KEGG   PATHWAY: dme00790
Entry
dme00790                    Pathway                                
Name
Folate biosynthesis - Drosophila melanogaster (fruit fly)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
dme00790  Folate biosynthesis
dme00790

Module
dme_M00842  Tetrahydrobiopterin biosynthesis, GTP => BH4 [PATH:dme00790]
dme_M00880  Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:dme00790]
Other DBs
GO: 0046656
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG9441  Pu; punch, isoform A [KO:K01495] [EC:3.5.4.16]
Dmel_CG3264  Alp8; alkaline phosphatase 8, isoform B [KO:K01077] [EC:3.1.3.1]
Dmel_CG3290  Alp2; alkaline phosphatase 2 [KO:K01077] [EC:3.1.3.1]
Dmel_CG3292  Alp7; alkaline phosphatase 7 [KO:K01077] [EC:3.1.3.1]
Dmel_CG8105  Alp11; alkaline phosphatase 11 [KO:K01077] [EC:3.1.3.1]
Dmel_CG10827  Alp5; alkaline phosphatase 5 [KO:K01077] [EC:3.1.3.1]
Dmel_CG1809  Alp6; alkaline phosphatase 6 [KO:K01077] [EC:3.1.3.1]
Dmel_CG16771  Alp12; alkaline phosphatase 12, isoform B [KO:K01077] [EC:3.1.3.1]
Dmel_CG10592  Alp10; alkaline phosphatase 10 [KO:K01077] [EC:3.1.3.1]
Dmel_CG5150  Alp9; alkaline phosphatase 9, isoform B [KO:K01077] [EC:3.1.3.1]
Dmel_CG5656  Alp1; alkaline phosphatase 1, isoform B [KO:K01077] [EC:3.1.3.1]
Dmel_CG8147  phu; phurba tashi [KO:K01077] [EC:3.1.3.1]
Dmel_CG1462  Alp4; alkaline phosphatase 4, isoform A [KO:K01077] [EC:3.1.3.1]
Dmel_CG5361  Alp13; alkaline phosphatase 13 [KO:K01077] [EC:3.1.3.1]
Dmel_CG14887  Dhfr; dihydrofolate reductase, isoform B [KO:K00287] [EC:1.5.1.3]
Dmel_CG2543  Fpgs1; folylpolyglutamate synthase 1, isoform B [KO:K01930] [EC:6.3.2.17]
Dmel_CG31773  Fpgs2; folylpolyglutamate synthase 2 [KO:K01930] [EC:6.3.2.17]
Dmel_CG32155  l(3)72Dp; lethal (3) 72Dp [KO:K01307] [EC:3.4.19.9]
Dmel_CG16784  pr; purple [KO:K01737] [EC:4.2.3.12 4.1.2.50]
Dmel_CG12117  Sptr; sepiapterin reductase [KO:K00072] [EC:1.1.1.153]
Dmel_CG12116  CG12116; uncharacterized protein [KO:K00072] [EC:1.1.1.153]
Dmel_CG6084  Akr1B; Aldo-keto reductase 1B, isoform C [KO:K00011] [EC:1.1.1.21]
Dmel_CG12766  CG12766; uncharacterized protein [KO:K00011] [EC:1.1.1.21]
Dmel_CG10863  CG10863; uncharacterized protein [KO:K00011] [EC:1.1.1.21]
Dmel_CG9436  CG9436; uncharacterized protein [KO:K00011] [EC:1.1.1.21]
Dmel_CG6083  CG6083; uncharacterized protein [KO:K00011] [EC:1.1.1.21]
Dmel_CG10638  CG10638; uncharacterized protein, isoform D [KO:K00011] [EC:1.1.1.21]
Dmel_CG40064  ARY; Aldo-keto reductase on Y, isoform C [KO:K00011] [EC:1.1.1.21]
Dmel_CG4665  Dhpr; dihydropteridine reductase, isoform B [KO:K00357] [EC:1.5.1.34]
Dmel_CG1963  Pcd; pterin-4a-carbinolamine dehydratase [KO:K01724] [EC:4.2.1.96]
Dmel_CG7399  Hn; henna, isoform C [KO:K00500] [EC:1.14.16.1]
Dmel_CG10118  ple; pale, isoform C [KO:K00501] [EC:1.14.16.2]
Dmel_CG9122  Trhn; tryptophan hydroxylase neuronal [KO:K00502] [EC:1.14.16.4]
Dmel_CG6781  se; sepia [KO:K00310] [EC:1.5.4.1]
Dmel_CG6776  GstO3; glutathione S transferase O3 [KO:K00310] [EC:1.5.4.1]
Dmel_CG6673  GstO2; glutathione S transferase O2, isoform B [KO:K00310] [EC:1.5.4.1]
Dmel_CG33048  Mocs1; molybdenum cofactor synthesis 1, isoform C [KO:K20967] [EC:4.1.99.22 4.6.1.17]
Dmel_CG10238  Mocs2B; molybdenum cofactor synthesis 2B [KO:K03635] [EC:2.8.1.12]
Dmel_CG2945  cin; cinnamon, isoform A [KO:K15376] [EC:2.10.1.1 2.7.7.75]
