 | | DRUG: Bumetanide | |
| Entry |
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| Name |
Bumetanide (JP18/USP/INN);
Bumex (TN) |
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| Product |
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| Generic |
BUMETANIDE (A-S Medication Solutions), BUMETANIDE (A-S Medication Solutions), BUMETANIDE (A-S Medication Solutions), BUMETANIDE (A-S Medication Solutions), BUMETANIDE (A-S Medication Solutions), BUMETANIDE (A-S Medication Solutions), BUMETANIDE (A-S Medication Solutions), BUMETANIDE (A-S Medication Solutions), BUMETANIDE (A-S Medication Solutions), BUMETANIDE (A-S Medication Solutions), BUMETANIDE (American Health Packaging), BUMETANIDE (Amneal Pharmaceuticals NY LLC), BUMETANIDE (Aphena Pharma Solutions - Tennessee), BUMETANIDE (Aphena Pharma Solutions - Tennessee), BUMETANIDE (Athenex Pharmaceutical Division), BUMETANIDE (AvPAK), BUMETANIDE (Bryant Ranch Prepack), BUMETANIDE (Bryant Ranch Prepack), BUMETANIDE (Bryant Ranch Prepack), BUMETANIDE (Bryant Ranch Prepack), BUMETANIDE (Bryant Ranch Prepack), BUMETANIDE (Cardinal Health 107), BUMETANIDE (Cardinal Health 107), BUMETANIDE (Cardinal Health 107), BUMETANIDE (Civica), BUMETANIDE (Edenbridge Pharmaceuticals LLC.), BUMETANIDE (Fresenius Kabi USA), BUMETANIDE (GLENMARK PHARMACEUTICALS), BUMETANIDE (Gland Pharma Limited), BUMETANIDE (HF Acquisition Co LLC), BUMETANIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), BUMETANIDE (Hikma Pharmaceuticals USA), BUMETANIDE (Hikma Pharmaceuticals USA), BUMETANIDE (Major Pharmaceuticals), BUMETANIDE (NCS HealthCare of KY), BUMETANIDE (Novadoz Pharmaceuticals LLC), BUMETANIDE (Proficient Rx LP), BUMETANIDE (Rising Pharma Holdings), BUMETANIDE (Sagent Pharmaceuticals), BUMETANIDE (Sandoz), BUMETANIDE (Taro Pharmaceuticals U.S.A.), BUMETANIDE (Upsher-Smith Laboratories), BUMETANIDE (Zydus Lifesciences Limited), BUMETANIDE (Zydus Pharmaceuticals (USA)) |
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| Formula |
C17H20N2O5S
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| Exact mass |
364.1093
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| Mol weight |
364.42
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01690 Sulfonamide diuretic
DG01746 Piretanide type diuretic
DG01748 Loop diuretic
DG01746 Piretanide type diuretic
Transporter substrate
DG02860 SLC22A8 substrate
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| Remark |
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| Efficacy |
Diuretic, Na-K-Cl cotransporter inhibitor |
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| Disease |
Nephrotic syndrome [DS: H01657] |
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| Comment |
Loop diuretic
Sulfonamide derivative
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| Target |
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| Metabolism |
Transporter: SLC22A8 [HSA: 9376]
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| Interaction |
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| Structure map |
| map07017 | Sulfonamide derivatives - diuretics |
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| Other map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C03 DIURETICS
C03C HIGH-CEILING DIURETICS
C03CA Sulfonamides, plain
C03CA02 Bumetanide
D00247 Bumetanide (JP18/USP/INN) <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Diuretics, Loop
Bumetanide
D00247 Bumetanide (JP18/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01690 Sulfonamide diuretic
DG01746 Piretanide type diuretic
D00247 Bumetanide
DG01748 Loop diuretic
DG01746 Piretanide type diuretic
D00247 Bumetanide
Transporter substrate
DG02860 SLC22A8 substrate
D00247 Bumetanide
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC12
SLC12A1 (NKCC2)
D00247 Bumetanide (JP18/USP/INN) <US>
SLC12A2 (NKCC1)
D00247 Bumetanide (JP18/USP/INN) <US>
SLC12A4
D00247 Bumetanide (JP18/USP/INN) <US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00247 Bumetanide
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D00247
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| Other DBs |
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| KCF data |
ATOM 25
1 C8y C 20.0084 -14.7933
2 C8y C 18.8179 -15.4820
3 C8y C 20.0027 -13.4217
4 O2a O 21.1932 -15.4761
5 C8x C 17.6215 -14.7933
6 N1b N 18.8237 -16.8592
7 C8x C 18.8120 -12.7330
8 S4a S 21.1932 -12.7330
9 C8y C 22.6347 -16.1998
10 C8y C 17.6215 -13.4217
11 C1b C 17.6272 -17.5479
12 N1a N 22.5648 -11.8226
13 O3c O 21.9169 -13.9061
14 O3c O 20.4812 -11.4083
15 C8x C 22.6347 -17.5772
16 C8x C 23.8311 -15.5052
17 C6a C 16.4367 -12.7273
18 C1b C 16.4367 -16.8651
19 C8x C 23.8311 -18.2658
20 C8x C 25.0159 -16.1998
21 O6a O 15.2403 -13.4217
22 O6a O 16.4367 -11.3557
23 C1b C 15.2460 -17.5479
24 C8x C 25.0159 -17.5772
25 C1a C 14.0555 -16.8651
BOND 26
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 1
7 3 8 1
8 4 9 1
9 5 10 1
10 6 11 1
11 8 12 1
12 8 13 2
13 8 14 2
14 9 15 2
15 9 16 1
16 10 17 1
17 11 18 1
18 15 19 1
19 16 20 2
20 17 21 1
21 17 22 2
22 18 23 1
23 19 24 2
24 23 25 1
25 7 10 2
26 20 24 1
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