KEGG   DGROUP: CYP2D6 substrateHelp
Entry
DG01644                     DGroup                                 

Name
CYP2D6 substrate
Member
D01131  
Lafutidine (JP17/INN)  <JP>
Metoclopramide
 D00726  
Metoclopramide (JP17/INN)  <JP>
 D02213  
Metoclopramide hydrochloride (JAN)  <JP>
 D05008  
Metoclopramide hydrochloride (USAN)  <US>
Ondansetron
 D00456  
Ondansetron (JAN/USP/INN)  <US>
 D00678  
Ondansetron hydrochloride hydrate (JAN/USP)  <JP/US>
Dolasetron
 D07867  
Dolasetron (INN)
 D00725  
Dolasetron mesylate (USP)  <US>
Palonosetron
 D07175  
Palonosetron (INN)
 D05343  
Palonosetron hydrochloride (JAN/USAN)  <JP/US>
Dexfenfluramine
 D07805  
Dexfenfluramine (INN)
 D03713  
Dexfenfluramine hydrochloride (USAN)
Phenformin
 D08351  
Phenformin (BAN)
 D08352  
Phenformin hydrochloride
Eliglustat
 D09893  
Eliglustat (USAN/INN)
 D09894  
Eliglustat tartrate (JAN/USAN)  <JP/US>
D01896  
Cilostazol (JP17/USAN/INN)  <JP/US>
Sparteine
 D01041  
Sparteine (INN)
 D02239  
Sparteine sulfate (JAN/USAN)
D00199  
Ajmaline (JP17)
Mexiletine
 D08215  
Mexiletine (INN)
 D00639  
Mexiletine hydrochloride (JP17/USP)  <JP/US>
Aprindine
 D02969  
Aprindine (USAN/INN)
 D01326  
Aprindine hydrochloride (JP17/USAN)  <JP>
Propafenone
 D08435  
Propafenone (INN)
 D00640  
Propafenone hydrochloride (JP17/USP)  <JP/US>
Flecainide
 D07962  
Flecainide (INN)
 D00638  
Flecainide acetate (JP17/USP)  <JP/US>
Encainide
 D07894  
Encainide (INN)
 D03991  
Encainide hydrochloride (USAN)
Cibenzoline
 D03492  
Cifenline (USAN); Cibenzoline (INN)
 D01455  
Cifenline succinate (USAN); Cibenzoline succinate (JP17)  <JP>
Urapidil
 D01333  
Urapidil (JP17/INN)  <JP>
 D08662  
Urapidil hydrochloride
D03664  
Debrisoquin sulfate (USAN)
Alprenolol
 D07156  
Alprenolol (INN)
 D01182  
Alprenolol hydrochloride (JP17/USAN)
D00513  
Pindolol (JP17/USP/INN)  <JP/US>
Propranolol
 D08443  
Propranolol (INN)
 D00483  
Propranolol hydrochloride (JP17/USP)  <JP/US>
Timolol
 D08600  
Timolol (INN)
 D00378  
Timolol (USAN)  <US>
 D00603  
Timolol maleate (JP17/USP)  <JP/US>
Carteolol
 D07624  
Carteolol (INN)
 D00599  
Carteolol hydrochloride (JP17/USP)  <JP/US>
Bopindolol
 D07537  
Bopindolol (INN)
 D01794  
Bopindolol malonate (JAN)
Metoprolol
 D02358  
Metoprolol (USAN/INN)
 D00601  
Metoprolol tartrate (JP17/USP)  <JP/US>
 D00635  
Metoprolol succinate (USP)  <US>
 D05011  
Metoprolol fumarate (USP)
D00235  
Atenolol (JP17/USP/INN)  <JP/US>
Nebivolol
 D05127  
Nebivolol (USAN/INN)
 D06622  
Nebivolol hydrochloride (USAN)  <US>
Carvedilol
 D00255  
Carvedilol (JP17/USAN/INN)  <JP/US>
 D03415  
Carvedilol phosphate (USAN); Carvedilol phosphate hydrate (JAN)  <US>
Bepridil
 D07520  
Bepridil (INN)
 D00631  
Bepridil hydrochloride (USAN); Bepridil hydrochloride hydrate (JAN)  <JP>
Perhexiline
 D08340  
Perhexiline (INN)
 D05442  
Perhexiline maleate (USAN)
Promethazine
 D00494  
Promethazine (JAN/INN)
 D00480  
Promethazine hydrochloride (JP17/USP)  <JP/US>
 D01242  
Promethazine teoclate (JAN/INN)
