KEGG   DRUG: CaptoprilHelp
Entry
D00251                      Drug                                   

Name
Captopril (JP17/USP/INN);
Apopril (TN);
Capoten (TN)
Product
  Generic
CAPTOPRIL (Aidarex Pharmaceuticals LLC), CAPTOPRIL (American Health Packaging), CAPTOPRIL (Apotex Corp.), CAPTOPRIL (Avera McKennan Hospital), CAPTOPRIL (Avera McKennan Hospital), CAPTOPRIL (Blenheim Pharmacal), CAPTOPRIL (Bryant Ranch Prepack), CAPTOPRIL (Bryant Ranch Prepack), CAPTOPRIL (Bryant Ranch Prepack), CAPTOPRIL (Cardinal Health), CAPTOPRIL (Carilion Materials Management), CAPTOPRIL (DOH CENTRAL PHARMACY), CAPTOPRIL (GLENVIEW PHARMA), CAPTOPRIL (Legacy Pharmaceutical Packaging), CAPTOPRIL (Major Pharmaceuticals), CAPTOPRIL (Mylan Institutional), CAPTOPRIL (Mylan Pharmaceuticals), CAPTOPRIL (NCS HealthCare of KY), CAPTOPRIL (NuCare Pharmaceuticals), CAPTOPRIL (PD-Rx Pharmaceuticals), CAPTOPRIL (PD-Rx Pharmaceuticals), CAPTOPRIL (Physicians Total Care), CAPTOPRIL (Preferred Pharmaceuticals), CAPTOPRIL (Preferred Pharmaceuticals), CAPTOPRIL (REMEDYREPACK), CAPTOPRIL (REMEDYREPACK), CAPTOPRIL (Rebel Distributors Corp), CAPTOPRIL (RedPharm Drug), CAPTOPRIL (RedPharm Drug), CAPTOPRIL (SANDOZ), CAPTOPRIL (State of Florida DOH Central Pharmacy), CAPTOPRIL (Unit Dose Services), CAPTOPRIL (Unit Dose Services), CAPTOPRIL (Unit Dose Services), CAPTOPRIL (West-Ward Pharmaceuticals Corp), CAPTOPRIL (Windlas Healthcare (P)), CAPTOPRIL (Wockhardt Limited), CAPTOPRIL (Wockhardt USA LLC.), CAPTOPRIL (Aidarex Pharmaceuticals LLC), CAPTOPRIL (Rebel Distributors Corp)
Formula
C9H15NO3S
Exact mass
217.0773
Mol weight
217.2853
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01501  Angiotensin-converting enzyme inhibitor
 DG01925  Renin-angiotensin system inhibitor
  DG01501  Angiotensin-converting enzyme inhibitor
Remark
Same as: C06867
Therapeutic category: 2144
ATC code: C09AA01
Product: D00251<JP/US>
Product (mixture): D10276<US>
Efficacy
Antihypertensive, Angiotensin-converting enzyme inhibitor
  Disease
Hypertension [DS:H01633]
Diabetic Nephropathy [DS:H01456]
Target
ACE (CD143) [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system
Metabolism
Transporter: SLC15A1 [HSA:6564], SLC15A2 [HSA:6565], SLC22A6 [HSA:9356]
Interaction
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
map07217  Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA01 Captopril
      D00251  Captopril (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin-converting Enzyme (ACE) Inhibitors
   Captopril
    D00251  Captopril (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2144  Angiotensin converting enzyme inhibitors
     D00251  Captopril (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Peptidyl-dipeptidases
    ACE (CD143)
     D00251  Captopril (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00251  Captopril
Drug classes of therapeutic agents [br08360.html]
 Cardiovascular agents
  D00251
Prodrugs [br08324.html]
 D00251
BRITE hierarchy
Other DBs
CAS: 62571-86-2
PubChem: 7847317
ChEBI: 3380
ChEMBL: CHEMBL1560 CHEMBL162360
DrugBank: DB01197
PDB-CCD: X8Z[PDBj]
LigandBox: D00251
NIKKAJI: J3.203D
KCF data Show

ATOM        14
            1   C1x C    30.3001  -29.3105
            2   C1x C    30.7108  -30.6489
            3   C1x C    32.1107  -30.6718
            4   C1y C    32.5650  -29.3476
            5   N1y N    31.4460  -28.5062
            6   C5a C    31.4460  -27.1062
            7   O5a O    32.6533  -26.4091
            8   C1c C    30.2145  -26.3954
            9   C1b C    29.0237  -27.0832
            10  S1a S    27.8339  -26.3964
            11  C6a C    33.8944  -28.9394
            12  O6a O    35.2472  -29.5220
            13  O6a O    33.8637  -27.5503
            14  C1a C    30.2142  -24.9902
BOND        14
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     5   6 1
            7     6   7 2
            8     6   8 1
            9     8   9 1
            10    9  10 1
            11    4  11 1 #Down
            12   11  12 1
            13   11  13 2
            14    8  14 1 #Up

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