KEGG   COMPOUND: C20048Help
Entry
C20048                      Compound                               

Name
Apamine;
Apamin
Formula
C79H131N31O24S4
Exact mass
2025.8866
Mol weight
2027.3387
Structure
Mol fileKCF fileDB search
Sequence
Cys Asn Cys Lys Ala Pro Glu Thr Ala Leu Cys Ala Arg Arg Cys Gln
Gln His-NH2 (Disulfide bridge: 1-11; 3-15)
  Organism
Apis mellifera [AME:406135]
  Type
Peptide
Brite
Natural toxins [BR:br08009]
 Venoms
  Bee venoms
   Peptides
    C20048  Apamine
Target-based classification of compounds [BR:br08010]
 Ion channels
  Voltage-gated cation channels
   K+ channel, KCNN, KCa2-3.x (Small conductance)
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
     C20048  Apamine
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
     C20048  Apamine
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
     C20048  Apamine
BRITE hierarchy
Other DBs
CAS: 24345-16-2
PubChem: 135626514
KCF data Show

ATOM        138
            1   C1c C    19.4600  -27.4400
            2   C5a C    20.6724  -28.1400
            3   N1b N    21.8849  -27.4400
            4   C1c C    23.0973  -28.1400
            5   C5a C    24.3097  -27.4400
            6   N1b N    25.5222  -28.1400
            7   C1c C    26.7346  -27.4400
            8   C5a C    27.9470  -28.1400
            9   O5a O    20.6724  -29.5398
            10  C1b C    23.0973  -29.5400
            11  C5a C    24.3118  -30.2412
            12  O5a O    25.5083  -29.5502
            13  N1a N    24.3118  -31.6398
            14  N1a N    18.2476  -28.1400
            15  C1b C    19.4600  -26.0400
            16  S3a S    18.2476  -25.3400
            17  S3a S    17.5476  -24.1276
            18  C1b C    17.5476  -22.7276
            19  C1c C    18.7824  -22.0500
            20  N1b N    19.9949  -22.7500
            21  C5a C    21.2073  -22.0500
            22  C1c C    22.4197  -22.7500
            23  C5a C    18.7277  -20.6505
            24  O5a O    19.6922  -20.0896
            25  N1b N    17.5468  -19.9513
            26  C1c C    17.5468  -17.5013
            27  C5a C    18.7771  -16.7908
            28  C1a C    16.3513  -16.8110
            29  O5a O    19.9806  -17.4856
            30  N1b N    18.7771  -15.3908
            31  C1c C    21.2327  -14.5605
            32  C5a C    24.1078  -15.4606
            33  C1b C    21.2147  -13.1600
            34  C1b C    22.4295  -12.4641
            35  O5a O    21.2073  -20.7900
            36  N1b N    23.6173  -22.0585
            37  C5a C    24.8056  -22.7445
            38  C1b C    22.4197  -24.1499
            39  C1c C    21.1925  -24.8585
            40  C1a C    19.9896  -24.1640
            41  C1a C    21.1927  -26.2499
            42  C1c C    25.9964  -22.0569
            43  O5a O    24.8057  -24.1498
            44  N1b N    27.1860  -22.7437
            45  C1a C    25.9965  -20.6503
            46  C5a C    28.3762  -22.0565
            47  C1c C    33.4162  -23.0365
            48  O5a O    28.3762  -20.6565
            49  O5a O    24.3097  -26.0401
            50  N1b N    29.1466  -27.4473
            51  O5a O    27.9470  -29.5399
            52  C1c C    30.3359  -28.1340
            53  C5a C    31.5262  -27.4466
            54  N1b N    32.7161  -28.1336
            55  O5a O    31.5262  -26.0402
            56  C1b C    30.3361  -29.5398
            57  C1b C    31.5290  -30.2285
            58  C1b C    31.5292  -31.6397
            59  C1b C    32.7198  -32.3272
            60  N1a N    32.7200  -33.7397
            61  N1b N    34.6024  -22.3300
            62  C5a C    35.8149  -23.0300
            63  C1c C    37.0273  -22.3300
            64  C1c C    33.4162  -24.4365
            65  O1a O    32.1872  -25.1464
            66  C1a C    34.6061  -25.1235
            67  O5a O    35.8149  -24.2898
            68  N1b N    38.2418  -23.0312
            69  C5a C    39.4383  -22.3402
            70  C1y C    40.9751  -22.9553
            71  C1b C    37.0273  -20.9300
            72  C1b C    38.2418  -20.2288
            73  C6a C    38.2418  -18.8288
            74  O6a O    39.4373  -18.1384
            75  O6a O    37.0136  -18.1196
            76  O5a O    39.4383  -20.9402
            77  C1c C    33.9061  -27.4464
            78  C5a C    35.0962  -28.1335
            79  C1a C    33.9061  -26.0464
            80  O5a O    35.0962  -29.5335
            81  N1y N    40.9306  -24.3599
            82  C1x C    42.2516  -24.8360
            83  C1x C    43.1127  -23.7269
            84  C1x C    42.3239  -22.5652
            85  N1b N    25.2924  -14.7700
            86  C1c C    26.5049  -15.4700
            87  C5a C    27.7360  -14.7590
            88  C1b C    26.5050  -16.8698
            89  C1b C    25.3114  -17.5591
            90  C1b C    25.3114  -18.9591
            91  N1b N    24.1160  -19.6496
            92  C2c C    22.9377  -18.9697
            93  N1a N    21.7422  -19.6606
            94  N2a N    22.9373  -17.5702
            95  O5a O    24.1078  -16.8606
            96  N1b N    28.9412  -15.4547
            97  O5a O    27.7357  -13.3701
            98  C1c C    30.1235  -14.7719
            99  C5a C    30.1235  -13.3719
