KEGG   Cricetulus griseus (Chinese hamster): 100774853
Entry
100774853         CDS       T02813                                 
Symbol
Pdha1
Name
(RefSeq) pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
  KO
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
Organism
cge  Cricetulus griseus (Chinese hamster)
Pathway
cge00010  Glycolysis / Gluconeogenesis
cge00020  Citrate cycle (TCA cycle)
cge00620  Pyruvate metabolism
cge00785  Lipoic acid metabolism
cge01100  Metabolic pathways
cge01200  Carbon metabolism
cge01210  2-Oxocarboxylic acid metabolism
cge04066  HIF-1 signaling pathway
cge04922  Glucagon signaling pathway
cge05230  Central carbon metabolism in cancer
cge05415  Diabetic cardiomyopathy
Module
cge_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:cge00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    100774853 (Pdha1)
   00020 Citrate cycle (TCA cycle)
    100774853 (Pdha1)
   00620 Pyruvate metabolism
    100774853 (Pdha1)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    100774853 (Pdha1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    100774853 (Pdha1)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    100774853 (Pdha1)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    100774853 (Pdha1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    100774853 (Pdha1)
Enzymes [BR:cge01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.1  pyruvate dehydrogenase (acetyl-transferring)
     100774853 (Pdha1)
SSDB
Motif
Pfam: E1_dh DXP_synthase_N TPP_enzyme_C
Other DBs
NCBI-GeneID: 100774853
NCBI-ProteinID: NP_001239228
UniProt: G3H5K6
Position
X:complement(95070241..95084761)
AA seq 390 aa
MRKMLAAVSRVLAGAAQKPASRVLIASRNFANDATFDIKKCDLHRLEEGPPVTTVLTRED
GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
HGFTFTRGLPVRAILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
DYYKRGDFIPGLRVDGMDILCVREATKFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
LEELGYHIYSSDPPFEVRGANQWIKFKSVS
NT seq 1173 nt   +upstreamnt  +downstreamnt
atgaggaagatgcttgccgctgtgtcccgcgtgttggcaggcgctgcacagaagccggca
agcagagtgctaatagcttcccgtaattttgcaaatgatgctacatttgacattaagaaa
tgtgaccttcatcggctagaagagggtcctccagtcaccacagtgctcaccagagaagat
gggctcaagtactacaggatgatgcagactgtgcggcgaatggagctaaaggcagatcag
ttgtataaacagaaaattattcgtggtttctgtcacttgtgtgatggtcaggaagcctgc
tgcgtgggcctggaggctggcataaaccccacggaccatctcatcacagcctatcgagcg
catggcttcaccttcactcggggcctacctgtccgagcaattcttgcagagctaacagga
cgaagaggaggttgtgctaaagggaaaggcggatccatgcacatgtacgccaagaacttc
tatggaggcaatggcatcgttggagctcaggtgcccctaggagcagggattgctctggcc
tgcaagtacaatggaaaagatgaggtctgtttgacactatatggtgatggcgctgctaat
cagggtcaaatatttgaagcttacaatatggcagcattgtggaaattaccttgtattttc
atctgtgaaaataaccgctatggcatggggacatctgtcgagagagcagctgccagtaca
gattactacaaaagaggagattttattcctggactgagggtagatggaatggatatcttg
tgtgtccgagaggcaacaaagtttgcagctgcctattgtaggtctggtaaggggcccatc
ctgatggagttacagacttatcgttaccatggacatagtatgagtgaccctggagtcagt
taccgcactcgagaagaaatccaagaagtaagaagtaagagcgaccctattatgcttctc
aaggatagaatggtgaacagcaatctcgcaagtgttgaagaattaaaggagattgatgtg
gaagtgaggaaagaaatcgaggatgctgcccagtttgctacagctgatccagagccgccc
ttggaggaactaggctatcacatctacagcagcgatcctccctttgaagtgcgtggtgcc
aaccagtggatcaagtttaagtcagtcagttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (12)   
   KEGG PATHWAY (11)   
   KEGG MODULE (1)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (9)   
   RefSeq(nuc) (1)   
   GenBank (4)   
   EMBL (4)   
Protein domain (3)   
   Pfam (3)   
All databases (60)   

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