 D03290  
Promethazine methylenedisalicylate (JAN)  <JP>
 D08432  
Promethazine maleate
 D08768  
Promethazine hibenzate  <JP>
Doxepin
 D07875  
Doxepin (INN)
 D00814  
Doxepin hydrochloride (USP)  <US>
Tolterodine
 D00646  
Tolterodine (USAN/INN)
 D01148  
Tolterodine tartrate (JAN/USAN)  <JP/US>
Darifenacin
 D03654  
Darifenacin (USAN/INN)
 D01699  
Darifenacin hydrobromide (JAN/USAN)  <US>
Fesoterodine
 D07226  
Fesoterodine (INN)
 D08923  
Fesoterodine fumarate (JAN/USP)  <JP/US>
D11389  
Dutasteride and tamsulosin  <US>
D01078  
Telithromycin (JAN/USAN/INN)
D09785  
Delamanid (JAN/USAN)  <JP>
D00427  
Ritonavir (JAN/USAN/INN)  <JP/US>
D00435  
Nevirapine (JAN/USP/INN)  <JP/US>
Tamoxifen
 D08559  
Tamoxifen (INN)
 D00966  
Tamoxifen citrate (JP17/USP)  <JP/US>
D01583  
Pirfenidone (JAN/USAN/INN)  <JP/US>
Oxycodone
 D05312  
Oxycodone (USAN/INN)
 D00847  
Oxycodone hydrochloride (USP)  <US>
 D02175  
Compound oxycodone (JP17)
 D03783  
Oxycodone terephthalate (USP)
 D05462  
Oxycodone hydrochloride hydrate (JP17)  <JP>
Dihydrocodeine
 D07831  
Dihydrocodeine (INN)
 D01481  
Dihydrocodeine phosphate (JP17)  <JP>
 D03825  
Dihydrocodeine bitartrate (USP)
 D07832  
Dihydrocodeine thiocyanate
D08695  
dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea  <JP>
D09999  
Tramadol hydrochloride and acetaminophen  <JP/US>
Tramadol
 D08623  
Tramadol (INN)
 D01355  
Tramadol hydrochloride (JP17/USAN)  <JP/US>
D11573  
Oxycodone and ibuprofen  <US>
Naratriptan
 D08255  
Naratriptan (INN)
 D00674  
Naratriptan hydrochloride (JAN/USP)  <JP/US>
Almotriptan
 D02824  
Almotriptan (USAN)
 D02825  
Almotriptan malate (USAN)  <US>
Selegiline
 D03731  
Selegiline (USAN/INN)  <US>
 D00785  
Selegiline hydrochloride (JAN/USP)  <JP/US>
Chlorpromazine
 D00270  
Chlorpromazine (USP/INN)
 D00789  
Chlorpromazine hydrochloride (JP17/USP)  <JP/US>
 D03274  
Chlorpromazine hibenzate (JAN)
 D04034  
Chlorpromazine phenolphthalinate (JAN)  <JP>
 D09819  
Chlorpromazine tannate (JAN)
Fluphenazine
 D07977  
Fluphenazine (INN)
 D00791  
Fluphenazine hydrochloride (JAN/USP)  <US>
 D00792  
Fluphenazine enanthate (JP17/USP)
 D00793  
Fluphenazine decanoate (JAN/USP)  <JP/US>
 D02163  
Fluphenazine maleate (JAN)  <JP>
Perphenazine
 D00503  
Perphenazine (JP17/USP/INN)  <JP/US>
 D02037  
Perphenazine maleate (JP17)  <JP>
 D04038  
Perphenazine fendizoate (JAN)  <JP>
 D04965  
Perphenazine hydrochloride  <JP>
 D08341  
Perphenazine decanoate
 D08342  
Perphenazine enantate
Haloperidol
 D00136  
Haloperidol (JP17/USP/INN)  <JP/US>
 D01898  
Haloperidol decanoate (JAN/USAN)  <JP/US>
 D08035  
Haloperidol lactate  <US>
Zuclopenthixol
 D03556  
Zuclopenthixol (INN)
 D08691  
Zuclopenthixol acetate
 D08692  
Zuclopenthixol decanoate
 D08693  
Zuclopenthixol dihydrochloride
D00560  
Pimozide (JP17/USP/INN)  <JP/US>
Loxapine
 D02340  
Loxapine (USAN/INN)
 D00794  
Loxapine succinate (USP)  <US>
 D08148  
Loxapine hydrochloride
Olanzapine
 D00454  