Dmel_CG1692  mal; maroon-like, isoform B [KO:K15631] [EC:2.8.1.9]
Compound
C00044  GTP
C00101  Tetrahydrofolate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00156  4-Hydroxybenzoate
C00251  Chorismate
C00266  Glycolaldehyde
C00268  Dihydrobiopterin
C00272  Tetrahydrobiopterin
C00415  Dihydrofolate
C00504  Folate
C00568  4-Aminobenzoate
C00835  Sepiapterin
C00921  Dihydropteroate
C01217  5,6,7,8-Tetrahydromethanopterin
C01300  6-(Hydroxymethyl)-7,8-dihydropterin
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C02587  Pyrimidodiazepine
C02953  7,8-Dihydrobiopterin
C03541  THF-polyglutamate
C03684  6-Pyruvoyltetrahydropterin
C04244  6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  6-Hydroxymethyl-7,8-dihydropterin diphosphate
C04874  7,8-Dihydroneopterin
C04895  7,8-Dihydroneopterin 3'-triphosphate
C05922  Formamidopyrimidine nucleoside triphosphate
C05923  2,5-Diaminopyrimidine nucleoside triphosphate
C05924  Molybdopterin
C05925  Dihydroneopterin phosphate
C05926  Neopterin
C05927  7,8-Dihydromethanopterin
C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C06313  Biopterin
C09332  THF-L-glutamate
C11355  4-Amino-4-deoxychorismate
C15522  4a-Hydroxytetrahydrobiopterin
C15996  7-Cyano-7-carbaguanine
C16675  7-Aminomethyl-7-carbaguanine
C18237  Molybdoenzyme molybdenum cofactor
C18239  Precursor Z
C18802  Tetrahydrosarcinapterin
C19848  Adenylated molybdopterin
C19871  Guanylyl molybdenum cofactor
C20239  6-Carboxy-5,6,7,8-tetrahydropterin
C20248  7-Carboxy-7-carbaguanine
C20264  L-threo-Tetrahydrobiopterin
C20559  4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
C20562  N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
C20566  7,8-Dihydroneopterin 2'-phosphate
C20567  7,8-Dihydroneopterin 2',3'-cyclic phosphate
C21007  5,6,7,8-Tetrahydromonapterin
C21008  7,8-Dihydromonapterin
C21065  7,8-Dihydroxanthopterin
C21094  7,8-Dihydromonapterin 3'-triphosphate
C21107  4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
C21310  (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C21485  Cytidylyl molybdenum cofactor
C21486  Thio-molybdenum cofactor
C21640  6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19675644
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Reference
PMID:16632608
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103
Reference
PMID:18092812
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g
Reference
PMID:12571226
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200
Reference
PMID:21867484
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
PMID:12893295
  Authors
Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  Title
Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  Journal
Arch Biochem Biophys 416:180-7 (2003)
DOI:10.1016/S0003-9861(03)00295-9
Reference
PMID:1902669
  Authors
Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  Title
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  Journal
Biochem Biophys Res Commun 175:738-44 (1991)
DOI:10.1016/0006-291X(91)91628-P
Related
pathway
dme00230  Purine metabolism
dme00400  Phenylalanine, tyrosine and tryptophan biosynthesis
dme00670  One carbon pool by folate
KO pathway
ko00790   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (40)   
   KEGG GENES (40)   
All databases (41)   

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