KEGG   PATHWAY: cme00030Help
cme00030                    Pathway                                

Pentose phosphate pathway - Cyanidioschyzon merolae
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
cme00030  Pentose phosphate pathway

Ortholog table
cme_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:cme00030]
cme_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:cme00030]
Other DBs
BSID: 17053
GO: 0006098
Cyanidioschyzon merolae [GN:cme]
CYME_CMO124C  glucose-6-phosphate isomerase [KO:K01810] [EC:]
CYME_CMT497C  glucose-6-phosphate isomerase [KO:K01810] [EC:]
CYME_CMR014C  glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:]
CYME_CMI224C  glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:]
CYME_CMC120C  6-Phospho-gluconolactonase [KO:K01057] [EC:]
CYME_CMS195C  6-phosphogluconate dehydrogenase, decarboxylating [KO:K00033] [EC:]
CYME_CMM231C  6-phosphogluconate dehydrogenase [KO:K00033] [EC:]
CYME_CML036C  6-phosphogluconate dehydrogenase [KO:K00033] [EC:]
CYME_CML059C  6-phosphogluconate dehydrogenase [KO:K00033] [EC:]
CYME_CMT633C  ribulose-5-phosphate 3-epimerase [KO:K01783] [EC:]
CYME_CMO229C  ribulose-5-phosphate 3-epimerase [KO:K01783] [EC:]
CYME_CMI084C  ribulose-5-phosphate-3-epimerase precursor [KO:K01783] [EC:]
CYME_CMO121C  transketolase [KO:K00615] [EC:]
CYME_CMO291C  ribose 5-phosphate isomerase [KO:K01807] [EC:]
CYME_CMI123C  probable ribokinase [KO:K00852] [EC:]
CYME_CMJ272C  phosphoglucomutase [KO:K01835] [EC:]
CYME_CMT285C  phosphoglucomutase [KO:K01835] [EC:]
CYME_CMQ067C  phosphomannomutase [KO:K15779] [EC:]
CYME_CMT113C  probable phosphoribosyl diphosphate synthetase; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:]
CYME_CMT292C  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:]
CYME_CMM249C  phosphoribosylpyrophosphate synthetase or ribose-phosphate pyrophosphokinase [KO:K00948] [EC:]
CYME_CMP292C  2-dehydro-3-deoxyphosphogluconate aldolase, 4-hydroxy-2-oxoglutarate aldolase [KO:K01625] [EC:]
CYME_CMT034C  NADP-dependent glyceraldehyde-3-phosphate dehydrogenase [KO:K00131] [EC:]
CYME_CME145C  fructose-1,6-biphosphate aldolase [KO:K01623] [EC:]
CYME_CMI049C  fructose-1,6-biphosphate aldolase, chloroplast precursor [KO:K01623] [EC:]
CYME_CMD041C  fructose-1,6-bisphosphatase [KO:K03841] [EC:]
CYME_CMP129C  fructose-1,6-bisphosphatase [KO:K03841] [EC:]
CYME_CMO245C  fructose-1,6-bisphosphatase precursor [KO:K03841] [EC:]
CYME_CMI162C  pyrophosphate-fructose-6-phosphate 1-phosphotransferase [KO:K00850] [EC:]
CYME_CMM196C  pyrophosphate--fructose-6-phosphate 1-phosphotransferase [KO:K00850] [EC:]
CYME_CMH052C  pyrophosphate--fructose-6-phosphate 1-phosphotransferase, beta subunit [KO:K00895] [EC:]
C00022  Pyruvate
C00031  D-Glucose
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
(map 3)
Nishizuka Y (ed).
[Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1980)
(map 4)
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
[Cellular Functions and Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1997)
Michal G.
Biochemical Pathways
Wiley (1999)
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
J Bacteriol 185:2793-801 (2003)
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
J Bacteriol 188:4698-704 (2006)
Kato N, Yurimoto H, Thauer RK
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
Biosci Biotechnol Biochem 70:10-21 (2006)
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
FEBS J 280:1126-38 (2013)
Reher M, Schonheit P
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
FEBS Lett 580:1198-204 (2006)
Reher M, Fuhrer T, Bott M, Schonheit P
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
J Bacteriol 192:964-74 (2010)
KO pathway

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