KEGG   COMPOUND: C07072
Entry
C07072                      Compound                               
Name
Losartan
Formula
C22H23ClN6O
Exact mass
422.1622
Mol weight
422.91
Structure
Remark
Same as: D08146
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09C ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN
    C09CA Angiotensin II receptor blockers (ARBs), plain
     C09CA01 Losartan
      D08146  Losartan (INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01495  Angiotensin II receptor antagonist
    DG00348  Losartan
     D08146  Losartan
  DG03231  Antihypertensive
   DG01495  Angiotensin II receptor antagonist
    DG00348  Losartan
     D08146  Losartan
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   DG00348  Losartan
    D08146  Losartan
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    AGTR1
     D08146  Losartan (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08146
Other DBs
CAS: 114798-26-4
PubChem: 9283
ChEBI: 6541
PDB-CCD: LSN[PDBj]
NIKKAJI: J276.444J
KCF data

ATOM        30
            1   N4y N    28.1559  -17.4542
            2   C8y C    28.5926  -18.7817
            3   C8y C    29.2912  -16.6217
            4   C1b C    26.9333  -16.7672
            5   N5x N    29.9898  -18.7817
            6   C1b C    27.7659  -19.9170
            7   C8y C    30.4265  -17.4542
            8   C1b C    29.2912  -15.2244
            9   C8y C    25.7339  -17.4892
            10  C1b C    28.3423  -21.1978
            11  X   Cl   31.7599  -17.0234
            12  O1a O    30.5023  -14.5256
            13  C8x C    25.7572  -18.8923
            14  C8x C    24.5054  -16.8079
            15  C1b C    27.5155  -22.3215
            16  C8x C    24.5520  -19.6085
            17  C8x C    23.2828  -17.5765
            18  C1a C    28.0919  -23.6024
            19  C8y C    23.3411  -18.9272
            20  C8y C    22.1358  -19.6433
            21  C8y C    20.9073  -18.9679
            22  C8x C    22.0892  -21.0406
            23  C8y C    20.9307  -17.5648
            24  C8x C    19.6439  -19.6841
            25  C8x C    20.9597  -21.7626
            26  N4x N    19.8012  -16.7613
            27  N5x N    22.0603  -16.7206
            28  C8x C    19.6963  -21.1339
            29  N5x N    20.2088  -15.4222
            30  N5x N    21.6061  -15.3989
BOND        33
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     6  10 1
            10    7  11 1
            11    8  12 1
            12    9  13 2
            13    9  14 1
            14   10  15 1
            15   13  16 1
            16   14  17 2
            17   15  18 1
            18   16  19 2
            19   19  20 1
            20   20  21 1
            21   20  22 2
            22   21  23 1
            23   21  24 2
            24   22  25 1
            25   23  26 1
            26   23  27 2
            27   24  28 1
            28   26  29 1
            29   27  30 1
            30    5   7 1
            31   17  19 1
            32   25  28 2
            33   29  30 2

» Japanese version

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Drug (1)   
   KEGG DRUG (1)   
Chemical substance (11)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   MASSBANK (6)   
   NIKKAJI (1)   
   PDB-CCD (1)   
All databases (12)   

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