KEGG   Drosophila melanogaster (fruit fly): Dmel_CG2259
Entry
Dmel_CG2259       CDS       T00030                                 
Symbol
Gclc
Name
(RefSeq) Glutamate-cysteine ligase catalytic subunit, isoform C
  KO
K11204  glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]
Organism
dme  Drosophila melanogaster (fruit fly)
Pathway
dme00270  Cysteine and methionine metabolism
dme00480  Glutathione metabolism
dme01100  Metabolic pathways
dme01240  Biosynthesis of cofactors
Module
dme_M00118  Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:dme00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    Dmel_CG2259 (Gclc)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    Dmel_CG2259 (Gclc)
Enzymes [BR:dme01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.2  glutamate---cysteine ligase
     Dmel_CG2259 (Gclc)
SSDB
Motif
Pfam: GCS GCS2 DNA_pol_B DUF2229 Cwf_Cwc_15
Other DBs
NCBI-GeneID: 53581
NCBI-ProteinID: NP_001285001
FlyBase: FBgn0040319
UniProt: Q9W3K5 A4V448
Position
X:complement(8102181..8116147)
AA seq 717 aa
MGLLSEGSPLSWEETKALADHVREHGVNQFINLYHRLKDRQGDILKWGDEVEYIIVKFDD
EQKVARVALRAQDLLAQLNEKELADPNGVKSLWRPEYGAYMIEGTPGKPFGGLMAHFNLV
EANMRYRREEVTELLAKDECVMSITNFPRLGAPNFTYPLAQPRPEDPLSSARSLYFPDEA
IFPGHPRFKTLTRNIRKRRGEKVSIKLKVFKDTKTKLPVEGAPPGEPDVVLLDAMGFGMG
CCCLQLTFQACNITEARRLYDQLAPLCPIMLALTAASPIYRGYLTESDCRWNVISSSVDC
RTEEERGLAPLDQQKFRIAKSRYDSIDSYLSPEGAKYNDVPLTYDEKVYQRLVEGGIDHL
LAQHVAHLFIRDTVSLFSEKVHQNDNEDTDHFENIQSTNWQTMRFKPPPPNSSIGWRVEF
RPCEAQISDFENAAIVCFVVLLTRVILSYQLNFLTPISKVDENMQTAQKRDACRKEKFWF
RKSSKTTEQRAAKAQAQAQAQAKAQAQTNGKATLNGNGLANGNGNGSENSDQEEQQPLTN
GSAKMNGHGSGTTNGTNGSSNGSSNGTDSDHTDTDDEENELFQLLSINEIFNGKPNVFPG
LVPLIRSYLQSMEVDTDTHCTIEQYLRFIQKRAAGELITTATWMREQVLSHPDYKQDSVV
SERINYDLLKRIQGIQEGKQVEPALLGQDYHSKTKTKDFIPPALQKQLAKNGCCEEK
NT seq 2154 nt   +upstreamnt  +downstreamnt
atgggtctactgagcgagggcagtccactctcctgggaggagaccaaggcgctggctgat
catgtgcgtgagcatggcgtcaatcagttcatcaacttgtaccacagactcaaggatcgc
cagggtgacatattgaaatggggcgacgaggtggagtacattattgtcaagttcgacgat
gaacagaaggtggcacgtgtggcgctgcgcgcccaggatctgctggcacagctcaatgag
aaggaactggccgatcccaatggtgtcaagtcgctgtggcgtccggaatacggagcctac
atgattgagggcacaccgggcaaaccctttggcggtctgatggcacacttcaatctggtt
gaggccaatatgcgctatcgtcgcgaagaggtcaccgagctgctggccaaggacgagtgc
gttatgtccattacgaatttcccacgactcggcgcaccaaatttcacttatccgcttgcc
cagccgcgtcccgaggatcctctcagttcagcccgctcgctctacttcccggatgaggcc
atctttccgggtcacccgcgtttcaagacactcacgcgtaacattcgcaagcgacgcggc
gagaaggtgtccatcaagctaaaagttttcaaggacacaaagacgaagctaccggtggag
ggtgctccgcctggcgaaccggatgtggtgctcctggacgccatgggcttcggcatgggc
tgctgttgcttgcagctcaccttccaggcctgtaacattacggaggcgcgtcgcctctac
gatcagctggctcccctctgtccgatcatgttggctctgacggccgcttcgcccatttac
aggggctatctaaccgaatcggattgtcgatggaatgtgattagctcctcggtggattgc
cgcacggaagaggaacgcggactggcgccgctggatcagcaaaagttcaggatagccaag
tcgcgatacgattcgattgactcgtatttgtcgcccgagggagccaaatataacgatgta
ccgctcacatacgatgagaaggtctatcagcgtctggtggagggcggtatcgatcatctg
ttggcccagcatgttgcccatttgtttatacgcgacaccgtgtcgctgttcagcgagaag
gtgcatcaaaacgacaacgaggatacggatcatttcgagaacattcagtccaccaattgg
cagaccatgcgcttcaagccgccgccaccgaacagctccattggctggcgtgtcgagttt
cgaccttgcgaggcgcagatcagtgatttcgagaatgcggccatcgtgtgctttgtggtg
ctgctcacccgtgtgattctctcctaccagctgaacttcctaacgccgatcagcaaggtg
gacgagaacatgcagacggcccagaagcgagatgcttgtcgcaaggagaagttttggttc
cgcaaatcctcgaagaccaccgagcagagggcggccaaggcgcaggcacaagctcaagcg
caagctaaagcccaggcccagacgaatggcaaggccactttgaatggcaatggactggcg
aatggaaatgggaatggcagcgagaacagtgaccaggaagagcagcagcctctgaccaac
ggttcggccaagatgaatggccacggaagtggcaccactaacggcactaatggctcctcc
aatggatcatcgaatggcaccgatagcgatcacaccgacaccgatgacgaggagaatgag
ctgttccagctgctgtccatcaatgagatcttcaatggaaagcccaacgtttttccgggt
ctggtgccattgatccgcagctatttgcagtccatggaggtggacaccgatacgcattgc
accattgaacagtatcttcgctttatccagaagcgtgccgccggcgagctaatcaccacg
gccacctggatgcgcgaacaggtgcttagccacccggattacaagcaggattccgtggtg
agcgagcgcatcaactacgatttgctgaagcgcatccaaggcatccaggagggcaagcag
gtggagccagcgctgctcggacaagactatcattccaagacgaagacgaaagacttcatt
ccgccggccttgcagaagcagttagccaagaacggctgctgcgaggagaaatga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (42)   
   KEGG ORTHOLOGY (1)   
   RefGene (37)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   FLYBASE (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (4)   
   RefSeq(nuc) (4)   
Protein domain (5)   
   Pfam (5)   
All databases (77)   

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