPHGKRVIPQVTMEMKAEAEKKIRKKIKSENVEGTPTENGLELGSLKQRIEKK
QKKEPGAMTKKQTTLAFKPIKKGKKRNPWSDSESDMSSNESNVDVPPREKDPRRAATKAK
FTMDLDSDEDFSGSDGKDEDEDFFPLDTTPPKTKIPQKNTKKALKPQKSAMSGDPESDEK
DSVPASPGPPAADLPADTEQLKPSSKQTVAVKKTATKSQSSTSTAGTKKRAVPKGSKSDS
ALNAHGPEKPVPAKAKNSRKRKQSSSDDSDSDFEKVVSKVAASKKSKGENQDFRVDLDET
MVPRAKSGRAKKPIKYLEESDDDDLF
NT seq 4581 nt   +upstreamnt  +downstreamnt
atggagttgtcgccgctgcagcctgtaaatgaaaatatgcaaatgaacaaaaagaaaaat
gaagatgccaagaaaaggctgtctattgaaagaatctatcagaaaaaaacacaattggaa
catatattgctccgcccagatacctacattggctctgtggaattagttacccagcaaatg
tgggtttacgatgaagatgttggcattaactacagggaagtaacttttgttcctggtttg
tataaaatctttgatgagattctagttaatgctgcagacaacaaacaaagggacccaaaa
atgtcttgtattagagtcacaattgatccagaaaataatttaattagtatatggaataat
ggaaaaggaattcctgttgttgaacacaaagttgagaaaatgtatgtcccagctctcata
tttggacagctcttaacctctagtaactatgatgatgatgaaaagaaagtaacaggtggt
cgaaatggttatggagccaaactgtgtaacatattcagcaccagatttactgtggaaact
gccagtaaagaatacaagaaaatgttcaaacagacatggatggataacatggggagagct
ggtgacatggaactcaagccctttaatggagaagattatacatgtattaccttccagcct
gatttatcaaagtttaagatgcaaagccttgacaaagatattgttgcactgatggttaga
agggcatatgatattgctggttccactaaagatgtcaaagttttccttaatggaaataag
ctgccagtaaaagggttccgcagctatgtggatatgtatttgaaggataaattagatgaa
actggtaacgcactgaaagtagtacatgaacaagtaaacccaaggtgggaagtgtgctta
acaatgagtgaaaaaggctttcaacaaattagctttgtcaatagcattgctacttctaag
ggtggcagacatgttgattatgtagctgatcagattgtgagtaaacttgttgatgtggtg
aagaagaagaacaagggtggtgttgcagtgaaagcccaccaggtgaaaaatcacatgtgg
atttttgtaaatgccttgattgaaaacccaacctttgactctcagacaaaagaaaacatg
actttacaggccaagagctttggatcaacatgtcaattaagtgaaaaattcatcaaagct
gcaattggctgtggtattgtcgaaagcatactaaactgggtgaagtttaaggcccaaatc
cagttaaacaagaaatgttcagctgtaaaacataacagaatcaagggaatccccaaactt
gatgatgccaacgatgcagggagtcgaaactccactgaatgtacacttatcctaactgag
ggagactcagccaaaacactggcagtttcaggtcttggtgttgttggaagagataaatat
ggggtatttcctcttagaggaaaaatactcaatgtgcgagaagcttctcataaacagatc
atggaaaatgctgaaattaacaatatcatcaagattgtgggtcttcagtataagaaaaac
tatgaagatgaagattcattgaaaactcttcgttatgggaagataatgattatgacagat
caggatcaagatggttcccatatcaaaggcttgctgatcaattttatccatcacaactgg
ccctctcttctgcgtcatcgttttctagaggaatttattactcccattgtaaaggtgtct
aaaaacaagcaagaattggcattctatagtcttcctgagtttgaagaatggaagagttct
actccaaatcataaaaaatggaaagtcaaatattacaaaggtttgggcaccagcacatca
aaggaagctaaagaatattttgcagatatgaaaagacatcgtattcagttcaaatactct
ggacctgaagatgatgctgcaatcagcctggcctttagtaagaaacaggtcgatgatcga
aaggaatggttgactcatttcatggaagatagacggcagcggaagttacttggccttcct
gaggattatttgtatggacaaaccactacttacctgacgtataatgacttcataaacaag
gaacttattctgttctcaaattctgataatgaaagatctatcccatctatggtagatggt
ttgaaaccaggtcagagaaaggttttgtttacttgtttcaaacggaatgacaagcgagaa
gtgaaggttgcccagttagctgggtcagtggcagaaatgtcctcttatcaccatggtgag
