| Entry |
|
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| Name |
Rifampin (USP);
Rifampicin (JP18/INN);
Rifadin (TN);
Rimactane (TN) |
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| Abbr |
RIF |
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| Product |
|
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| Generic |
RIFAMPIN (A-S Medication Solutions), RIFAMPIN (A-S Medication Solutions), RIFAMPIN (American Health Packaging), RIFAMPIN (Asclemed USA), RIFAMPIN (Bryant Ranch Prepack), RIFAMPIN (Chartwell RX), RIFAMPIN (EPIC PHARMA), RIFAMPIN (Eon Labs), RIFAMPIN (Fresenius Kabi USA), RIFAMPIN (Hikma Pharmaceuticals USA), RIFAMPIN (Lupin Pharmaceuticals), RIFAMPIN (Mylan Institutional LLC), RIFAMPIN (PURACAP LABORATORIES LLC DBA BLU PHARMACEUTICALS), RIFAMPIN (REMEDYREPACK), RIFAMPIN (RPK Pharmaceuticals) |
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| Formula |
C43H58N4O12
|
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| Exact mass |
822.4051
|
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| Mol weight |
822.9402
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Antibacterial
DG01966 Antitubercular
DG01598 Rifamycin antibiotic
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG03195 UGT inducer
Transporter inhibitor
DG02865 SLCO1B1 inhibitor
DG02907 SLCO1B3 inhibitor
Transporter inducer
DG01893 ABCB1 inducer
|
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| Remark |
| Therapeutic category: | 6164 |
| Product (DG00639): | D00211<JP/US> |
|
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| Efficacy |
Antibacterial, RNA polymerase inhibitor |
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| Disease |
|
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| Comment |
Semisynthetic analog of Rifamycin [DR: D02549]
|
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| Target |
|
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| Pathway |
|
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| Interaction |
CYP induction: CYP3A4 [HSA: 1576]
Transporter induction: ABCB1 [HSA: 5243]
Transporter inhibition: SLCO1B1 [HSA: 10599], SLCO1B3 [HSA: 28234]
Enzyme induction: UGT [KO: K00699]
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J04 ANTIMYCOBACTERIALS
J04A DRUGS FOR TREATMENT OF TUBERCULOSIS
J04AB Antibiotics
J04AB02 Rifampicin
D00211 Rifampin (USP) <JP/US>
USP drug classification [BR:br08302]
Antimycobacterials
Antituberculars
Rifampin
D00211 Rifampin (USP)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
61 Antibiotics
616 Acting mainly on acid-fast bacteria
6164 Rifampicins
D00211 Rifampin (USP); Rifampicin (JP18/INN)
Drug groups [BR:br08330]
Antibacterial
DG01966 Antitubercular
DG01598 Rifamycin antibiotic
DG00639 Rifampicin
D00211 Rifampin
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00639 Rifampicin
D00211 Rifampin
DG03195 UGT inducer
DG00639 Rifampicin
D00211 Rifampin
Transporter inhibitor
DG02865 SLCO1B1 inhibitor
DG00639 Rifampicin
D00211 Rifampin
DG02907 SLCO1B3 inhibitor
DG00639 Rifampicin
D00211 Rifampin
Transporter inducer
DG01893 ABCB1 inducer
DG00639 Rifampicin
D00211 Rifampin
Antimicrobials [BR:br08307]
Antibacterials
