KEGG   COMPOUND: C02135Help
Entry
C02135                      Compound                               

Name
Angiotensin II;
Angiotensin;
Angiotonin;
Hypertensin
Formula
C50H71N13O12
Exact mass
1045.5345
Mol weight
1046.1786
Structure
Mol fileKCF fileDB search
Sequence
Asp Arg Val Tyr Ile His Pro Phe
  Organism
Human [HSA:183] [UP:ANGT_HUMAN]
  Type
Peptide
Comment
Human angiotensin II is illustrated. Angiotensin differs among species only in the amino acid residue in position 5 being either Val or Ile.
Reaction
Pathway
map04072  Phospholipase D signaling pathway
map04080  Neuroactive ligand-receptor interaction
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04614  Renin-angiotensin system
map04924  Renin secretion
map04925  Aldosterone synthesis and secretion
map04927  Cortisol synthesis and secretion
map04931  Insulin resistance
map04933  AGE-RAGE signaling pathway in diabetic complications
map04934  Cushing syndrome
map05200  Pathways in cancer
map05410  Hypertrophic cardiomyopathy (HCM)
map05414  Dilated cardiomyopathy (DCM)
map07229  Angiotensin receptor and endothelin receptor antagonists
Enzyme
Brite
Compounds with biological roles [BR:br08001]
 Hormones and transmitters
  Peptide hormones
   Angiotensin
    C02135  Angiotensin II
Bioactive peptides [BR:br08005]
 Cardiovascular peptides
  Angiotensin
   C02135  Angiotensin II
BRITE hierarchy
Other DBs
CAS: 11128-99-7 1407-47-2
PubChem: 5214
ChEBI: 2719
ChEMBL: CHEMBL408403
3DMET: B04840
NIKKAJI: J240.229G
KCF data Show

ATOM        75
            1   C1y C    32.6389  -18.4149
            2   N1y N    31.2954  -18.4149
            3   C1x C    30.8804  -19.6926
            4   C1x C    31.9672  -20.4823
            5   C1x C    33.0542  -19.6926
            6   C5a C    33.8024  -17.7432
            7   N1b N    34.9659  -18.4149
            8   C1c C    36.1293  -17.7432
            9   C1b C    37.2928  -18.4149
            10  O5a O    33.8024  -16.3998
            11  C6a C    36.1293  -16.3998
            12  O6a O    37.2948  -15.7269
            13  O6a O    34.9678  -15.7292
            14  C8y C    38.4588  -17.7417
            15  C8x C    39.6242  -18.4146
            16  C8x C    40.7877  -17.7429
            17  C8x C    40.7877  -16.3994
            18  C8x C    39.6223  -15.7265
            19  C8x C    38.4588  -16.3983
            20  C5a C    30.1320  -17.7432
            21  C1c C    28.9686  -18.4149
            22  N1b N    27.8052  -17.7432
            23  C5a C    26.6417  -18.4149
            24  C1c C    25.4782  -17.7432
            25  N1b N    24.3149  -18.4149
            26  C5a C    23.1513  -17.7432
            27  O5a O    30.1320  -16.3998
            28  C1b C    28.9686  -21.8179
            29  C8y C    30.1356  -22.4916
            30  C8x C    30.2763  -23.8301
            31  N5x N    31.5926  -24.1100
            32  C8x C    32.2656  -22.9445
            33  N4x N    31.3650  -21.9444
            34  O5a O    26.6417  -19.7618
            35  C1c C    25.4782  -15.7190
            36  C1b C    26.6433  -15.0463
            37  C1a C    24.3157  -15.0478
            38  C1a C    26.6433  -13.7031
            39  C1c C    21.9555  -18.4338
            40  O5a O    23.1512  -16.3854
            41  N1b N    20.7704  -17.7498
            42  C5a C    19.5915  -18.4283
            43  C1c C    18.4120  -17.7473
            44  N1b N    17.2326  -18.4283
            45  C5a C    16.0531  -17.7473
            46  C1c C    14.8735  -18.4283
            47  N1b N    13.6940  -17.7473
            48  C5a C    12.5145  -18.4283
            49  O5a O    19.5906  -19.7902
            50  C1c C    18.4120  -15.8386
            51  C1a C    17.2313  -15.1568
            52  C1a C    19.5902  -15.1584
            53  O5a O    16.0531  -16.3853
            54  C1c C    11.3329  -17.7461
            55  O5a O    12.5145  -19.7934
            56  C1b C    10.1492  -18.4296
            57  N1a N    11.3329  -16.3875
            58  C6a C     8.9700  -17.7488
            59  O6a O     7.7886  -18.4309
            60  O6a O     8.9701  -16.3875
            61  C1b C    14.8736  -19.7934
            62  C1b C    16.0522  -20.4738
            63  C1b C    16.0520  -21.8380
            64  N1b N    17.2310  -22.5206
            65  C2c C    17.2294  -23.8830
            66  N1a N    18.4084  -24.5656
            67  N2a N    16.0530  -24.5603
            68  C1b C    21.9556  -20.1360
            69  C8y C    23.1370  -20.8179
            70  C8x C    23.1371  -22.1796
            71  C8x C    24.3170  -22.8607
            72  C8y C    25.4969  -22.1794
            73  C8x C    25.4967  -20.8177
            74  C8x C    24.3167  -20.1366
            75  O1a O    26.6941  -22.8707
BOND        78
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     1   6 1 #Down
            7     6   7 1
            8     7   8 1
            9     8   9 1
            10    6  10 2
            11    8  11 1 #Down
            12   11  12 1
            13   11  13 2
            14    9  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   14  19 1
            21    2  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1 #Up
            27   25  26 1
            28   20  27 2
            29   21  28 1 #Down
            30   28  29 1
            31   29  30 2
            32   30  31 1
            33   31  32 2
            34   32  33 1
            35   29  33 1
            36   23  34 2
            37   24  35 1
            38   35  36 1
            39   35  37 1 #Up
            40   36  38 1
            41   26  39 1
            42   26  40 2
            43   39  41 1 #Down
            44   41  42 1
            45   42  43 1
            46   43  44 1 #Up
            47   44  45 1
            48   46  45 1 #Down
            49   46  47 1
            50   47  48 1
            51   42  49 2
            52   43  50 1
            53   50  51 1
            54   50  52 1
            55   45  53 2
            56   48  54 1
            57   48  55 2
            58   54  56 1
            59   54  57 1 #Down
            60   56  58 1
            61   58  59 1
            62   58  60 2
            63   46  61 1
            64   61  62 1
            65   62  63 1
            66   63  64 1
            67   64  65 1
            68   65  66 1
            69   65  67 2
            70   39  68 1
            71   68  69 1
            72   69  70 2
            73   70  71 1
            74   71  72 2
            75   72  73 1
            76   73  74 2
            77   69  74 1
            78   72  75 1

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