KEGG   Callithrix jacchus (white-tufted-ear marmoset): 100387394Help
Entry
100387394         CDS       T03264                                 

Gene name
MAP2K1
Definition
(RefSeq) mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
cjc  Callithrix jacchus (white-tufted-ear marmoset)
Pathway
cjc01521  EGFR tyrosine kinase inhibitor resistance
cjc01522  Endocrine resistance
cjc04010  MAPK signaling pathway
cjc04012  ErbB signaling pathway
cjc04014  Ras signaling pathway
cjc04015  Rap1 signaling pathway
cjc04022  cGMP-PKG signaling pathway
cjc04024  cAMP signaling pathway
cjc04062  Chemokine signaling pathway
cjc04066  HIF-1 signaling pathway
cjc04068  FoxO signaling pathway
cjc04071  Sphingolipid signaling pathway
cjc04072  Phospholipase D signaling pathway
cjc04114  Oocyte meiosis
cjc04140  Autophagy - animal
cjc04150  mTOR signaling pathway
cjc04151  PI3K-Akt signaling pathway
cjc04210  Apoptosis
cjc04218  Cellular senescence
cjc04270  Vascular smooth muscle contraction
cjc04370  VEGF signaling pathway
cjc04371  Apelin signaling pathway
cjc04380  Osteoclast differentiation
cjc04510  Focal adhesion
cjc04540  Gap junction
cjc04550  Signaling pathways regulating pluripotency of stem cells
cjc04620  Toll-like receptor signaling pathway
cjc04650  Natural killer cell mediated cytotoxicity
cjc04660  T cell receptor signaling pathway
cjc04662  B cell receptor signaling pathway
cjc04664  Fc epsilon RI signaling pathway
cjc04666  Fc gamma R-mediated phagocytosis
cjc04668  TNF signaling pathway
cjc04720  Long-term potentiation
cjc04722  Neurotrophin signaling pathway
cjc04725  Cholinergic synapse
cjc04726  Serotonergic synapse
cjc04730  Long-term depression
cjc04810  Regulation of actin cytoskeleton
cjc04910  Insulin signaling pathway
cjc04912  GnRH signaling pathway
cjc04914  Progesterone-mediated oocyte maturation
cjc04915  Estrogen signaling pathway
cjc04916  Melanogenesis
cjc04917  Prolactin signaling pathway
cjc04919  Thyroid hormone signaling pathway
cjc04921  Oxytocin signaling pathway
cjc04926  Relaxin signaling pathway
cjc04928  Parathyroid hormone synthesis, secretion and action
cjc04934  Cushing syndrome
cjc05020  Prion diseases
cjc05034  Alcoholism
cjc05160  Hepatitis C
cjc05161  Hepatitis B
cjc05163  Human cytomegalovirus infection
cjc05164  Influenza A
cjc05165  Human papillomavirus infection
cjc05166  Human T-cell leukemia virus 1 infection
cjc05167  Kaposi sarcoma-associated herpesvirus infection
cjc05170  Human immunodeficiency virus 1 infection
cjc05200  Pathways in cancer
cjc05205  Proteoglycans in cancer
cjc05206  MicroRNAs in cancer
cjc05210  Colorectal cancer
cjc05211  Renal cell carcinoma
cjc05212  Pancreatic cancer
cjc05213  Endometrial cancer
cjc05214  Glioma
cjc05215  Prostate cancer
cjc05216  Thyroid cancer
cjc05218  Melanoma
cjc05219  Bladder cancer
cjc05220  Chronic myeloid leukemia
cjc05221  Acute myeloid leukemia
cjc05223  Non-small cell lung cancer
cjc05224  Breast cancer
cjc05225  Hepatocellular carcinoma
cjc05226  Gastric cancer
cjc05230  Central carbon metabolism in cancer
cjc05231  Choline metabolism in cancer
cjc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Module
cjc_M00687  MAPK (ERK1/2) signaling
Brite
KEGG Orthology (KO) [BR:cjc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100387394 (MAP2K1)
   04015 Rap1 signaling pathway
    100387394 (MAP2K1)
   04010 MAPK signaling pathway
    100387394 (MAP2K1)
   04012 ErbB signaling pathway
    100387394 (MAP2K1)
   04370 VEGF signaling pathway
    100387394 (MAP2K1)
   04371 Apelin signaling pathway
    100387394 (MAP2K1)
   04668 TNF signaling pathway
    100387394 (MAP2K1)
   04066 HIF-1 signaling pathway
    100387394 (MAP2K1)
   04068 FoxO signaling pathway
    100387394 (MAP2K1)
   04072 Phospholipase D signaling pathway
    100387394 (MAP2K1)
   04071 Sphingolipid signaling pathway
    100387394 (MAP2K1)
   04024 cAMP signaling pathway
    100387394 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    100387394 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    100387394 (MAP2K1)
   04150 mTOR signaling pathway
    100387394 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100387394 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    100387394 (MAP2K1)
   04210 Apoptosis
    100387394 (MAP2K1)
   04218 Cellular senescence
    100387394 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100387394 (MAP2K1)
   04540 Gap junction
    100387394 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    100387394 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100387394 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100387394 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    100387394 (MAP2K1)
   04660 T cell receptor signaling pathway
    100387394 (MAP2K1)
   04662 B cell receptor signaling pathway