Nucleic acid synthesis inhibitor
Rifamycin
D00211 Rifampin (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00211 Rifampicin
D00211 Rifampicin capsules
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00211
Drug transporters
D00211
Drug groups [BR:br08330]
Antibacterial
DG01966 Antitubercular
DG01598 Rifamycin antibiotic
DG00639 Rifampicin
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00639 Rifampicin
DG03195 UGT inducer
DG00639 Rifampicin
Transporter inhibitor
DG02865 SLCO1B1 inhibitor
DG00639 Rifampicin
DG02907 SLCO1B3 inhibitor
DG00639 Rifampicin
Transporter inducer
DG01893 ABCB1 inducer
DG00639 Rifampicin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Nucleic acid synthesis inhibitor
Rifamycin
DG00639 Rifampicin
|
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| Other DBs |
|
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| KCF data |
ATOM 59
1 C1c C 22.1075 -19.5906
2 C1c C 22.1075 -21.0113
3 O1a O 24.4754 -20.9437
4 C1c C 24.4754 -19.5906
5 C1c C 23.2576 -18.9141
6 C2b C 26.7756 -19.5906
7 C1c C 25.6255 -18.9141
8 C5a C 27.9933 -21.6879
9 C2c C 29.1435 -21.0113
10 C2b C 29.1435 -19.5906
11 C2b C 27.9933 -18.9141
12 C1a C 25.6255 -17.5610
13 C1a C 23.2576 -17.5610
14 O1a O 20.9574 -18.9141
15 C1a C 30.2936 -21.6879
16 O5a O 26.8432 -21.0113
17 N1b N 27.9933 -23.3116
18 C1c C 20.9574 -21.6879
19 O7a O 19.8073 -21.0113
20 C1c C 20.9574 -23.3116
21 C8y C 26.8432 -23.9881
22 C8y C 26.8432 -25.3412
23 C8y C 25.6255 -23.3116
24 C8y C 24.4754 -23.9881
25 C8y C 24.4754 -25.3412
26 C8y C 25.6255 -26.0177
27 C8y C 23.3252 -23.3116
28 C8y C 22.1075 -23.9881
29 C8y C 22.1075 -25.3412
30 C8y C 23.3252 -26.0177
31 O1a O 25.6255 -21.9585
32 O1a O 23.3252 -21.9585
33 C1a C 20.9574 -19.9289
34 C7a C 18.5895 -20.3348
35 C1a C 17.4394 -21.0113
36 O6a O 18.5895 -18.9817
37 C1c C 19.8073 -23.9881
38 O2a O 18.6571 -23.3116
39 C2b C 19.8073 -25.3412
40 C1a C 19.8073 -22.3644
41 C1a C 17.5070 -23.9881
42 C2b C 18.6571 -26.0177
43 O2a O 18.6571 -27.3708
44 O2x O 20.9574 -26.0177
45 C1z C 20.9574 -27.3708
46 C5x C 23.3252 -27.3708
47 C1a C 20.9574 -28.7238
48 C1a C 22.1075 -22.6350
49 O1a O 25.6255 -27.3708
50 O5x O 24.4077 -28.0473
51 C2b C 28.0244 -26.0366
52 N2b N 29.2227 -25.3581
53 N1y N 30.3970 -26.0493
54 C1x C 30.3852 -27.4400
55 C1x C 31.5917 -28.1502
56 N1y N 32.8100 -27.4606
57 C1x C 32.8218 -26.0699
58 C1x C 31.6154 -25.3596
59 C1a C 34.0220 -28.1742
BOND 63
1 1 2 1
2 4 3 1 #Down
3 4 5 1
4 1 5 1
5 6 7 1
6 4 7 1
7 8 9 1
8 9 10 2
9 10 11 1
10 6 11 2
11 7 12 1 #Up
12 5 13 1 #Down
13 1 14 1 #Down
14 9 15 1
15 8 16 2
16 8 17 1
17 2 18 1
18 18 19 1 #Up
19 18 20 1
20 17 21 1
21 21 22 1
22 21 23 2
23 23 24 1
24 24 25 1
25 25 26 1
26 24 27 2
27 27 28 1
28 28 29 2
29 29 30 1
30 25 30 2
31 23 31 1
32 27 32 1
33 2 33 1 #Up
34 19 34 1
35 34 35 1
36 34 36 2
37 26 22 2
38 20 37 1
39 37 38 1 #Down
40 37 39 1
41 20 40 1 #Down
42 38 41 1
43 39 42 2
44 42 43 1
45 29 44 1
46 44 45 1
47 43 45 1
48 30 46 1
49 45 46 1
50 45 47 1 #Down
51 28 48 1
52 26 49 1
53 50 46 2
54 22 51 1
55 51 52 2
56 52 53 1
57 53 54 1
58 54 55 1
59 55 56 1
60 56 57 1
61 57 58 1
62 53 58 1
63 56 59 1
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