atgtcactgatgatgaccattatcaatttggctcagaattttgtgggtagtaataatttg
aaccttttgcagcccattggtcagtttggtaccaggctgcatggtggcaaggattcagct
agtcctcgatacatctttactatgctcagccctttgactcggttgttatttccaccaaaa
gatgatcacacattaaagtttttatatgatgacaatcagcgtgttgaacctgaatggtac
attcctattattcccatggtgctgataaatggcgctgagggaattggtaccgggtggtcc
tgcaaaatccccaactttgatatccgtgaagtcgtaaataatatcagacgactgttggat
ggagaagagcctctgcccatgctcccaagttacaaaaatttcaaaggtactattgaagag
ctggcttctaatcagtatgtgattaatggagaagtagctattctaaattccacaaccatt
gaaatctcagagcttcccatcagaacgtggactcagacttacaaagaacaggttctagaa
cccatgttgaatggtactgagaagacaccccctcttataacagactatagggaatatcac
acagacaccactgtcaagtttgtcataaagatgactgaagaaaaattagcagaggcagag
agagtgggactacacaaagtcttcaaactgcagactagtctcacttgcaactctatggtg
ctttttgaccatgtaggttgcttaaagaaatatgacactgtgttggatattctaaaagac
ttctttgagctcaggcttaaatattatggattaagaaaagaatggcttctgggaatgctt
ggtgcagaatctgctaaactgaataatcaagctcgttttatattagagaaaatagatggc
aaaataatcattgaaaataaacctaaaaaagagctaattaaagttctaattcagagagga
tatgattcagatcctgtaaaagcctggaaagaagctcagcaaaaggtcccagatgaagaa
gaaaatgaagaaagtgacaatgaaaacagtgactctgtagcagaatctggaccgactttc
aattaccttcttgatatgcccctttggtatctaaccaaagaaaagaaagatgaactgtgc
aaacaaagaaatgaaaaggaacaagagctcaacacattaaagaacaagagtccatcagat
ttgtggaaggaggatttggcagtttttattgaagaactggaggttgttgaagccaaggaa
aagcaagatgaacaagtaggacttcctggaaaaggggggaaagcaaaagggaagaaagca
caaatgtctgaagtcttgccttctcctcacggaaaaagagttattccccaagtgaccatg
gagatgaaagcagaagcagagaagaaaattaggaagaaaattaagagtgaaaacgttgag
ggcactcctactgagaatggtctggaactaggaagcttaaaacaaagaatagagaagaag
cagaagaaagagccaggtgccatgacaaagaagcagactacattggcttttaagccaatc
aaaaaagggaaaaagagaaacccctggtctgattctgaatcagatatgagcagtaatgaa
agtaatgttgatgtccctccacgagaaaaggacccacgaagagctgcaacaaaagccaaa
ttcacgatggatttggattcagatgaagatttctcaggttctgatggaaaggatgaagat
gaagattttttcccactagatactactccacctaagaccaaaattccccaaaaaaatact
aagaaagcactgaagccacaaaagagtgccatgtctggtgaccctgaaagtgatgaaaag
gacagtgtgccagcttctccaggccctcctgctgctgacttgccagctgacactgaacag
ttaaagccatcttccaaacagactgtggcagtgaagaagacagccaccaaaagccagtct
tcaacatccactgctggtaccaaaaagagagctgtaccaaaaggaagcaaatcagattca
gccttgaatgctcatggccctgaaaagcctgtgcctgccaaagccaagaacagccgcaaa
aggaagcagtcctcttctgatgattctgactctgattttgagaaagtagtctccaaagtt
gctgcaagcaagaaatccaagggagagaatcaggatttccgagtggacttagatgaaact
atggttcctcgagcaaaatctggacgagcaaagaagcctatcaaatacctggaggagtca
gatgatgatgatcttttctga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (38)   
   KEGG ORTHOLOGY (1)   
   RefGene (34)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (11)   
   RefSeq(nuc) (1)   
   GenBank (5)   
   EMBL (5)   
Protein domain (6)   
   Pfam (6)   
All databases (66)   

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