KEGG   COMPOUND: C15643
Entry
C15643                      Compound                               

Name
Dexamethasone
Formula
C22H29FO5
Exact mass
392.1999
Mol weight
392.4611
Structure
Remark
Same as: D00292
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Dexamethasone
   D00292  Dexamethasone (JP17/USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Dexamethasone
    D00292  Dexamethasone (JP17/USP/INN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Dexamethasone
     D00292  Dexamethasone (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1315  Ophthalmic cortisones
     D00292  Dexamethasone (JP17/USP/INN)
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D00292  Dexamethasone (JP17/USP/INN)
  24  Hormones
   245  Adrenal hormone preparations
    2454  Fluorinated adrenocorticotropic hormones
     D00292  Dexamethasone (JP17/USP/INN)
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D00292  Dexamethasone (JP17/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00292  Dexamethasone (JP17/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Dexamethasone
    D00292  Dexamethasone (JP17/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Dexamethasone
    D00292  Dexamethasone (JP17/USP/INN)
Animal drugs in Japan [BR:br08331]
 95  Agents for external use
  953  Analgesics, anti-itchings, astringents and antiinflammatory agents
   9539  Other analgesics, anti-itchings, astringents and inflammatory agents
    C15643  Dexamethasone
 96  Agents affecting metabolism
  961  Hormone preparations (except agents for breeding and external use)
   9612  Adrenal hormone preparations
    C15643  Dexamethasone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00292  Dexamethasone (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00292  Dexamethasone
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00292
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00292
Topical steroids potency [br08317.html]
 Classification in Japan
  D00292
Other DBs
CAS: 50-02-2
PubChem: 17396633
ChEBI: 41879
ChEMBL: CHEMBL1698267 CHEMBL1723662 CHEMBL378081 CHEMBL384467
PDB-CCD: DEX[PDBj]
NIKKAJI: J1.356K
KCF data

ATOM        28
            1   C2x C    15.4700  -16.9400
            2   C5x C    15.4700  -18.3400
            3   C2x C    16.6824  -19.0400
            4   C2y C    17.8949  -18.3400
            5   C1z C    17.8949  -16.9400
            6   C2x C    16.6824  -16.2400
            7   C1x C    19.1073  -19.0400
            8   C1x C    20.3197  -18.3400
            9   C1y C    20.3197  -16.9400
            10  C1z C    19.1073  -16.2400
            11  C1y C    21.5322  -16.2400
            12  C1z C    21.5322  -14.8400
            13  C1x C    20.3197  -14.1400
            14  C1y C    19.1073  -14.8400
            15  C1x C    23.9570  -16.2400
            16  C1y C    23.9570  -14.8400
            17  C1z C    22.7446  -14.1400
            18  C5a C    22.7446  -12.2500
            19  C1b C    23.9611  -11.5477
            20  O5a O    21.5362  -11.5523
            21  O1a O    25.1586  -12.2392
            22  O1a O    23.7511  -13.1577
            23  C1a C    25.1566  -14.1473
            24  X   F    19.1073  -17.6400
            25  O5x O    14.2576  -19.0400
            26  C1a C    21.5322  -13.4400
            27  C1a C    17.8949  -15.5400
            28  O1a O    18.1174  -13.8501
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   15  16 1
            18   16  17 1
            19   12  17 1
            20   17  18 1
            21   18  19 1
            22   18  20 2
            23   19  21 1
            24   17  22 1 #Down
            25   16  23 1 #Down
            26   10  24 1 #Down
            27    2  25 2
            28   11  15 1
            29   12  26 1 #Up
            30    5  27 1 #Up
            31   14  28 1 #Up

» Japanese version

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