            100 N1b N    31.3190  -12.6815
            101 O5a O    28.8927  -12.6612
            102 C1b C    31.3174  -15.4613
            103 S3a S    31.3174  -16.8613
            104 S3a S    32.5299  -17.5613
            105 C1b C    32.5299  -18.9613
            106 C1c C    31.3190  -11.2815
            107 C5a C    32.5143  -10.5910
            108 N1b N    33.6924  -11.2700
            109 C1c C    34.9049  -10.5700
            110 C5a C    36.1173  -11.2700
            111 N1b N    37.3297  -10.5700
            112 C1c C    38.5422  -11.2700
            113 C1b C    30.0798  -10.5661
            114 C1b C    30.0798   -9.1661
            115 C5a C    28.8842   -8.4758
            116 O5a O    27.6937   -9.1633
            117 N1a N    28.8841   -7.0702
            118 O5a O    32.5141   -9.1704
            119 C1b C    34.9049   -9.1700
            120 C1b C    36.1360   -8.4590
            121 C5a C    36.1360   -7.0590
            122 N1a N    37.3317   -6.3687
            123 O5a O    34.9165   -6.3548
            124 O5a O    36.1173  -12.6700
            125 C1b C    39.7753  -10.5578
            126 C5a C    38.5423  -12.6697
            127 N1a N    39.7755  -13.3819
            128 O5a O    37.3507  -13.3580
            129 C8y C    40.9815  -11.2540
            130 C8x C    41.1296  -12.6584
            131 N5x N    42.5110  -12.9516
            132 C8x C    43.2167  -11.7284
            133 N4x N    42.2715  -10.6792
            134 C1b C    22.4295  -11.0641
            135 N1b N    23.6213  -10.3756
            136 C2c C    23.6213   -8.9756
            137 N1a N    24.8166   -8.2851
            138 N2a N    22.3785   -8.2583
BOND        141
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     7   8 1
            8     2   9 2
            9     4  10 1
            10   10  11 1
            11   11  12 2
            12   11  13 1
            13    1  14 1
            14    1  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 1
            21   21  22 1
            22   19  23 1
            23   23  24 2
            24   23  25 1
            25   25  26 1
            26   26  27 1
            27   26  28 1 #Up
            28   27  29 2
            29   27  30 1
            30   30  31 1
            31   31  32 1
            32   31  33 1
            33   33  34 1
            34   21  35 2
            35   22  36 1
            36   36  37 1
            37   22  38 1 #Up
            38   38  39 1
            39   39  40 1
            40   39  41 1
            41   37  42 1
            42   37  43 2
            43   42  44 1
            44   42  45 1
            45   44  46 1
            46   46  47 1
            47   46  48 2
            48    5  49 2
            49    8  50 1
            50    8  51 2
            51   50  52 1
            52   52  53 1
            53   53  54 1
            54   53  55 2
            55   52  56 1 #Down
            56   56  57 1
            57   57  58 1
            58   58  59 1
            59   59  60 1
            60   47  61 1
            61   61  62 1
            62   62  63 1
            63   47  64 1
            64   64  65 1
            65   64  66 1 #Down
            66   62  67 2
            67   63  68 1
            68   68  69 1
            69   69  70 1
            70   63  71 1 #Down
            71   71  72 1
            72   72  73 1
            73   73  74 1
            74   73  75 2
            75   69  76 2
            76   54  77 1
            77   77  78 1
            78   77  79 1 #Up
            79   78  80 2
            80   70  81 1
            81   81  82 1
            82   82  83 1
            83   83  84 1
            84   70  84 1
            85   78  81 1
            86   32  85 1
            87   85  86 1
            88   86  87 1
            89   86  88 1
            90   88  89 1
            91   89  90 1
            92   90  91 1
            93   91  92 1
            94   92  93 1
            95   92  94 2
            96   32  95 2
            97   87  96 1
            98   87  97 2
            99   96  98 1
            100  98  99 1
            101  99 100 1
            102  99 101 2
            103  98 102 1
            104 102 103 1
            105 103 104 1
            106 104 105 1
            107   7 105 1
            108 100 106 1
            109 106 107 1
            110 107 108 1
            111 108 109 1
            112 109 110 1
            113 110 111 1
            114 111 112 1
            115 106 113 1
            116 113 114 1
            117 114 115 1
            118 115 116 2
            119 115 117 1
            120 107 118 2
            121 109 119 1 #Up
            122 119 120 1
            123 120 121 1
            124 121 122 1
            125 121 123 2
            126 110 124 2
            127 112 125 1
            128 112 126 1 #Up
            129 126 127 1
            130 126 128 2
            131 125 129 1
            132 129 130 2
            133 130 131 1
            134 131 132 2
            135 132 133 1
            136 129 133 1
            137  34 134 1
            138 134 135 1
            139 135 136 1
            140 136 137 1
            141 136 138 2

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