Olanzapine (JAN/USP/INN)  <JP/US>
 D06623  
Olanzapine pamoate (USAN)  <US>
D00426  
Risperidone (JP17/USAN/INN)  <JP/US>
Aripiprazole
 D01164  
Aripiprazole (JAN/USAN/INN)  <JP/US>
 D10355  
Aripiprazole cavoxil (USAN)
 D10364  
Aripiprazole lauroxil (USAN)  <US>
 D10516  
Aripiprazole hydrate (JAN)  <JP/US>
D02666  
Iloperidone (USAN/INN)  <US>
Cariprazine
 D09997  
Cariprazine (USAN/INN)
 D09876  
Cariprazine hydrochloride (JAN/USAN)  <US>
D10309  
Brexpiprazole (JAN/USAN/INN)  <JP/US>
D08969  
Pimavanserin tartrate (USAN)  <US>
D02615  
Chlorpromazine hydrochloride, promethazine hydrochloride and phenobarbital
Dexmedetomidine
 D00514  
Dexmedetomidine (USAN/INN)
 D01205  
Dexmedetomidine hydrochloride (JAN/USAN)  <JP/US>
Imipramine
 D08070  
Imipramine (INN)
 D00815  
Imipramine hydrochloride (JP17/USP)  <JP/US>
 D08071  
Imipramine pamoate (USP)  <US>
Clomipramine
 D07727  
Clomipramine (INN)
 D00811  
Clomipramine hydrochloride (JP17/USP)  <JP/US>
Amitriptyline
 D07448  
Amitriptyline (INN)
 D00809  
Amitriptyline hydrochloride (JP17/USP)  <JP/US>
Nortriptyline
 D08288  
Nortriptyline (INN)
 D00816  
Nortriptyline hydrochloride (JP17/USP/INN)  <JP/US>
Dosulepin
 D07872  
Dosulepin (INN)
 D01546  
Dothiepin hydrochloride (USAN); Dosulepin hydrochloride (JAN)  <JP>
D00228  
Amoxapine (JP17/USP/INN)  <JP/US>
Maprotiline
 D02566  
Maprotiline (USAN)
 D00818  
Maprotiline hydrochloride (JP17/USP)  <JP/US>
Fluoxetine
 D00326  
Fluoxetine (USAN/INN)
 D00823  
Fluoxetine hydrochloride (JAN/USP)  <US>
Citalopram
 D07704  
Citalopram (USP/INN)
 D00822  
Citalopram hydrobromide (USAN)  <US>
 D07705  
Citalopram hydrochloride
Paroxetine
 D02362  
Paroxetine (USP/INN)
 D02260  
Paroxetine hydrochloride hydrate (JP17)  <JP/US>
 D05374  
Paroxetine hydrochloride (USP)  <US>
 D05375  
Paroxetine mesylate (USAN)  <US>
Fluvoxamine
 D07984  
Fluvoxamine (INN)
 D00824  
Fluvoxamine maleate (JP17/USAN)  <JP/US>
Escitalopram
 D07913  
Escitalopram (INN)
 D02567  
Escitalopram oxalate (JAN/USAN)  <JP/US>
Mianserin
 D08216  
Mianserin (INN)
 D01358  
Mianserin hydrochloride (JAN/USAN)  <JP>
Trazodone
 D08626  
Trazodone (INN)
 D00820  
Trazodone hydrochloride (JAN/USP)  <JP/US>
Minaprine
 D05039  
Minaprine (USAN/INN)
 D05040  
Minaprine hydrochloride (USAN)
Mirtazapine
 D00563  
Mirtazapine (JAN/USAN/INN)  <JP/US>
 D11056  
Mirtazapine hydrate (JAN)
Venlafaxine
 D08670  
Venlafaxine (INN)
 D00821  
Venlafaxine hydrochloride (JAN/USAN)  <JP/US>
Duloxetine
 D07880  
Duloxetine (INN)
 D01179  
Duloxetine hydrochloride (JAN/USP)  <JP/US>
Vilazodone
 D09698  
Vilazodone (USAN/INN)
 D09699  
Vilazodone hydrochloride (USAN)  <US>
Vortioxetine
 D10184  
Vortioxetine (USAN)
 D10185  
Vortioxetine hydrobromide (JAN/USAN)  <JP/US>
Amfetamine
 D07445  
Amfetamine (INN)  <US>
 D02074  
Amphetamine sulfate (USP)  <US>
Metamfetamine
 D08187  
Metamfetamine (INN)
 D02242  
Methamphetamine hydrochloride (JP17/USP)  <JP/US>
Atomoxetine
 D07473  
Atomoxetine (USP/INN)
 D02574  
