KEGG   DRUG: ClotrimazoleHelp
Entry
D00282                      Drug                                   

Name
Clotrimazole (JP17/USP/INN);
Lotrimin (TN);
Mycelex (TN)
Product
  Generic
Formula
C22H17ClN2
Exact mass
344.108
Mol weight
344.8368
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antifungal
 DG01883  Imidazole antifungal
Remark
Same as: C06922
Therapeutic category: 2529 2655 6290
ATC code: A01AB18 D01AC01 G01AF02
Product: D00282<JP/US>
Product (mixture): D10300<US>
Efficacy
Antifungal, Ergosterol biosynthesis inhibitor
  Disease
Candidiasis [DS:H00363]
Comment
Imidazole derivative
Target
sterol 14alpha-demethylase [KO:K05917]
  Pathway
ko00100  Steroid biosynthesis
Interaction
Drug interaction
Structure map
map07026  Antifungal agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB18 Clotrimazole
      D00282  Clotrimazole (JP17/USP/INN) <JP/US>
 D DERMATOLOGICALS
  D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
   D01A ANTIFUNGALS FOR TOPICAL USE
    D01AC Imidazole and triazole derivatives
     D01AC01 Clotrimazole
      D00282  Clotrimazole (JP17/USP/INN) <JP/US>
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AF Imidazole derivatives
     G01AF02 Clotrimazole
      D00282  Clotrimazole (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antifungals
  Clotrimazole
   D00282  Clotrimazole (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   252  Genital organ agents
    2529  Others
     D00282  Clotrimazole (JP17/USP/INN)
  26  Epidermides
   265  Antiparasitic dermatosis agents
    2655  Imidazoles
     D00282  Clotrimazole (JP17/USP/INN)
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   629  Miscellaneous
    6290  Miscellaneous
     D00282  Clotrimazole (JP17/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Drugs for women
  51 Other drugs for women
   D00282  Clotrimazole (JP17/USP/INN)
 Agents for integumentary system
  58 Ringworm drugs
   D00282  Clotrimazole (JP17/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Clotrimazole
    D00282  Clotrimazole (JP17/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Clotrimazole
    D00282  Clotrimazole (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00282  Clotrimazole
Antiinfectives [br08350.html]
 Antifungals
  D00282
Rx-to-OTC switch list in the USA [br08315.html]
 D00282
Rx-to-OTC switch list in Japan [br08314.html]
 D00282
BRITE hierarchy
Other DBs
CAS: 23593-75-1
PubChem: 7847348
ChEBI: 3764
ChEMBL: CHEMBL104
DrugBank: DB00257
PDB-CCD: CL6[PDBj]
LigandBox: D00282
NIKKAJI: J3.156I
KCF data Show

ATOM        25
            1   C8x C    11.7600  -18.0600
            2   C8x C    11.7600  -19.4600
            3   C8x C    12.9724  -20.1600
            4   C8x C    14.1849  -19.4600
            5   C8x C    14.1849  -18.0600
            6   C8y C    12.9724  -17.3600
            7   C1d C    12.9724  -15.9600
            8   C8y C    12.9724  -14.5600
            9   C8y C    11.3400  -15.9600
            10  N4y N    14.5600  -15.9600
            11  C8y C    10.6400  -14.7476
            12  C8x C     9.2400  -14.7476
            13  C8x C     8.5400  -15.9600
            14  C8x C     9.2400  -17.1724
            15  C8x C    10.6400  -17.1724
            16  C8x C    14.1679  -13.8696
            17  C8x C    14.1678  -12.4696
            18  C8x C    12.9553  -11.7697
            19  C8x C    11.7598  -12.4601
            20  C8x C    11.7599  -13.8601
            21  C8x C    15.3829  -17.0926
            22  N5x N    16.7144  -16.6600
            23  C8x C    16.7144  -15.2600
            24  C8x C    15.3829  -14.8274
            25  X   Cl   10.6400  -13.3476
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     7   9 1
            10    7  10 1
            11    9  11 2
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16    9  15 1
            17    8  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22    8  20 1
            23   10  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   10  24 1
            28   11  25 1

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