KEGG T05350: 108227144

Daucus carota (carrot): 108227144

Entry

108227144         CDS       T05350

Name

(RefSeq) bifunctional dihydrofolate reductase-thymidylate synthase

K13998

dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]

Organism

dcr Daucus carota (carrot)

Pathway

dcr00240

Pyrimidine metabolism

dcr00670

One carbon pool by folate

dcr00790

Folate biosynthesis

dcr01100

Metabolic pathways

dcr01232

Nucleotide metabolism

dcr01240

Biosynthesis of cofactors

Module

dcr_M00126

Tetrahydrofolate biosynthesis, GTP => THF

dcr_M00938

Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP

Brite

KEGG Orthology (KO) [BR:dcr00001]
09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    108227144
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    108227144
   00670 One carbon pool by folate
    108227144
Enzymes [BR:dcr01000]
1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     108227144
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     108227144

SSDB

Motif

Pfam:

Thymidylat_synt DHFR_1

Other DBs

NCBI-GeneID:

108227144

NCBI-ProteinID:

XP_017257659

Position

1:41024381..41030038

AA seq 576 aa
MYKALISSTFPLLNSLSQTLALRSASLYLLTNCNLSSSNFSHCHRFTTYMASEALANPTN
GSGITRPDPQRTYQVVVAATQNMGIGKDGKLPWRLPSDMKFFKDVTMTTSDPLKRNAVIM
GRKTWESIPIQHRPLPGRLNVVLTRSGSFDIATVENVVICGSMISALELLAGSPYCVSVE
KVFVIGGGQIYREALNAPGCDAVHITEIEEHIECDTFIPLLDESVFQPWYSSFPLVENKI
RYCFTTYVRVRNSVAELTSQTNGLSSDSKSDSGNFEIQNFSFLPKTVFEKHEEYLYLGLV
ENIISNGVTKNDRTRTGTVSIFGCQMRFNLRKSFPLLTTKKVFWRGVVEELLWFISGSTN
AKILKEKGVNIWEGNGSREYLDSIGLTDREEGDLGPIYGFQWRHFGARYTDMHADYSGQG
FDQLLDVISKIKNNPDDRRIILSAWNPSDLRLMALPPCHMFAQFYVANGELSCQMYQRSA
DMGLGVPFNIASYALLTCMIAHVCDLVPGDFVHSIGDAHVYCNHVRPLRDQLQKLPKPFP
VLKINSEKRDIDSFEAADFKLIGYDPHQKIEMKMAV

NT seq 1731 nt +upstreamnt +downstreamnt
atgtataaagccctaatttcatccacatttcctcttctaaactcactttcacaaactttg
gctctccgatcggcttctttgtacttgcttaccaattgcaacttatcatcatcaaacttc
tctcattgccatcggtttactacatatatggctagcgaagctctcgcaaatcctactaat
ggaagtggcattacacgccctgatccacaaagaacttatcaggttgtggttgctgcaacc
caaaatatgggtatcggtaaggatggtaaattgccctggaggttaccttctgacatgaaa
tttttcaaggatgtcaccatgactacatcagatcctttgaaaaggaatgcagtcataatg
ggtaggaaaacttgggaaagtattcccattcaacatcgccctctgcccggacgtcttaat
gttgttttgactcgttctgggagttttgatattgcaactgtcgaaaatgtcgtaatatgt
ggtagcatgatttctgctttggaattattagcaggatctccttattgtgtttcagttgag
aaggtttttgtcattgggggtggccagatatatagggaagctctcaatgctcctggatgt
gatgcagtccacatcactgaaattgaagaacacatagaatgtgataccttcattcctctt
ctcgatgaatcagtttttcagccatggtactcatcattcccattggtggagaacaaaatt
cgttattgtttcacgacttatgttcgtgtgaggaattctgttgcggagctcacaagtcag
accaacggtctgtcatctgatagtaaatcagattctggtaattttgaaattcagaatttc
tcttttcttcccaagacagtttttgagaaacacgaggagtatttgtatctgggattggtt
gagaatatcatttctaatggtgtgacaaagaatgataggacacgtactggtactgtctct
atatttggttgccagatgcggtttaatttgcgcaaatcttttccactcctcacaactaag
aaagtgttttggaggggagttgttgaggaactactgtggttcattagtggctcaactaat
gctaagattctaaaagagaagggcgttaatatttgggaaggcaatggatcaagggagtat
cttgacagtattggtttgacggatagagaagaaggtgacttggggcctatatatggtttt
cagtggagacactttggtgcaaggtatactgatatgcatgctgactactcaggccaggga
tttgatcagttgctagatgttatttcaaagataaaaaataatcctgatgataggaggatc
attctatcagcttggaatccatctgatctcaggctaatggcacttccaccctgtcacatg
tttgcacagttctatgtagccaatggcgagttatcttgtcaaatgtatcagcgctctgct
gatatgggtctcggtgttccattcaacattgcatcatatgcacttttgacatgcatgatt
gctcatgtttgtgacctggttcctggagattttgttcattctattggtgatgctcatgtc
tactgcaaccatgtcagacctcttcgagaccagcttcagaagttgcctaagccatttccg
gttttgaagatcaattctgagaaaagggacattgactcatttgaggctgctgatttcaaa
ctcattggttatgatccgcaccagaaaatcgaaatgaaaatggcagtataa

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