    100387394 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    100387394 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    100387394 (MAP2K1)
   04062 Chemokine signaling pathway
    100387394 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100387394 (MAP2K1)
   04912 GnRH signaling pathway
    100387394 (MAP2K1)
   04915 Estrogen signaling pathway
    100387394 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    100387394 (MAP2K1)
   04917 Prolactin signaling pathway
    100387394 (MAP2K1)
   04921 Oxytocin signaling pathway
    100387394 (MAP2K1)
   04926 Relaxin signaling pathway
    100387394 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    100387394 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    100387394 (MAP2K1)
   04916 Melanogenesis
    100387394 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100387394 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    100387394 (MAP2K1)
   04726 Serotonergic synapse
    100387394 (MAP2K1)
   04720 Long-term potentiation
    100387394 (MAP2K1)
   04730 Long-term depression
    100387394 (MAP2K1)
   04722 Neurotrophin signaling pathway
    100387394 (MAP2K1)
  09158 Development
   04380 Osteoclast differentiation
    100387394 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100387394 (MAP2K1)
   05206 MicroRNAs in cancer
    100387394 (MAP2K1)
   05205 Proteoglycans in cancer
    100387394 (MAP2K1)
   05230 Central carbon metabolism in cancer
    100387394 (MAP2K1)
   05231 Choline metabolism in cancer
    100387394 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100387394 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100387394 (MAP2K1)
   05212 Pancreatic cancer
    100387394 (MAP2K1)
   05225 Hepatocellular carcinoma
    100387394 (MAP2K1)
   05226 Gastric cancer
    100387394 (MAP2K1)
   05214 Glioma
    100387394 (MAP2K1)
   05216 Thyroid cancer
    100387394 (MAP2K1)
   05221 Acute myeloid leukemia
    100387394 (MAP2K1)
   05220 Chronic myeloid leukemia
    100387394 (MAP2K1)
   05218 Melanoma
    100387394 (MAP2K1)
   05211 Renal cell carcinoma
    100387394 (MAP2K1)
   05219 Bladder cancer
    100387394 (MAP2K1)
   05215 Prostate cancer
    100387394 (MAP2K1)
   05213 Endometrial cancer
    100387394 (MAP2K1)
   05224 Breast cancer
    100387394 (MAP2K1)
   05223 Non-small cell lung cancer
    100387394 (MAP2K1)
  09164 Neurodegenerative disease
   05020 Prion diseases
    100387394 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    100387394 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100387394 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100387394 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    100387394 (MAP2K1)
   05164 Influenza A
    100387394 (MAP2K1)
   05161 Hepatitis B
    100387394 (MAP2K1)
   05160 Hepatitis C
    100387394 (MAP2K1)
   05163 Human cytomegalovirus infection
    100387394 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100387394 (MAP2K1)
   05165 Human papillomavirus infection
    100387394 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100387394 (MAP2K1)
   01522 Endocrine resistance
    100387394 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cjc01001]
    100387394 (MAP2K1)
Enzymes [BR:cjc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100387394 (MAP2K1)
Protein kinases [BR:cjc01001]
 Serine/threonine kinases: STE group
  STE7 family
   100387394 (MAP2K1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr Pkinase_fungal Haspin_kinase Seadorna_VP7 Kinase-like NAD_binding_6
Motif
Other DBs
NCBI-GeneID: 100387394
NCBI-ProteinID: XP_002753305
Ensembl: ENSCJAG00000007460
UniProt: U3CZR8
Position
10
AA seq 393 aa AA seqDB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt NT seq  +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctcggcggtt
aacgggaccagctctgcagagaccaacctggaggccttgcagaagaagctggaggagcta
gagcttgacgagcagcagcgaaagcgccttgaggcctttcttacccagaagcagaaggtg
ggagaactgaaggatgatgactttgagaagatcagtgagctgggggctggcaatggcggt
gtggttttcaaggtctcccacaagccttctggcctggtcatggccagaaagctaattcat
ctggagatcaaacctgcaatccggaaccagatcataagggagctgcaggttctgcatgag
tgcaactctccgtacatcgtgggcttctacggtgcattctacagcgatggcgagatcagt
atctgcatggagcacatggatgggggttccctggatcaagttctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
cgggagaagcacaagatcatgcacagagatgtcaagccctccaacatcctagtcaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tctgtgcagtcggacatctggagcatgggactctctctggtagagatggcagttgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagaccccacccaggccaaggacccctgggaggccccttagctcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaaactgcccagtggagtattcagcctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccctgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcccagcacaccaacccatgctgctggcgtctaa

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