KEGG   Drosophila melanogaster (fruit fly): Dmel_CG10079
Entry
Dmel_CG10079      CDS       T00030                                 
Symbol
Egfr
Name
(RefSeq) epidermal growth factor receptor, isoform B
  KO
K04361  epidermal growth factor receptor [EC:2.7.10.1]
Organism
dme  Drosophila melanogaster (fruit fly)
Pathway
dme03272  Virion - Hepatitis viruses
dme04013  MAPK signaling pathway - fly
dme04068  FoxO signaling pathway
dme04144  Endocytosis
dme04214  Apoptosis - fly
dme04320  Dorso-ventral axis formation
Brite
KEGG Orthology (KO) [BR:dme00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03272 Virion - Hepatitis viruses
    Dmel_CG10079 (Egfr)
 09130 Environmental Information Processing
  09132 Signal transduction
   04013 MAPK signaling pathway - fly
    Dmel_CG10079 (Egfr)
   04068 FoxO signaling pathway
    Dmel_CG10079 (Egfr)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    Dmel_CG10079 (Egfr)
  09143 Cell growth and death
   04214 Apoptosis - fly
    Dmel_CG10079 (Egfr)
 09150 Organismal Systems
  09158 Development and regeneration
   04320 Dorso-ventral axis formation
    Dmel_CG10079 (Egfr)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:dme01001]
    Dmel_CG10079 (Egfr)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:dme04147]
    Dmel_CG10079 (Egfr)
Enzymes [BR:dme01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     Dmel_CG10079 (Egfr)
Protein kinases [BR:dme01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   Dmel_CG10079 (Egfr)
Exosome [BR:dme04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   Dmel_CG10079 (Egfr)
  Exosomal proteins of pancreatic cancer cells
   Dmel_CG10079 (Egfr)
  Exosomal proteins of bladder cancer cells
   Dmel_CG10079 (Egfr)
Cytokine receptors [BR:dme04050]
 Receptor tyrosine kinase
  RTK class I (EGF receptor family)
   Dmel_CG10079 (Egfr)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like Kinase-like TM_ErbB1
Other DBs
NCBI-GeneID: 37455
NCBI-ProteinID: NP_476759
FlyBase: FBgn0003731
UniProt: P04412
Structure
Position
2R
AA seq 1426 aa
MLLRRRNGPCPFPLLLLLLAHCICIWPASAARDRYARQNNRQRHQDIDRDRDRDRFLYRS
SSAQNRQRGGANFALGLGANGVTIPTSLEDKNKNEFVKGKICIGTKSRLSVPSNKEHHYR
NLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIR
GRTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVS
NGTDAYYNYDFTAPERECPKCHESCTHGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPR
ECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGA
TCVKECPGHLLRDNGACVRSCPQDKMDKGGECVPCNGPCPKTCPGVTVLHAGNIDSFRNC
TVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQF
RNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVS
NIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNG
TCIADCGYISNAYKFDNRTCKICHPECRTCNGAGADHCQECVHVRDGQHCVSECPKNKYN
DRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYV
HPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTD
EEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHV
NYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKK
ETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPE
GENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMP
LGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKIT
DFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRP
HENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARD
PGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGSEAIAEPDDYLQPKAAPGPSHRTD
CTDEIPKLNRYCKDPSNKNSSTGDDETDSSAREVGVGNLRLDLPVDEDDYLMPTCQPGPN
NNNNINNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNAQTLGVGESPIPTQTIGIPV
MGVPGTMEVKVPMPGSEPTSSDHEYYNDTQRELQPLHRNRNTETRV
NT seq 4281 nt   +upstreamnt  +downstreamnt
atgctgctgcgacggcgcaacggcccctgccccttccccctgctgctcctgctcctggcc
cactgcatttgcatttggcccgcgtcggcggcccgcgatcgctacgcccgccagaacaat
cgccagcgccatcaggatatagatcgcgatcgggatcgagatcgattcctataccgcagc
agttcggcccaaaatcgacagaggggcggggccaacttcgccctgggactgggagccaac
ggagtcaccattcccaccagtctggaggataagaacaagaacgagttcgtcaaggggaaa
atctgcatcggcactaaatctcggctctccgtgccctccaacaaggaacatcattaccgg
aacctcagagatcggtacacgaactgtacgtatgtggatggcaacctggagctgacctgg
ctgcccaacgagaatttggacctcagcttcctggacaacatacgggaggtcaccggctat
attctgatcagtcatgtggacgttaagaaagtggtatttcccaaactacaaatcattcgc
