KEGG   COMPOUND: C07502Help
Entry
C07502                      Compound                               

Name
Topiramate
Formula
C12H21NO8S
Exact mass
339.0988
Mol weight
339.362
Structure
Mol fileKCF fileDB search
Remark
Same as: D00537
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX11 Topiramate
      D00537  Topiramate (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Glutamate Reducing Agents
   Topiramate
    D00537  Topiramate (JAN/USAN/INN)
 Antimigraine Agents
  Prophylactic
   Topiramate
    D00537  Topiramate (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00537  Topiramate (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00537  Topiramate (JAN/USAN/INN) <JP/US>
   Glutamate (ionotropic), non-NMDA
    GRIA
     D00537  Topiramate (JAN/USAN/INN) <JP/US>
    GRIK
     D00537  Topiramate (JAN/USAN/INN) <JP/US>
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00537  Topiramate (JAN/USAN/INN) <JP/US>
    SCN2A
     D00537  Topiramate (JAN/USAN/INN) <JP/US>
    SCN3A
     D00537  Topiramate (JAN/USAN/INN) <JP/US>
    SCN4A
     D00537  Topiramate (JAN/USAN/INN) <JP/US>
    SCN5A
     D00537  Topiramate (JAN/USAN/INN) <JP/US>
    SCN8A
     D00537  Topiramate (JAN/USAN/INN) <JP/US>
    SCN9A
     D00537  Topiramate (JAN/USAN/INN) <JP/US>
    SCN10A
     D00537  Topiramate (JAN/USAN/INN) <JP/US>
    SCN11A
     D00537  Topiramate (JAN/USAN/INN) <JP/US>
   Calcium channels
    CACNA1-L
     D00537  Topiramate (JAN/USAN/INN) <JP/US>
 Enzymes
  Lyases (EC4)
   Aldehyde-lyases
    CA2
     D00537  Topiramate (JAN/USAN/INN) <JP/US>
    CA4
     D00537  Topiramate (JAN/USAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Neurological agents
  D00537
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00537
BRITE hierarchy
Other DBs
CAS: 97240-79-4
PubChem: 9705
ChEBI: 63631
ChEMBL: CHEMBL220492
PDB-CCD: TOR[PDBj]
NIKKAJI: J345.989F
KCF data Show

ATOM        22
            1   C1z C    25.3309  -17.5267
            2   C1y C    24.1301  -18.2229
            3   O2x O    26.3691  -18.4490
            4   O2x O    25.3309  -16.1287
            5   C1y C    22.9236  -17.5267
            6   O2x O    24.4261  -19.5802
            7   C1z C    25.9517  -19.7949
            8   C1x C    24.1242  -15.4269
            9   C1y C    22.9178  -16.1287
            10  O2x O    21.5952  -17.9559
            11  O2x O    21.5894  -15.6996
            12  C1z C    20.7716  -16.8307
            13  C1a C    19.7739  -15.8271
            14  C1a C    19.7739  -17.8108
            15  C1b C    26.7114  -17.5267
            16  O2a O    27.4075  -16.3202
            17  S4a S    28.7937  -16.3202
            18  O3c O    28.7881  -17.7123
            19  C1a C    25.5910  -21.1411
            20  C1a C    27.3454  -19.7949
            21  O3c O    30.1874  -16.3202
            22  N1a N    28.7937  -14.9265
BOND        24
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     5  10 1
            10    9  11 1
            11   10  12 1
            12   12  13 1
            13   12  14 1
            14    6   7 1
            15    8   9 1
            16   11  12 1
            17   15  16 1
            18   16  17 1
            19   17  18 2
            20    1  15 1 #Down
            21    7  19 1
            22    7  20 1
            23   17  21 2
            24   17  22 1

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