KEGG   Callithrix jacchus (white-tufted-ear marmoset): 100387961
Entry
100387961         CDS       T03264                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
cjc  Callithrix jacchus (white-tufted-ear marmoset)
Pathway
cjc01521  EGFR tyrosine kinase inhibitor resistance
cjc01522  Endocrine resistance
cjc04010  MAPK signaling pathway
cjc04012  ErbB signaling pathway
cjc04068  FoxO signaling pathway
cjc04270  Vascular smooth muscle contraction
cjc04650  Natural killer cell mediated cytotoxicity
cjc04720  Long-term potentiation
cjc04726  Serotonergic synapse
cjc04730  Long-term depression
cjc04810  Regulation of actin cytoskeleton
cjc04910  Insulin signaling pathway
cjc04914  Progesterone-mediated oocyte maturation
cjc04928  Parathyroid hormone synthesis, secretion and action
cjc05010  Alzheimer disease
cjc05022  Pathways of neurodegeneration - multiple diseases
cjc05034  Alcoholism
cjc05160  Hepatitis C
cjc05161  Hepatitis B
cjc05200  Pathways in cancer
cjc05205  Proteoglycans in cancer
cjc05208  Chemical carcinogenesis - reactive oxygen species
cjc05210  Colorectal cancer
cjc05211  Renal cell carcinoma
cjc05212  Pancreatic cancer
cjc05213  Endometrial cancer
cjc05214  Glioma
cjc05215  Prostate cancer
cjc05218  Melanoma
cjc05219  Bladder cancer
cjc05220  Chronic myeloid leukemia
cjc05221  Acute myeloid leukemia
cjc05223  Non-small cell lung cancer
cjc05224  Breast cancer
cjc05225  Hepatocellular carcinoma
cjc05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:cjc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100387961 (ARAF)
   04012 ErbB signaling pathway
    100387961 (ARAF)
   04068 FoxO signaling pathway
    100387961 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100387961 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    100387961 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100387961 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    100387961 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    100387961 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100387961 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    100387961 (ARAF)
   04720 Long-term potentiation
    100387961 (ARAF)
   04730 Long-term depression
    100387961 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100387961 (ARAF)
   05205 Proteoglycans in cancer
    100387961 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    100387961 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100387961 (ARAF)
   05212 Pancreatic cancer
    100387961 (ARAF)
   05225 Hepatocellular carcinoma
    100387961 (ARAF)
   05226 Gastric cancer
    100387961 (ARAF)
   05214 Glioma
    100387961 (ARAF)
   05221 Acute myeloid leukemia
    100387961 (ARAF)
   05220 Chronic myeloid leukemia
    100387961 (ARAF)
   05218 Melanoma
    100387961 (ARAF)
   05211 Renal cell carcinoma
    100387961 (ARAF)
   05219 Bladder cancer
    100387961 (ARAF)
   05215 Prostate cancer
    100387961 (ARAF)
   05213 Endometrial cancer
    100387961 (ARAF)
   05224 Breast cancer
    100387961 (ARAF)
   05223 Non-small cell lung cancer
    100387961 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    100387961 (ARAF)
   05160 Hepatitis C
    100387961 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100387961 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    100387961 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    100387961 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100387961 (ARAF)
   01522 Endocrine resistance
    100387961 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cjc01001]
    100387961 (ARAF)
Enzymes [BR:cjc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100387961 (ARAF)
Protein kinases [BR:cjc01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   100387961 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 Pkinase_fungal zf-RING-like TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 100387961
NCBI-ProteinID: XP_008987456
Ensembl: ENSCJAG00000012431
UniProt: A0A5K1VS71
Position
X:46932433..46943158
AA seq 611 aa
MEPPRGPPANGAEPCRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTTCQQFYHSVQDLSRGSKQHEAPSNRPLNESL
TPQGPSLSPGSPCNQHCDPEHFPFPTPANAPLQRIRSTSTPNVHMVSSTAPMDSNLIQLT
GQSFSTDAASSRGGGDGAPRGSPSPVSVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLG
YRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEM
QVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQ
GMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAA
EVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKIS
SNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELP
ACLLSAARLVP
NT seq 1836 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaatggggccgagccgtgccgggcagtgggcacc
gtcaaagtgtacctgcccaacaagcaacgcacagtggtaactgtccgggatggcatgagt
gtctacgactctctagacaaggccctgaaggtgcggggtctaaatcaggactgctgtgtg
gtctaccgactcatcaagggacgaaagacggttactgcctgggacacagccatcgctccc
ctggatggcgaggagctcattgtcgaggtccttgaagatgttccgctgaccatgcacaat
tttgtacggaagaccttcttcagcctggcgttctgcgacttctgccttaagtttctgttc
catggcttccgttgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccacctgccaacagttctaccacagtgtccaggat
ttgtccagaggctccaaacagcatgaggctccctcaaaccgccccctgaatgagtcgcta
accccccagggtcccagcctttcccctggcagcccctgcaaccagcactgtgacccggag
cacttccccttccccaccccagccaatgctcccctgcagcgcatccgctccacgtccact
cccaacgtccatatggtcagctccacggctcccatggactccaacctcatccagctcact
ggccagagtttcagcactgatgctgccagtagtagaggaggtggagatggagccccccgg
gggagccccagcccagtcagcgtgtcctcggggaggaagtccccacattccaagtcacca
gcagagcagcgtgagcggaagtccttggctgatgacaagaaaaaagtgaagaacctgggg
taccgggactcaggctattactgggaggtaccacccagtgaggtgcagctgctgaagagg
attgggacaggctcgtttggcaccgtgtttcgagggcggtggcatggcgatgtggctgtg
aaggtgctcaaggtgtcccagcccacagctgagcaggcccaagccttcaagaacgagatg
caggtgctcaggaagacgcgacatgtcaacatcttgctgtttatgggcttcatgacccgg
ccgggatttgccatcatcacacagtggtgtgagggctccagcctctaccaccacctgcat
gtggccgacacacgcttcgacatggtccagctcatcgatgtggcccggcagactgcccag
ggcatggactacctccatgccaagaacatcatccaccgagatctcaagtctaacaacatc
ttcctacacgaggggctcacagtgaagattggtgactttggcttggccacggtgaagact
cgatggagcggggcccagcccttggagcagccctcaggctctgtgctgtggatggcagct
gaggtgatccgtatgcaggacccgaacccctacagcttccagtcagatgtctatgcctat
ggggttgtgctctacgagctcatgactggctcactgccttacagccacattggctgccgt
gaccagattatctttatggtgggccgtggctatctgtccccggacctcagcaaaatctcc
agcaactgccccaaggccatgcggcgcctgctgtctgactgcctcaagttccagcgggag
gagcggcccctcttcccccagattttggccacaattgagctgctgcaacggtcactcccc
aagattgagcggagtgcctcggaaccctccttgcaccgcacccaggctgatgagttgcct
gcctgcctactcagcgcagcccgccttgtgccttag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (36)   
   KEGG PATHWAY (36)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (4)   
DNA sequence (16)   
   RefSeq(nuc) (4)   
   GenBank (6)   
   EMBL (6)   
Protein domain (10)   
   Pfam (10)   
All databases (85)   

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