Atomoxetine hydrochloride (JAN/USP)  <JP/US>
Donepezil
 D07869  
Donepezil (INN)
 D00670  
Donepezil hydrochloride (JP17/USAN)  <JP/US>
Galantamine
 D04292  
Galantamine (USAN/INN)
 D02173  
Galantamine hydrobromide (JAN/USAN)  <JP/US>
Cevimeline
 D07667  
Cevimeline (INN)
 D00661  
Cevimeline hydrochloride (USAN); Cevimeline hydrochloride hydrate (JAN)  <JP/US>
Methadone
 D08195  
Methadone (BAN)
 D02102  
Methadone hydrochloride (JAN/USP)  <JP/US>
Cinnarizine
 D01295  
Cinnarizine (JAN/USAN/INN)
 D07734  
Cinnarizine dihydrochloride
Flunarizine
 D07971  
Flunarizine (INN)
 D01303  
Flunarizine hydrochloride (JAN/USAN)
D08575  
Tetrabenazine (JAN/INN)  <JP/US>
D10533  
Umeclidinium bromide and vilanterol  <JP/US>
Umeclidinium
 D10180  
Umeclidinium (USAN)
 D10181  
Umeclidinium bromide (JAN/USAN)  <JP/US>
Hydrocodone
 D08045  
Hydrocodone (INN)
 D03725  
Hydrocodone bitartrate (USP)  <US>
 D04461  
Hydrocodone polistirex (USAN)
 D08046  
Hydrocodone hydrochloride
Codeine
 C06174  
Codeine
 D00195  
Codeine (USP)
 D02101  
Codeine phosphate (USP); Codeine phosphate hydrate (JP17)  <JP>
 D03579  
Codeine polistirex (USAN)
 D03580  
Codeine sulfate (USP)  <US>
 D07740  
Codeine hydrochloride
Dextromethorphan
 D03742  
Dextromethorphan (USP)
 D00848  
Dextromethorphan hydrobromide (USP); Dextromethorphan hydrobromide hydrate (JP17)  <JP>
 D03744  
Dextromethorphan polistirex (USAN)
D04340  
Dextromethorphan hydrobromide and potassium cresolsulfonate  <JP>
Dexchlorpheniramine
 D07803  
Dexchlorpheniramine (INN)
 D00668  
Dexchlorpheniramine maleate (USP); d-Chlorpheniramine maleate (JP17)  <JP/US>
D04313  
Dihydrocodeine phosphate, dl-methylephedrine hydrochloride and Chlorpheniramine maleate  <JP>
D01324  
Mequitazine (JP17/INN)  <JP>
D00364  
Loratadine (JAN/USAN/INN)  <JP/US>
D10512  
Brinzolamide and timolol maleate  <JP>
D08493  
Dorzolamide hydrochloride and timolol maleate  <JP/US>
D09881  
Cobicistat (JAN/USAN/INN)  <US>
Trelagliptin
 D10178  
Trelagliptin (USAN)
 D10179  
Trelagliptin succinate (JAN/USAN)  <JP>
Ramosetron
 D08466  
Ramosetron (INN)
 D02016  
Ramosetron hydrochloride (JAN)  <JP>
Sarpogrelate
 D08508  
Sarpogrelate (INN)
 D01624  
Sarpogrelate hydrochloride (JP17)  <JP>
Benzhydrocodone
 D10612  
Benzhydrocodone (USAN/INN)
 D10692  
Benzhydrocodone hydrochloride (USAN)
Pitolisant
 D10749  
Pitolisant (USAN/INN)
 D11490  
Pitolisant hydrochloride (USAN)
D01444  
Bunitrolol hydrochloride (JAN)
D04338  
Dihydrocodeine phosphate, ephedrine hydrochloride and ammmonium chloride  <JP>
D08697  
Platycodon fluidextract, glycyrrhiza extract, plantago herb extract, peony root extract and dihydrocodeine phosphate  <JP>
D10466  
Vonoprazan fumarate (JAN)  <JP>
D10774  
Vonoprazan, amoxicillin and metronidazole  <JP>
D10775  
Vonoprazan, amoxicillin and clarithromycin  <JP>
D11628  
Benzhydrocodone and acetaminophen  <US>
 » expand
Class
Metabolizing enzyme substrate

» Japanese version

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