ggacgcacgctgttcagcttatccgtggaggaggagaagtatgccttgttcgtcacttat
tccaaaatgtacacgctggagattcccgatctacgcgatgtcttaaatggccaagtgggc
ttccacaacaactacaatctctgccacatgcgaacgatccagtggtcggagattgtatcc
aacggcacggatgcatactacaactacgactttactgctccggagcgcgagtgtcccaag
tgccacgagagctgcacgcacggatgttggggcgagggtcccaagaattgccagaagttc
agcaagctcacctgctcgccacagtgtgccggaggtcgttgctatggaccaaagccgcgg
gagtgttgtcacctcttctgcgccggaggatgcactggtcccacgcaaaaggattgcatc
gcctgcaagaacttcttcgacgagggcgtatgcaaggaggaatgcccgcccatgcgcaag
tacaatcccaccacctatgttcttgaaacgaatcctgagggaaagtatgcctatggtgcc
acctgcgtcaaggagtgtcccggtcatctgttgcgtgataatggcgcctgcgtgcgcagc
tgtccccaggacaagatggacaaggggggcgagtgtgtgccctgcaatggaccgtgcccc
aaaacctgcccgggcgttactgtcctgcatgccggcaacattgactcgttccggaattgt
acggtgatcgatggcaacattcgcattttggatcagaccttctcgggcttccaggatgtc
tatgccaactacacgatgggaccacgatacataccgctggatcccgagcgactggaggtg
ttctccacggtgaaggagatcaccgggtatctgaatatcgagggaacccacccgcagttc
cggaatctgtcgtacttccgcaatctggaaacaattcatggccgccagctgatggagagc
atgtttgccgctttggcgatcgttaagtcatccctgtacagcctggagatgcgcaatctg
aagcagattagttccggcagtgtggtcatccagcataatagagacctctgctacgtaagc
aatatccgttggccggccattcagaaggagcccgaacagaaggtgtgggtcaacgagaat
ctcagggcggatctatgcgagaaaaatggaaccatttgctcggatcagtgcaacgaggac
ggctgctggggagctggcacggatcagtgccttacctgcaagaacttcaatttcaatggc
acctgcatcgccgactgtggttatatatccaatgcctacaagtttgacaatagaacgtgc
aagatatgccatccagagtgccggacttgcaatggagctggagcagatcactgccaggag
tgcgtccatgtgagggacggtcagcactgtgtgtccgagtgcccgaagaacaagtacaac
gatcgtggtgtctgccgagagtgccacgccacctgcgatggatgcactgggcccaaggac
accatcggcattggagcgtgtacaacgtgcaatttggccattatcaacaatgacgccaca
gtaaaacgctgcctgctgaaggacgacaagtgccccgatgggtacttctgggagtatgtg
catccacaagagcagggatcgctaaagccattggccggcagagcagtttgccgaaagtgc
catcccctttgcgagctgtgcaccaactacggataccatgaacaggtgtgctccaagtgc
acccactacaagcgacgagagcagtgcgagaccgagtgtccggccgatcactacacggat
gaggagcagcgcgagtgcttccagtgccacccagaatgcaacggttgcactggtccgggt
gccgacgattgcaagtcttgtcgcaacttcaagttgttcgacgcgaatgagacgggtccc
tatgtgaactccacgatgttcaattgcacctcgaagtgtcccttggagatgcgacatgtg
aactatcagtacacggccattggaccctactgtgcagctagtccgccgaggagcagcaag
ataactgccaatctggatgtgaacatgatcttcattatcactggtgctgttctggtgccg
acgatctgcatcctctgcgtggtcacatacatttgtcggcaaaagcaaaaggccaagaaa
gaaacagtgaagatgaccatggctctgtccggctgtgaggattccgagccgctgcgtccc
tcgaacattggagccaatctatgcaagttgcgcattgtcaaggacgccgagttgcgcaag
ggcggagtcctcggaatgggagcctttggacgagtgtacaagggcgtttgggtgccggag
ggtgagaacgtcaagattccagtggccattaaggagctgctcaagtccacaggcgccgag
tcaagcgaagagttcctccgcgaagcctacatcatggcctctgtggagcacgttaatctg
ctgaagctcctggccgtctgcatgtcctcacaaatgatgctaatcacgcaactgatgccg
cttggctgcctgttggactatgtgcgaaataaccgggacaagatcggctctaaggctctg
ctcaactggagcacgcaaatcgccaagggcatgtcgtatctggaggagaagcgactggtc
cacagagacttggctgcccgcaatgtcctggtgcagactccctcgctggtgaagatcacc
gactttgggctggccaagttgctgagcagcgattccaatgagtacaaggctgctggcggc
aagatgcccatcaagtggttggcactggagtgcattcgcaatcgtgtattcaccagcaag
tccgatgtctgggcctttggtgtgacaatttgggaactgctgacctttggccagcgtcca
cacgagaacatccccgctaaggatattcccgatcttattgaagtcggtctgaagctggag
cagccggagatttgttcgctggacatttactgcacacttctctcgtgctggcacttggat
gccgccatgcgtccaaccttcaagcagctgactacggtctttgctgagttcgccagagat
ccgggtcgctatctggccattcccggggataagttcacccggctgccggcctacacgagt
caggatgagaaggatctcatccgaaaattggctcccaccaccgatgggtccgaagccatt
gcggaacccgatgactacctgcaacccaaggcagcacctggtcctagtcacagaaccgac
tgcacggatgagatacccaagctgaaccgctactgcaaggatcctagcaacaagaattcg
agtaccggagacgatgagacggattcgagtgcccgggaagtgggcgtgggtaatctgcgc
ctcgatctaccagtcgatgaggatgattacctgatgcccacatgccaaccggggcccaac
aacaacaacaacataaataatcccaatcaaaacaatatggcagctgtgggcgtggctgcc
ggctacatggatctcatcggagtgcccgttagtgtggacaatccggagtatctgctaaac
gcgcagacactgggtgttggggagtcgccgatacccacccagaccatcgggataccggtg
atgggagtcccgggcaccatggaggtcaaggtgccaatgccaggcagtgagccaacgagc
tccgatcacgagtactacaatgatacccaacgggagttgcagccactgcatcgaaaccgc
aacacggagacgagggtgtag

  All links  
Gene (82)   
   RefGene (78)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   FLYBASE (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
3D Structure (3)   
   PDB (3)   
Protein domain (7)   
   Pfam (7)   
All databases (98)   

Download RDF
DBGET integrated database retrieval system